Zobrazeno 1 - 10 of 29 pro vyhledávání: '"Marina Asher"'
1
Akademický článek
Genomic and transcriptomic analysis of a library of small cell lung cancer patient-derived xenografts
Autor: Rebecca Caeser, Jacklynn V. Egger, Shweta Chavan, Nicholas D. Socci, Caitlin Byrne Jones, Faruk Erdem Kombak, Marina Asher, Michael H. Roehrl, Nisargbhai S. Shah, Viola Allaj, Parvathy Manoj, Sam E. Tischfield, Amanda Kulick, Maximiliano Meneses, Christine A. Iacobuzio-Donahue, W. Victoria Lai, Umeshkumar Bhanot, Marina K. Baine, Natasha Rekhtman, Travis J. Hollmann, Elisa de Stanchina, John T. Poirier, Charles M. Rudin, Triparna Sen
Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Creating accurate models of small cell lung cancer is essential to ensure the clinical relevance of results. Here, the authors create patient derived xenograft models from 33 patients and show, through multi-omics sequencing, that these models retain
Externí odkaz: https://doaj.org/article/6db844e570e04ea595ba52c8f6bba923
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3
Akademický článek
MAPK pathway activation selectively inhibits ASCL1-driven small cell lung cancer
Autor: Rebecca Caeser, Christopher Hulton, Emily Costa, Vidushi Durani, Megan Little, Xiaoping Chen, Sam E. Tischfield, Marina Asher, Faruk Erdem Kombak, Shweta S. Chavan, Nisargbhai S. Shah, Metamia Ciampricotti, Elisa de Stanchina, John T. Poirier, Charles M. Rudin, Triparna Sen
Publikováno v: iScience, Vol 24, Iss 11, Pp 103224- (2021)
Summary: Activation of mitogenic signaling pathways is a common oncogenic driver of many solid tumors including lung cancer. Although activating mutations in the mitogen-activated protein kinase (MAPK) pathway are prevalent in non-small cell lung can
Externí odkaz: https://doaj.org/article/408084487e324b9abf64eba52e8ffc2a
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4
Akademický článek
Concurrent Mutations in STK11 and KEAP1 Promote Ferroptosis Protection and SCD1 Dependence in Lung Cancer
Autor: Corrin A. Wohlhieter, Allison L. Richards, Fathema Uddin, Christopher H. Hulton, Àlvaro Quintanal-Villalonga, Axel Martin, Elisa de Stanchina, Umeshkumar Bhanot, Marina Asher, Nisargbhai S. Shah, Omar Hayatt, Darren J. Buonocore, Natasha Rekhtman, Ronglai Shen, Kathryn C. Arbour, Mark Donoghue, John T. Poirier, Triparna Sen, Charles M. Rudin
Publikováno v: Cell Reports, Vol 33, Iss 9, Pp 108444- (2020)
Summary: Concurrent loss-of-function mutations in STK11 and KEAP1 in lung adenocarcinoma (LUAD) are associated with aggressive tumor growth, resistance to available therapies, and early death. We investigated the effects of coordinate STK11 and KEAP1
Externí odkaz: https://doaj.org/article/79f1bb5015774d05860c9599ee982825
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