Zobrazeno 1 - 10
of 1 729
pro vyhledávání: '"Marina Konopleva"'
Autor:
Bofei Wang, Patrick K. Reville, Mhd Yousuf Yassouf, Fatima Z. Jelloul, Christopher Ly, Poonam N. Desai, Zhe Wang, Pamella Borges, Ivo Veletic, Enes Dasdemir, Jared K. Burks, Guilin Tang, Shengnan Guo, Araceli Isabella Garza, Cedric Nasnas, Nicole R. Vaughn, Natalia Baran, Qing Deng, Jairo Matthews, Preethi H. Gunaratne, Dinler A. Antunes, Suhendan Ekmekcioglu, Koji Sasaki, Miriam B. Garcia, Branko Cuglievan, Dapeng Hao, Naval Daver, Michael R. Green, Marina Konopleva, Andrew Futreal, Sean M. Post, Hussein A. Abbas
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Interferon gamma (IFNγ) is a critical cytokine known for its diverse roles in immune regulation, inflammation, and tumor surveillance. However, while IFNγ levels were elevated in sera of most newly diagnosed acute myeloid leukemia (AML) pa
Externí odkaz:
https://doaj.org/article/03859817a55c485c9cfde6439e811923
Autor:
Natthakan Thongon, Feiyang Ma, Natalia Baran, Pamela Lockyer, Jintan Liu, Christopher Jackson, Ashley Rose, Ken Furudate, Bethany Wildeman, Matteo Marchesini, Valentina Marchica, Paola Storti, Giannalisa Todaro, Irene Ganan-Gomez, Vera Adema, Juan Jose Rodriguez-Sevilla, Yun Qing, Min Jin Ha, Rodrigo Fonseca, Caleb Stein, Caleb Class, Lin Tan, Sergio Attanasio, Guillermo Garcia-Manero, Nicola Giuliani, David Berrios Nolasco, Andrea Santoni, Claudio Cerchione, Carlos Bueso-Ramos, Marina Konopleva, Philip Lorenzi, Koichi Takahashi, Elisabet Manasanch, Gabriella Sammarelli, Rashmi Kanagal-Shamanna, Andrea Viale, Marta Chesi, Simona Colla
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract DNA damage resistance is a major barrier to effective DNA-damaging therapy in multiple myeloma (MM). To discover mechanisms through which MM cells overcome DNA damage, we investigate how MM cells become resistant to antisense oligonucleotide
Externí odkaz:
https://doaj.org/article/0ff32e3e332a47feb2ca0404a6595cec
Autor:
Do Hwan Kim, Sa A. Wang, Wei Wang, Guilin Tang, Shaoying Li, C. Cameron Yin, Pei Lin, Marina Konopleva, M. James You, Roberto N. Miranda, Xiaoqiong Wang, Qing Wei, L. Jeffrey Medeiros, Jie Xu
Publikováno v:
Haematologica, Vol 999, Iss 1 (2024)
Not available.
