Zobrazeno 1 - 10
of 264
pro vyhledávání: '"Marina A, Lynch"'
Autor:
Marina A. Lynch
Publikováno v:
Frontiers in Aging Neuroscience, Vol 16 (2024)
There is no satisfactory explanation for the sex-related differences in the incidence of many diseases and this is also true of Alzheimer’s disease (AD), where females have a higher lifetime risk of developing the disease and make up about two thir
Externí odkaz:
https://doaj.org/article/9b5238c3e3e84e52b44fb90fc43e1ae8
Autor:
Marie-Victoire Guillot-Sestier, Ana Rubio Araiz, Virginia Mela, Aline Sayd Gaban, Eoin O’Neill, Lisha Joshi, Edward T. Chouchani, Evanna L. Mills, Marina A. Lynch
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Guillot-Sestier et al investigated sex-related differences in microglia in postmortem brain tissue from Alzheimer’s Disease (AD) patients as well as in the APP/PS1 AD mouse model. They demonstrated that there was differential expression of genes as
Externí odkaz:
https://doaj.org/article/a001442647c94de9a36e380d0601a7a1
Autor:
Eoin O’Neill, Virginia Mela, Aline Sayd Gaban, Sibylle Bechet, Aoife McGrath, Aife Walsh, Allison McIntosh, Marina A. Lynch
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Many studies implicate microglia in the pathogenesis of Alzheimer’s disease (AD) but precisely how these cells make their impact has not been determined to date. One contributory factor is likely to be the enhanced production of inflammatory mediat
Externí odkaz:
https://doaj.org/article/52af470307374b01b1ed061ed44c1e18
Autor:
Marina A. Lynch
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
One area of microglial biology that has been relatively neglected until recently is sex differences and this is in spite of the fact that sex is a risk factor in several diseases that are characterized by neuroinflammation and, by extension, microgli
Externí odkaz:
https://doaj.org/article/5135cb6628844653b7cd32405a79f658
Autor:
Virginia Mela, Aline Sayd Gaban, Paul Marie Shatz, Marie-Victoire Guillot-Sestier, Marina A. Lynch
Publikováno v:
Molecular Neurobiology. 60:3044-3053
Microglial phenotype changes in the aged brain, and also in neurodegenerative diseases, and it is generally accepted that these changes at least contribute to the inflammation that can have detrimental effects on brain health. Accumulating data have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1d39aaf2fc62d8c2076accf4302eb19
https://doi.org/10.1007/s12035-023-03235-9
https://doi.org/10.1007/s12035-023-03235-9
Publikováno v:
Cells, Vol 11, Iss 4, p 729 (2022)
There is a striking sex-related difference in the prevalence of many neurodegenerative diseases, highlighting the need to consider whether treatments may exert sex-specific effects. A change in microglial activation state is a common feature of sever
Externí odkaz:
https://doaj.org/article/19984fd8015e49a0ab14c59270944b43
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-13 (2018)
Abstract Background Microglia are multifunctional cells that are primarily neuroprotective and a deficit in their functional integrity is likely to be a contributory factor in the deteriorating neuronal function that occurs with age and neurodegenera
Externí odkaz:
https://doaj.org/article/5cb41c9d54f640ea9e7ae5113c6feb58
Autor:
Marina A. Lynch, Virginia Mela, Kingston H. G. Mills, Mark Milner, Bibiana C Mota, Áine M. Kelly, Aoife M. McGinley
Publikováno v:
Brain, Behavior, and Immunity. 87:413-428
Microglial activation and neuroinflammatory changes are characteristic of the aged brain and contribute to age-related cognitive impairment. Exercise improves cognitive function in aged animals, perhaps because of a modulatory effect on microglial ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d5f0c483a1b7ae1e0ccf34f38c45f95
https://doi.org/10.1016/j.bbi.2020.01.012
https://doi.org/10.1016/j.bbi.2020.01.012
Autor:
A. McIntosh, Marina A. Lynch, Aedín M. Minogue, Derek A. Costello, Virginia Mela, Christian Kerskens, Conor Harty
Publikováno v:
Brain Pathol
Among the changes that typify Alzheimer’s disease (AD) are neuroinflammation and microglial activation, amyloid deposition perhaps resulting from compromised microglial function and iron accumulation. Data from Genome Wide Association Studies (GWAS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82aae113586a0a619b34aa3720ddac0f
https://doi.org/10.1111/bpa.12704
https://doi.org/10.1111/bpa.12704
Autor:
Eleonora Distrutti, Julie-Ann O'Reilly, Claire McDonald, Sabrina Cipriani, Barbara Renga, Marina A Lynch, Stefano Fiorucci
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e106503 (2014)
The intestinal microbiota is increasingly recognized as a complex signaling network that impacts on many systems beyond the enteric system modulating, among others, cognitive functions including learning, memory and decision-making processes. This ha
Externí odkaz:
https://doaj.org/article/21b96d65b0e144e0a529f6fb0bae2b22