Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Marina D Kirkitadze"'
Publikováno v:
Journal of Molecular Biology. 312:1103-1119
Amyloid beta-protein (Abeta) assembly into toxic oligomeric and fibrillar structures is a seminal event in Alzheimer's disease, therefore blocking this process could have significant therapeutic benefit. A rigorous mechanistic understanding of Abeta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::682568f765c4a79847de88992893fb5f
https://doi.org/10.1006/jmbi.2001.4970
https://doi.org/10.1006/jmbi.2001.4970
Autor:
Marina D. Kirkitadze, Paul N. Barlow
Publikováno v:
Immunological Reviews. 180:146-161
In this review we summarise more than 10 years of biophysical exploration into the structural biology of the regulators of complement activation (RCA). The five human proteins responsible for regulation of the early events of complement are homologou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c36cfc1bf0aea56953cb2de9c8253258
https://doi.org/10.1034/j.1600-065x.2001.1800113.x
https://doi.org/10.1034/j.1600-065x.2001.1800113.x
Autor:
Colin E. Henderson, Nicholas C. Price, David T. F. Dryden, John Parkinson, Sharon M. Kelly, Paul N. Barlow, Nicholas P. Mullin, Marina D. Kirkitadze
Publikováno v:
Biochemical Journal. 344:167-175
The 28.6 kDa vaccinia virus complement control protein (VCP) is an inhibitor of the complement system and has therapeutic potential. It is composed of four domains or modules and is a homologue of complement receptor 1 (CR1) and other mammalian regul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2cba7f1ac82e81bac8b54901862c005a
https://doi.org/10.1042/bj3440167
https://doi.org/10.1042/bj3440167
Autor:
Paul N. Barlow, Brian O. Smith, David T. F. Dryden, Alan Cooper, M. Krych, Dušan Uhrín, Marina D. Kirkitadze, Richard E. Hauhart, X. Wang, John P. Atkinson
Publikováno v:
Biochemistry. 38:7019-7031
A segment of complement receptor type 1 (CR1) corresponding to modules 15-17 was overexpressed as a functionally active recombinant protein with N-glycosylation sites ablated by mutagenesis (referred to as CR1 approximately 15-17(-)). A protein consi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::802cdabe6fa00924c0df4141cf51ce9b
https://doi.org/10.1021/bi982453a
https://doi.org/10.1021/bi982453a
Autor:
Paul N. Barlow, Nicholas C. Price, Chris Boutell, Frazer J. Rixon, Sharon M. Kelly, David A. McClelland, Marina D. Kirkitadze
Publikováno v:
Journal of Virology. 72:10066-10072
Two proteins, VP19C (50,260 Da) and VP23 (34,268 Da), make up the triplexes which connect adjacent hexons and pentons in the herpes simplex virus type 1 capsid. VP23 was expressed in Escherichia coli and purified to homogeneity by Ni-agarose affinity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b95babc66ea999da0358a558d8cb3ac
https://doi.org/10.1128/jvi.72.12.10066-10072.1998
https://doi.org/10.1128/jvi.72.12.10066-10072.1998
Autor:
John P. Atkinson, David T. F. Dryden, Marina D. Kirkitadze, Paul N. Barlow, Kornelia Jumel, M. Krych, Stephen E. Harding
Publikováno v:
Analytical Ultracentrifugation V ISBN: 9783540661757
Complement receptor type 1 (CR1) is a member of a family of regulators of complement activation with therapeutic potential. A fragment of CR1 comprising modules 16 and 17 was overexpressed as a recombinant nonglycosylated protein in Pichia pastoris.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66b5be604b201afc127a850445a12352
https://doi.org/10.1007/3-540-48703-4_23
https://doi.org/10.1007/3-540-48703-4_23
Autor:
Marina D, Kirkitadze, Anna, Kowalska
Publikováno v:
Acta biochimica Polonica. 52(2)
The deposition of aggregated amyloid beta-protein (Abeta) in the human brain is a major lesion in Alzheimer' disease (AD). The process of Abeta fibril formation is associated with a cascade of neuropathogenic events that induces brain neurodegenerati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c58e0593f85841100f9ee5d34a49dae6
https://pubmed.ncbi.nlm.nih.gov/15933761
https://pubmed.ncbi.nlm.nih.gov/15933761
Autor:
Darrell D. Mousseau, Gregory De Crescenzo, Maureen D. O'Connor-McCourt, Sadayuki Inoue, David B. Teplow, Sarah Chapelsky, Joanne Magoon, Marina D. Kirkitadze
Publikováno v:
Mousseau, DD; Chapelsky, S; De Crescenzo, G; Kirkitadze, MD; Magoon, J; Inoue, S; et al.(2003). A direct interaction between transforming growth factor (TGF)-βs and amyloid-β protein affects fibrillogenesis in a TGF-β receptor-independent manner. Journal of Biological Chemistry, 278(40), 38715-38722. doi: 10.1074/jbc.M304080200. UCLA: Retrieved from: http://www.escholarship.org/uc/item/7222p6q7
Transforming growth factor-beta (TGF-beta) receptor-mediated signaling has been proposed to mediate both the beneficial and deleterious roles for this cytokine in amyloid-beta protein (Abeta) function. In order to assess receptor dependence of these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79b740bcf2cc3369b53636713089b954
https://nrc-publications.canada.ca/eng/view/object/?id=c54f3713-33e9-468c-aac2-84fe618d156e
https://nrc-publications.canada.ca/eng/view/object/?id=c54f3713-33e9-468c-aac2-84fe618d156e
Autor:
Aleksey Lomakin, Gal Bitan, Sabrina S. Vollers, Marina D. Kirkitadze, David B. Teplow, George B. Benedek
Publikováno v:
Marina, GB; Kirkitadze, D; Lomakin, A; Vollers, SS; Benedek, GB; & Teplow, DB. (2003). Amyloid β-protein (Aβ) assembly: Aβ40 and Aβ42 oligomerize through distinct pathways. Proceedings of the National Academy of Sciences of the United States of America, 100(1), 330-335. doi: 10.1073/pnas.222681699. UCLA: Retrieved from: http://www.escholarship.org/uc/item/7rm5f539
Amyloid β-protein (Aβ) is linked to neuronal injury and death in Alzheimer's disease (AD). Of particular relevance for elucidating the role of Aβ in AD is new evidence that oligomeric forms of Aβ are potent neurotoxins that play a major role in n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e547e494adf03e060d6ab3fe536765c
http://www.escholarship.org/uc/item/7rm5f539
http://www.escholarship.org/uc/item/7rm5f539
Autor:
Gal, Bitan, Marina D, Kirkitadze, Aleksey, Lomakin, Sabrina S, Vollers, George B, Benedek, David B, Teplow
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 100(1)
Amyloid beta-protein (Abeta) is linked to neuronal injury and death in Alzheimer's disease (AD). Of particular relevance for elucidating the role of Abeta in AD is new evidence that oligomeric forms of Abeta are potent neurotoxins that play a major r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::55ab683eb0c3cf352703c70d347ad230
https://pubmed.ncbi.nlm.nih.gov/12506200
https://pubmed.ncbi.nlm.nih.gov/12506200