Asymmetric Synthesis of trans-3-Alkoxyamino-4-Oxygenated-2-Piperidones Mediated by Transition-Metal-Free Dual C-H Oxidation and Its CAL-B-Assisted Enzymatic Resolution

Autor: Julio Romero-Ibañez, Marina A. Ortega-Rojas, Jonathan R. Valdéz-Camacho, Luis G. Hernández-Vázquez, Fernando Sartillo-Piscil, Jaime Escalante

Publikováno v: Catalysts; Volume 13; Issue 4; Pages: 703

A general chemo-enzymatic approach to synthesize both enantioenriched trans-3-alkoxyamino-4-oxy-2-piperidones, which are important scaffold for various naturally occurring alkaloids, is reported. To this end, a selective transition-metal-free dual C�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::167e8db3a488395df7e6fa5da21b44e9
https://doi.org/10.3390/catal13040703

One-Pot Lipase-Catalyzed Enantioselective Synthesis of (R)-(−)-N-Benzyl-3-(benzylamino)butanamide: The Effect of Solvent Polarity on Enantioselectivity

Autor: José Domingo Rivera-Ramírez, C. Gabriela Avila-Ortiz, Eusebio Juaristi, Marina A Ortega-Rojas, Edmundo Castillo, Jaime Escalante, Fernando González-Muñoz

Publikováno v: Molecules, Vol 22, Iss 12, p 2189 (2017)
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Molecules; Volume 22; Issue 12; Pages: 2189

The use of the solvent engineering has been applied for controlling the resolution of lipase-catalyzed synthesis of β-aminoacids via Michael addition reactions. The strategy consisted of the thermodynamic control of products at equilibrium using the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::111e55f67a2901392e7db98533931f62
https://www.mdpi.com/1420-3049/22/12/2189