Výsledky vyhledávání - "Marina Gálvez"

Akademický článek

In utero gene expression in the Slc39a8(neo/neo) knockdown mouse

Autor: Jing Chen, Marina Gálvez-Peralta, Xiang Zhang, Jingyuan Deng, Zijuan Liu, Daniel W. Nebert

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)

Abstract Slc39a8 encodes ZIP8, a divalent cation/bicarbonate symporter expressed in pluripotent mouse embryonic stem cells, and therefore ubiquitous in adult tissues; ZIP8 influxes Zn2+, Mn2+ and Fe2+. Slc39a8(neo/neo) knockdown mice exhibit 10–15%

Externí odkaz: https://doaj.org/article/32e704fac5234eef94815e00e2b0392f

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Akademický článek

ZIP8 Regulates Host Defense through Zinc-Mediated Inhibition of NF-κB

Autor: Ming-Jie Liu, Shengying Bao, Marina Gálvez-Peralta, Charlie J. Pyle, Andrew C. Rudawsky, Ryan E. Pavlovicz, David W. Killilea, Chenglong Li, Daniel W. Nebert, Mark D. Wewers, Daren L. Knoell

Publikováno v: Cell Reports, Vol 3, Iss 2, Pp 386-400 (2013)

Activation of the transcription factor NF-κB is essential for innate immune function and requires strict regulation. The micronutrient zinc modulates proper host defense, and zinc deficiency is associated with elevated inflammation and worse outcome

Externí odkaz: https://doaj.org/article/a203dfe7feba42c6998b37d6399fcbd5

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Akademický článek

ZIP8 zinc transporter: indispensable role for both multiple-organ organogenesis and hematopoiesis in utero.

Autor: Marina Gálvez-Peralta, Lei He, Lucia F Jorge-Nebert, Bin Wang, Marian L Miller, Bryan L Eppert, Scott Afton, Daniel W Nebert

Publikováno v: PLoS ONE, Vol 7, Iss 5, p e36055 (2012)

Previously this laboratory characterized Slc39a8-encoded ZIP8 as a Zn(2+)/(HCO(3)(-))(2) symporter; yet, the overall physiological importance of ZIP8 at the whole-organism level remains unclear. Herein we describe the phenotype of the hypomorphic Slc

Externí odkaz: https://doaj.org/article/334ad18e679e416c80dd67622b899a9b

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