Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Marina Cetkovic-Cvrlje"'
Publikováno v:
Journal of Immunotoxicology, Vol 14, Iss 1, Pp 160-168 (2017)
Type 1 diabetes (T1D) is a T-cell-mediated autoimmune disorder characterized by destruction of insulin-producing pancreatic β-cells. Whereas epidemiological data implicate environmental factors in the increasing incidence of T1D, their identity rema
Externí odkaz:
https://doaj.org/article/b1d49e82b8014830b9378419f97c631f
Publikováno v:
International Journal of Immunopathology and Pharmacology
Objective T cells orchestrate an inflammatory response that destroys pancreatic insulin-producing β cells during the development of autoimmune type 1 diabetes (T1D). Garcinia kola Heckel (GK) is a plant widely exploited in West African traditional m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2032cdc016ba549ebd0488d39e1f1b00
http://europepmc.org/articles/PMC8777369
http://europepmc.org/articles/PMC8777369
Autor:
Heiko L. Schoenfuss, Tia-Marie Scott, Marina Cetkovic-Cvrlje, Dana W. Kolpin, Kelsey E. Lesteberg, Daniel C. Rearick, Patrick J. Phillips, Edward T. Furlong
Publikováno v:
Environmental Toxicology and Chemistry. 35:953-965
Pharmaceuticals are present in low concentrations (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1d518815672206e39f716665b7d857c
https://doi.org/10.1002/etc.3147
https://doi.org/10.1002/etc.3147
Exposure to DDT metabolitep,p′-DDE increases autoimmune type 1 diabetes incidence in NOD mouse model
Publikováno v:
Journal of Immunotoxicology. 13:108-118
The incidence of autoimmune Type 1 diabetes (T1D) has been steadily rising in developed countries. Although the exact cause of T1D remains elusive, it is known that both genetics and environmental factors play a role in its immunopathogenesis. Wherea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79978534b8e5024bee9011009252f090
https://doi.org/10.3109/1547691x.2015.1017060
https://doi.org/10.3109/1547691x.2015.1017060
Publikováno v:
Journal of immunotoxicology. 13(6)
Type 1 diabetes (T1D) incidence has been steadily rising across the globe. Exposure to persistent organic pollutants (POP) has been implied as one potential cause of increased T1D occurrence. Since data regarding the role of POP polychlorinated biphe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c152a9fdcafbdc80decd571c1d24b8db
https://pubmed.ncbi.nlm.nih.gov/27602506
https://pubmed.ncbi.nlm.nih.gov/27602506
Publikováno v:
Arzneimittelforschung. 53:648-654
Janus kinase (JAK) 3-deficient mice were not able to reject allogeneic islet allografts. The JAK3 inhibitor 4-(4'-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline (CAS 202475-60-3, JANEX-1, WHI-P131) prevented the rejection of islet allografts in mice w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c300fc561dee155d5922739500694d48
https://doi.org/10.1055/s-0031-1299807
https://doi.org/10.1055/s-0031-1299807
Autor:
Marina Cetkovic-Cvrlje, Fatih M. Uckun
Publikováno v:
Clinical Immunology. 114:299-306
The MLDS (multiple low doses of streptozotocin) model of diabetes was induced in Stat4(-/-), Stat6(-/-), and double-deficient Stat4(-/-)/6(-/-) mice to examine the role of STAT4/STAT6 deficiency in development of autoimmune diabetes. Cytokine product
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edb143fb468baa3b11f98603134a815d
https://doi.org/10.1016/j.clim.2004.11.001
https://doi.org/10.1016/j.clim.2004.11.001
Autor:
Fatih M. Uckun, Marina Cetkovic-Cvrlje
Publikováno v:
British Journal of Haematology. 126:821-827
The purpose of the present study was to evaluate the effectiveness of targeting Bruton's tyrosine kinase (BTK) with a specific BTK inhibitor, alpha-cyano-beta-hydroxy-beta-methyl-N-(2,5-dibromophenyl)-propenamide (LFM-A13), for prevention of acute fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a33558614ec74ae5694a4a53ca44a6a
https://doi.org/10.1111/j.1365-2141.2004.05126.x
https://doi.org/10.1111/j.1365-2141.2004.05126.x
Autor:
Vijayakumar K. Ramiya, Margot Bridgett, Robert W. O'Rourke, Marina Cetkovic-Cvrlje, Steinunn Baekkeskov, Jeremy Lambert, Edward H. Leiter, Yuguang Shi, Sandya Narayanswami
Publikováno v:
Diabetes. 47:1848-1856
Although expressed at very low levels in islets of NOD mice, GAD65 is a candidate islet autoantigen. Two transgenic lines of NOD/Lt mice expressing high levels of human GAD65 from a rat insulin promoter were generated. Transgenes were integrated on p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0a244e86a3d194d7ba1d4a9cc10eea0
https://doi.org/10.2337/diabetes.47.12.1848
https://doi.org/10.2337/diabetes.47.12.1848
Publikováno v:
Cellularmolecular immunology. 9(4)
Regulatory T cells (Tregs) are critical for the peripheral maintenance of the autoreactive T cells in autoimmune disorders such as type 1 diabetes (T1D). Pharmacological inhibition of Janus tyrosine kinase 3 (JAK3) has been proposed as a basis for ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b676171eb12f9f054822f5b0b4b4974
https://pubmed.ncbi.nlm.nih.gov/22728763
https://pubmed.ncbi.nlm.nih.gov/22728763