Long non-coding RNA expression profile in cytogenetically normal acute myeloid leukemia identifies a distinct signature and a new biomarker in NPM1-mutated patients

Autor: Etienne De Clara, Morgane Gourvest, Hanjing Ma, François Vergez, Marie Tosolini, Sébastien Dejean, Cécile Demur, Eric Delabesse, Christian Recher, Christian Touriol, Maria Paola Martelli, Brunangelo Falini, Pierre Brousset, Marina Bousquet

Publikováno v: Haematologica, Vol 102, Iss 10 (2017)

Long non-coding RNAs are defined as transcripts larger than 200 nucleotides but without protein-coding potential. There is growing evidence of the important role of long non-coding RNAs in cancer initiation, development and progression. In this study

Externí odkaz: https://doaj.org/article/c990b321c1104d49a724b0cf5baef9b6

Supplementary Figures 1 - 6 from miR-150 Blocks MLL-AF9–Associated Leukemia through Oncogene Repression

Autor: Beiyan Zhou, Stephen Safe, Gang Wang, Piu Wong, Guangtao Ge, Stephanie Wang, Andrew T. Shie, Patali S. Cheruku, Wei Ying, Cong Meng, Guoqing Zhuang, Marina Bousquet

PDF file - 146K, Figure S1. Analysis of microRNA profiles in various MLL-associated leukemias. Figure S2. Analysis of MLL-AF9 expression cells transformed from bone marrow stem/progenitors. Figure S3. Phenotypic analysis of leukemia from mice transpl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6088b97e8b1b8fb44597e33bc8acd2c2
https://doi.org/10.1158/1541-7786.22509880

PAX5-ELN oncoprotein promotes multistep B-cell acute lymphoblastic leukemia in mice

Autor: Guillaume Chemin, Sylvie Hébrard, Chloé Oudinet, Ngoc Sa Nguyen Huu, Pierre Brousset, Stéphanie Lagarde, Laura Jamrog, Vincent Fregona, Cyril Broccardo, Bastien Gerby, Cathy Quelen, Eric Delabesse, Marina Bousquet, Stéphane J. C. Mancini, Naïs Prade, Nelly Rouquié, Charlotte Cresson, Marlène Pasquet, Lucie Coster, Ahmed Amine Khamlichi

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2018, 115 (41), pp.10357-10362. ⟨10.1073/pnas.1721678115⟩

International audience; PAX5 is a well-known haploinsufficient tumor suppressor gene in human B-cell precursor acute lymphoblastic leukemia (B-ALL) and is involved in various chromosomal translocations that fuse a part of PAX5 with other partners. Ho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0897d5cf8c5dd337cf3b8d30ccb25c7b
https://hal.archives-ouvertes.fr/hal-02351122

miR-150 Blocks MLL-AF9–Associated Leukemia through Oncogene Repression

Autor: Stephanie W. Wang, Stephen Safe, Piu Wong, Marina Bousquet, Guoqing Zhuang, Guangtao Ge, Wei Ying, Cong Meng, Gang Wang, Andrew T. Shie, Patali S. Cheruku, Beiyan Zhou

Publikováno v: Molecular Cancer Research. 11:912-922

The microRNA miR-150, a critical regulator of hematopoiesis, is downregulated in mixed-lineage leukemia (MLL). In this study, miR-150 acts as a potent leukemic tumor suppressor by blocking the oncogenic properties of leukemic cells. By using MLL-AF9�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa19ec70216cdb33776092208199dfa4
https://doi.org/10.1158/1541-7786.mcr-13-0002-t

RNA editing in acute myeloid leukaemia with normal karyotype

Autor: Yaelle Eloit, Pierre Brousset, Céline Noirot, Cathy Quelen, Marina Bousquet

Publikováno v: British Journal of Haematology
British Journal of Haematology, Wiley, 2016, 173 (5), pp.788-790. ⟨10.1111/bjh.13631⟩

Plateforme de Bioinformatique de Toulouse Midi Pyrenées mobilisée dans cette recherche; International audience

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e8424abe1af004e54cc056ae8f2066a
https://hal.inrae.fr/hal-02633353