Zobrazeno 1 - 10
of 239
pro vyhledávání: '"Marina A. Zenkova"'
Autor:
Kirill V. Odarenko, Aleksandra V. Sen’kova, Oksana V. Salomatina, Oleg V. Markov, Nariman F. Salakhutdinov, Marina A. Zenkova, Andrey V. Markov
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Soloxolone amides are semisynthetic triterpenoids that can cross the blood-brain barrier and inhibit glioblastoma growth both in vitro and in vivo. Here we investigate the impact of these compounds on processes associated with glioblastoma invasivene
Externí odkaz:
https://doaj.org/article/8bda56d571fa47af9a22c1eedf902d68
Autor:
Arseny D. Moralev, Oksana V. Salomatina, Ivan V. Chernikov, Nariman F. Salakhutdinov, Marina A. Zenkova, Andrey V. Markov
Publikováno v:
ACS Omega, Vol 8, Iss 51, Pp 48813-48824 (2023)
Externí odkaz:
https://doaj.org/article/97f53e210b5b4b3c8c867f70daf22953
Autor:
Arseny D. Moralev, Oksana V. Salomatina, Nariman F. Salakhutdinov, Marina A. Zenkova, Andrey V. Markov
Publikováno v:
Molecules, Vol 29, Iss 20, p 4939 (2024)
Multidrug resistance (MDR) remains a significant challenge in cancer therapy, primarily due to the overexpression of transmembrane drug transporters, with P-glycoprotein (P-gp) being a central focus. Consequently, the development of P-gp inhibitors h
Externí odkaz:
https://doaj.org/article/99f440c0327c4dca97ff2cc2a61798c4
Publikováno v:
Molecules, Vol 29, Iss 13, p 3225 (2024)
A short 19 bp dsRNA with 3′-trinucleotide overhangs acting as immunostimulating RNA (isRNA) demonstrated strong antiproliferative action against cancer cells, immunostimulatory activity through activation of cytokines and Type-I IFN secretion, as w
Externí odkaz:
https://doaj.org/article/c6aabba104144e50b02e58a6ee79e1f2
Autor:
Ivan V. Chernikov, Irina K. Bachkova, Aleksandra V. Sen’kova, Mariya I. Meschaninova, Innokenty A. Savin, Valentin V. Vlassov, Marina A. Zenkova, Elena L. Chernolovskaya
Publikováno v:
Cells, Vol 13, Iss 9, p 767 (2024)
Small interfering RNA (siRNA) holds significant therapeutic potential by silencing target genes through RNA interference. Current clinical applications of siRNA have been primarily limited to liver diseases, while achievements in delivery methods are
Externí odkaz:
https://doaj.org/article/df86cd36ee1a45d0b8013056b41765d0
Autor:
Ivan V. Chernikov, Ul’yana A. Ponomareva, Mariya I. Meschaninova, Irina K. Bachkova, Valentin V. Vlassov, Marina A. Zenkova, Elena L. Chernolovskaya
Publikováno v:
Molecules, Vol 29, Iss 4, p 786 (2024)
Cholesterol siRNA conjugates attract attention because they allow the delivery of siRNA into cells without the use of transfection agents. In this study, we compared the efficacy and duration of silencing induced by cholesterol conjugates of selectiv
Externí odkaz:
https://doaj.org/article/a9812619882e4165812a0c26a5a07816
Autor:
Aleksandra V. Sen’kova, Innokenty A. Savin, Kirill V. Odarenko, Oksana V. Salomatina, Nariman F. Salakhutdinov, Marina A. Zenkova, Andrey V. Markov
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 159, Iss , Pp 114231- (2023)
The anti-inflammatory potential of three cyanoenone-containing triterpenoids, including soloxolone methyl (SM), soloxolone (S) and its novel derivative bearing at the C-30 amidoxime moiety (SAO), was studied in murine models of acute inflammation. It
Externí odkaz:
https://doaj.org/article/dd31faf759084084a5cc958885ce95d9
Autor:
Maxim S. Kupryushkin, Anton V. Filatov, Nadezhda L. Mironova, Olga A. Patutina, Ivan V. Chernikov, Elena L. Chernolovskaya, Marina A. Zenkova, Dmitrii V. Pyshnyi, Dmitry A. Stetsenko, Sidney Altman, Valentin V. Vlassov
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 27, Iss , Pp 211-226 (2022)
Antisense gapmer oligonucleotides containing phosphoryl guanidine (PG) groups, e.g., 1,3-dimethylimidazolidin-2-imine, at three to five internucleotidic positions adjacent to the 3′ and 5′ ends were prepared via the Staudinger chemistry, which is
Externí odkaz:
https://doaj.org/article/c83f7d0cf88a49389f1c3548b177f3e2
Autor:
Kirill V. Odarenko, Oksana V. Salomatina, Ivan V. Chernikov, Nariman F. Salakhutdinov, Marina A. Zenkova, Andrey V. Markov
Publikováno v:
Pharmaceuticals, Vol 16, Iss 10, p 1369 (2023)
Despite the proven tumorigenic effect of leptin on epithelial-derived cancers, its impact on the aggressiveness of neural crest-derived cancers, notably neuroblastoma, remains largely unexplored. In our study, for the first time, transcriptome analys
Externí odkaz:
https://doaj.org/article/bb9693f1040e4e129c5b5696f6b6a6ab
Influence of the Composition of Cationic Liposomes on the Performance of Cargo Immunostimulatory RNA
Autor:
Ali Bishani, Darya M. Makarova, Elena V. Shmendel, Mikhail A. Maslov, Aleksandra V. Sen‘kova, Innokenty A. Savin, Daniil V. Gladkikh, Marina A. Zenkova, Elena L. Chernolovskaya
Publikováno v:
Pharmaceutics, Vol 15, Iss 9, p 2184 (2023)
In this study, the impact of different delivery systems on the cytokine-inducing, antiproliferative, and antitumor activities of short immunostimulatory double-stranded RNA (isRNA) was investigated. The delivery systems, consisting of the polycationi
Externí odkaz:
https://doaj.org/article/59a02d77ecb24d2b8dd56541fe8cdb95