Zobrazeno 1 - 4 of 4 pro vyhledávání: '"Marina Auth"'
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Soft drug-inhibitors for the epigenetic targets Lysine-Specific Demethylase 1 (LSD1) and Histone Deacetylases (HDACs)
Autor: Johannes Seitz, Marina Auth, Pavlos Tzortzoglou, Mirjam Hau, Johannes Schulz-Fincke, Dominica Willmann, Eric Metzger, Roland Schüle, Manfred Jung
Epigenetic modulators such as Lysine-specific Demethylase 1 (LSD1) and Histone Deacetylases (HDACs), are drug targets for cancer, neuropsychatric disease or inflammation but inhibitors of these enzymes exhibit considerable side effects. For a potenti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::62d742a23d8f19e887f201859e8345d2
https://doi.org/10.26434/chemrxiv-2022-n11dq
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2
Mechanism-Based Inhibitors of the Human Sirtuin 5 Deacylase: Structure-Activity Relationship, Biostructural, and Kinetic Insight
Autor: Christian A. Olsen, Andreas Stahl Madsen, Marina Auth, Clemens Steegborn, Nima Rajabi, Dhaval P. Bhatt, Matthew D. Hirschey, Kathrin R. Troelsen, Martin Pannek, Martin Fontenas
Publikováno v: Angewandte Chemie International Edition
The sirtuin enzymes are important regulatory deacylases in a variety of biochemical contexts and may therefore be potential therapeutic targets through either activation or inhibition by small molecules. Here, we describe the discovery of the most po
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2242c0995958e1e205248bc4f9dbd475
https://doi.org/10.1002/anie.201709050
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