Regulation of mycobacterial infection by macrophage Gch1 and tetrahydrobiopterin

Autor: Eileen McNeill, Elena Stylianou, Mark J. Crabtree, Rachel Harrington-Kandt, Anna-Lena Kolb, Marina Diotallevi, Ashley B. Hale, Paulo Bettencourt, Rachel Tanner, Matthew K. O’Shea, Magali Matsumiya, Helen Lockstone, Julius Müller, Helen A. Fletcher, David R. Greaves, Helen McShane, Keith M. Channon

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)

Inducible nitric oxide (NO) synthase (iNOS) is essential in the response to mycobacterial infection, yet NOS signalling can occur through NO-dependent or NO-independent pathways. Here the authors show macrophage Gch1 and tetrahydrobiopterin mediate N

Externí odkaz: https://doaj.org/article/6b10bf22d1cf44e59fc4465f802a33e8

Glutathione Fine-Tunes the Innate Immune Response toward Antiviral Pathways in a Macrophage Cell Line Independently of Its Antioxidant Properties

Autor: Marina Diotallevi, Paola Checconi, Anna Teresa Palamara, Ignacio Celestino, Lucia Coppo, Arne Holmgren, Kahina Abbas, Fabienne Peyrot, Manuela Mengozzi, Pietro Ghezzi

Publikováno v: Frontiers in Immunology, Vol 8 (2017)

Glutathione (GSH), a major cellular antioxidant, is considered an inhibitor of the inflammatory response involving reactive oxygen species (ROS). However, evidence is largely based on experiments with exogenously added antioxidants/reducing agents or

Externí odkaz: https://doaj.org/article/ddec7bfa630a4698a3735d9ddc80995b

Hepatic miR-144 drives fumarase activity preventing NRF2 activation during obesity

Autor: Valerio Azzimato, Ping Chen, Emelie Barreby, Cecilia Morgantini, Laura Levi, Ana Vankova, Jennifer Jager, André Sulen, Marina Diotallevi, Joanne X. Shen, Ewa Ellis, Mikael Ryden, Erik Naslund, Anders Thorell, Volker Lauschke, Keith M. Channon, Mark J. Crabtree, Arvand Haschemi, Siobhan M. Craige, Mattia Mori, Francesco Spallotta, Myriam Aouadi

Publikováno v: Journal of Hepatology. 77:S665-S666

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::499e918d6e735d01f2ad230cb3337307
https://doi.org/10.1016/s0168-8278(22)01649-x

Hepatic miR-144 Drives Fumarase Activity Preventing NRF2 Activation During Obesity

Autor: Mikael Rydén, Mattia Mori, Francesco Spallotta, Joanne X. Shen, Marina Diotallevi, André Sulen, Valerio Azzimato, Ping Chen, Jennifer Jager, Emelie Barreby, Laura Levi, Anders Thorell, Keith M. Channon, Erik Näslund, Ana Vankova, Arvand Haschemi, Myriam Aouadi, Siobhan M. Craige, Volker M. Lauschke, Cecilia Morgantini, Anne Miller, Mark J. Crabtree, Ewa Ellis

Publikováno v: Gastroenterology
Gastroenterology (Online) 161 (2021): 1982–1997.e11. doi:10.1053/j.gastro.2021.08.030
info:cnr-pdr/source/autori:Azzimato V.; Chen P.; Barreby E.; Morgantini C.; Levi L.; Vankova A.; Jager J.; Sulen A.; Diotallevi M.; Shen J.X.; Miller A.; Ellis E.; Ryden M.; Naslund E.; Thorell A.; Lauschke V.M.; Channon K.M.; Crabtree M.J.; Haschemi A.; Craige S.M.; Mori M.; Spallotta F.; Aouadi M./titolo:Hepatic miR-144 Drives Fumarase Activity Preventing NRF2 Activation During Obesity/doi:10.1053%2Fj.gastro.2021.08.030/rivista:Gastroenterology (Online)/anno:2021/pagina_da:1982/pagina_a:1997.e11/intervallo_pagine:1982–1997.e11/volume:161
Ping Chen

Background and Aims Oxidative stress plays a key role in the development of metabolic complications associated with obesity, including insulin resistance and the most common chronic liver disease worldwide, nonalcoholic fatty liver disease. We have r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1def7899bb36d9d1dd99f5ad6e9d5dc8
https://doi.org/10.1053/j.gastro.2021.08.030