Výsledky vyhledávání - "Marina Bessarabova"

Akademický článek

An integrated map of HIV-human protein complexes that facilitate viral infection.

Autor: Dorothea Emig-Agius, Kevin Olivieri, Lars Pache, Hsin Ling Shih, Olga Pustovalova, Marina Bessarabova, John A T Young, Sumit K Chanda, Trey Ideker

Publikováno v: PLoS ONE, Vol 9, Iss 5, p e96687 (2014)

Recent proteomic and genetic studies have aimed to identify a complete network of interactions between HIV and human proteins and genes. This HIV-human interaction network provides invaluable information as to how HIV exploits the host machinery and

Externí odkaz: https://doaj.org/article/f29cbe97aeba42728eb5a4c5791daa8b

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Akademický článek

Systems-based analyses of brain regions functionally impacted in Parkinson's disease reveals underlying causal mechanisms.

Autor: Brigit E Riley, Shyra J Gardai, Dorothea Emig-Agius, Marina Bessarabova, Alexander E Ivliev, Birgitt Schüle, Jeff Alexander, William Wallace, Glenda M Halliday, J William Langston, Scott Braxton, Ted Yednock, Thomas Shaler, Jennifer A Johnston

Publikováno v: PLoS ONE, Vol 9, Iss 8, p e102909 (2014)

Detailed analysis of disease-affected tissue provides insight into molecular mechanisms contributing to pathogenesis. Substantia nigra, striatum, and cortex are functionally connected with increasing degrees of alpha-synuclein pathology in Parkinson'

Externí odkaz: https://doaj.org/article/75c932800ae34e25a56cae5f4cee04c5

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Akademický článek

Drug target prediction and repositioning using an integrated network-based approach.

Autor: Dorothea Emig, Alexander Ivliev, Olga Pustovalova, Lee Lancashire, Svetlana Bureeva, Yuri Nikolsky, Marina Bessarabova

Publikováno v: PLoS ONE, Vol 8, Iss 4, p e60618 (2013)

The discovery of novel drug targets is a significant challenge in drug development. Although the human genome comprises approximately 30,000 genes, proteins encoded by fewer than 400 are used as drug targets in the treatment of diseases. Therefore, n

Externí odkaz: https://doaj.org/article/c1267c8fc95848c0882f732266a9397b

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Akademický článek

Epigenetic regulation of cell type-specific expression patterns in the human mammary epithelium.

Autor: Reo Maruyama, Sibgat Choudhury, Adam Kowalczyk, Marina Bessarabova, Bryan Beresford-Smith, Thomas Conway, Antony Kaspi, Zhenhua Wu, Tatiana Nikolskaya, Vanessa F Merino, Pang-Kuo Lo, X Shirley Liu, Yuri Nikolsky, Saraswati Sukumar, Izhak Haviv, Kornelia Polyak

Publikováno v: PLoS Genetics, Vol 7, Iss 4, p e1001369 (2011)

Differentiation is an epigenetic program that involves the gradual loss of pluripotency and acquisition of cell type-specific features. Understanding these processes requires genome-wide analysis of epigenetic and gene expression profiles, which have

Externí odkaz: https://doaj.org/article/d4b3642e06ac4e1f994d1ffc664b3e25

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