Externí odkaz:
https://doaj.org/article/ffdd5b7667ee4a58a9fc286862766377
Autor:
Tarang Gaur, Ramulu Poddutoori, Leena Khare, Bhausaheb Bagal, Sonal Rashmi, Nikhil Patkar, Prashant Tembhare, Subramanian PG, Dhanlaxmi Shetty, Amit Dutt, Qi Zhang, Marina Konopleva, Uwe Platzbeckar, Sudeep Gupta, Susanta Samajdar, Murali Ramchandra, Navin Khattry, Syed K. Hasan
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-20 (2023)
Abstract Introduction The emergence of resistance to the highly successful BCL2-directed therapy is a major unmet need in acute myeloid leukemia (AML), an aggressive malignancy with poor survival rates. Towards identifying therapeutic options for AML
Externí odkaz:
https://doaj.org/article/54d80639d7f1473994ede58e53e22e10
Autor:
John X. Wei, Marina Konopleva
Publikováno v:
Frontiers in Hematology, Vol 2 (2023)
Apoptosis is a tightly regulated process of cell death occurring through extrinsic and intrinsic pathways. The Bcl-2 family of proteins is implicated in the intrinsic pathway and encompasses both pro-apoptotic and anti-apoptotic proteins. Anti-apopto
Externí odkaz:
https://doaj.org/article/f318650f9c32431aa4ea14bff7ce4768
Autor:
Patrick Williams, Mien-Chie Hung, Jennifer L Hsu, Marina Konopleva, Michael A Curran, Zhou Jiang, Natalia Baran, Xuelin Huang, Renee L Chin, Paul Koller, Karine Harutyunyan, Antonio Cavazos, Saradhi Mallampati, Xian Sun, Heng-Huan Lee
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 10 (2023)
Immunotherapy, in the form of hematopoietic stem cell transplantation (HSCT), has been part of the standard of care in the treatment of acute leukemia for over 40 years. Trials evaluating novel immunotherapeutic approaches, such as targeting the prog
Externí odkaz:
https://doaj.org/article/06f9760e8f224e8692cf4a2fe706fc4a
Autor:
Muhammad Aminu, Naval Daver, Myrna C. B. Godoy, Girish Shroff, Carol Wu, Luis F. Torre-Sada, Alberto Goizueta, Vickie R. Shannon, Saadia A. Faiz, Mehmet Altan, Guillermo Garcia-Manero, Hagop Kantarjian, Farhad Ravandi-Kashani, Tapan Kadia, Marina Konopleva, Courtney DiNardo, Sherry Pierce, Aung Naing, Sang T. Kim, Dimitrios P. Kontoyiannis, Fareed Khawaja, Caroline Chung, Jia Wu, Ajay Sheshadri
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundImmune checkpoint inhibitors (ICI) may cause pneumonitis, resulting in potentially fatal lung inflammation. However, distinguishing pneumonitis from pneumonia is time-consuming and challenging. To fill this gap, we build an image-based tool
Externí odkaz:
https://doaj.org/article/5911f198a840450f805d8a3fd64d53af
Autor:
Xujie Zhao, Ping Wang, Jonathan D. Diedrich, Brandon Smart, Noemi Reyes, Satoshi Yoshimura, Jingliao Zhang, Wentao Yang, Kelly Barnett, Beisi Xu, Zhenhua Li, Xin Huang, Jiyang Yu, Kristine Crews, Allen Eng Juh Yeoh, Marina Konopleva, Chia-Lin Wei, Ching-Hon Pui, Daniel Savic, Jun J. Yang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Different molecular subtypes defined by specific gene rearrangements have been described for acute lymphoblastic leukaemia (ALL). Here, the authors show that ZNF384 fusion activates FLT3 expression conferring a therapeutic vulnerability for ZNF384- r
Externí odkaz:
https://doaj.org/article/d14b4f6c096c49f694347dc01d940e14
Autor:
Nicholas Short, Elias Jabbour, Nitin Jain, Xuelin Huang, Walid Macaron, Lewis Nasr, Guillermo Montalban-Bravo, Tapan Kadia, Naval Daver, Kelly Chien, Yesid Alvarado, Ghayas Issa, Fadi Haddad, Cedric Nasnas, Marianne Zoghbi, Rebecca Garris, Marina Konopleva, Farhad Ravandi, Hagop Kantarjian
Publikováno v:
HemaSphere, Vol 7, p e4968152 (2023)
Externí odkaz:
https://doaj.org/article/0e963ace8d9546068c96342d83fe8441
Autor:
Nicholas Short, Elias Jabbour, Nitin Jain, Fadi Haddad, Musa Yilmaz, Lewis Nasr, Alessandra Ferrajoli, Tapan Kadia, Yesid Alvarado, Abhishek Maiti, Walid Macaron, Marianne Zoghbi, Cedric Nasnas, Rebecca Garris, Min Zhao, Marina Konopleva, Farhad Ravandi, Hagop Kantarjian
Publikováno v:
HemaSphere, Vol 7, p e67564ca (2023)
Externí odkaz:
https://doaj.org/article/e12ac26c73fd4ebd8d655a265fd630d3