Výsledky vyhledávání - "Marina, Porchia"

Akademický článek

In vitro and in vivo activity of a hypotoxic copper(I) complex against dermotropic Leishmania species

Autor: Ana Flávia da Silva CHAGAS, Marina PORCHIA, Thaís Pinto NASCIMENTO, Carolina Nunes Souza CORREA, Anny Maíza Vargas BRASIL, Antonia Maria Ramos FRANCO

Publikováno v: Acta Amazonica, Vol 51, Iss 3, Pp 260-269 (2021)

ABSTRACT Cutaneous leishmaniasis is a disease caused by protozoa of the genus Leishmania and, currently, the treatment of first choice is meglumine antimoniate. However, due to its limited effectiveness and high toxicity, it is necessary to seek new

Externí odkaz: https://doaj.org/article/364b644031db487ca69f0b6bcac39a64

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Akademický článek

In vitro and in vivo Anti-leishmanial Potential of [Ag (PTA) 4 ]BF 4 and [Ag(HBPz 3 )(PPh 3 )] Silver Complexes

Autor: Pauline de Faria Soldera, Ana Flavia da Silva Chagas, Anny Maisa Vargas Brasil, Claudia Dantas Comandolli-Wyrepkowski, Marina Porchia, Antonia Maria Ramos Franco Pereira

Publikováno v: Revista da Sociedade Brasileira de Medicina Tropical, Vol 55 (2022)

ABSTRACT Background: American tegumentary leishmaniasis is a parasitic disease known for being difficult to treat; therefore, the search for more effective therapeutic methods is necessary. The objective of this study was to evaluate the in vitro and

Externí odkaz: https://doaj.org/article/f8c74c396ee1484c83b87618dbc3de79

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Akademický článek

In vitro antitumor activity of water-soluble copper(I) complexes with diimine and monodentate phosphine ligands

Autor: Marina Porchia, Francesco Tisato, Mirella Zancato, Valentina Gandin, Cristina Marzano

Publikováno v: Arabian Journal of Chemistry, Vol 13, Iss 1, Pp 998-1010 (2020)

Copper(I) complexes including diimine ligands of the bicinchoninic acid (BCA) and bathocuproinedisulfonic acid (BCS) families and water-soluble phosphines have been synthetized, characterized and investigated for their in vitro anticancer potential a

Externí odkaz: https://doaj.org/article/338bcf591eb24d1693116563afec2ea2

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Akademický článek

Two out of Three Musketeers Fight against Cancer: Synthesis, Physicochemical, and Biological Properties of Phosphino CuI, RuII, IrIII Complexes

Autor: Urszula K. Komarnicka, Alessandro Niorettini, Sandra Kozieł, Barbara Pucelik, Agata Barzowska, Daria Wojtala, Aleksandra Ziółkowska, Monika Lesiów, Agnieszka Kyzioł, Stefano Caramori, Marina Porchia, Alina Bieńko

Publikováno v: Pharmaceuticals, Vol 15, Iss 2, p 169 (2022)

Two novel phosphine ligands, Ph2PCH2N(CH2CH3)3 (1) and Ph2PCH2N(CH2CH2CH2CH3)2 (2), and six new metal (Cu(I), Ir(III) and Ru(II)) complexes with those ligands: iridium(III) complexes: Ir(η5-Cp*)Cl2(1) (1a), Ir(η5-Cp*)Cl2(2) (2a) (Cp*: Pentamethylcy

Externí odkaz: https://doaj.org/article/2d4a5e7f47bd43cf8a4866f9b1c33959

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Akademický článek

Zinc Complexes with Nitrogen Donor Ligands as Anticancer Agents

Autor: Marina Porchia, Maura Pellei, Fabio Del Bello, Carlo Santini

Publikováno v: Molecules, Vol 25, Iss 24, p 5814 (2020)

The search for anticancer metal-based drugs alternative to platinum derivatives could not exclude zinc derivatives due to the importance of this metal for the correct functioning of the human body. Zinc, the second most abundant trace element in the

Externí odkaz: https://doaj.org/article/f55f4c17fa104f0991965cb99b69023d

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Akademický článek

Antiproliferative Homoleptic and Heteroleptic Phosphino Silver(I) Complexes: Effect of Ligand Combination on Their Biological Mechanism of Action

Autor: Khouloud Dammak, Marina Porchia, Michele De Franco, Mirella Zancato, Houcine Naïli, Valentina Gandin, Cristina Marzano

Publikováno v: Molecules, Vol 25, Iss 22, p 5484 (2020)

A series of neutral mixed-ligand [HB(pz)3]Ag(PR3) silver(I) complexes (PR3 = tertiary phosphine, [HB(pz)3]− = tris(pyrazolyl)borate anion), and the corresponding homoleptic [Ag(PR3)4]BF4 compounds have been synthesized and fully characterized. Silv

Externí odkaz: https://doaj.org/article/dac88ea5053545cc91834ed734451ca7

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Akademický článek

Highly Hydrophilic Gold Nanoparticles as Carrier for Anticancer Copper(I) Complexes: Loading and Release Studies for Biomedical Applications

Autor: Ilaria Fratoddi, Iole Venditti, Chiara Battocchio, Laura Carlini, Simone Amatori, Marina Porchia, Francesco Tisato, Federica Bondino, Elena Magnano, Maura Pellei, Carlo Santini

Publikováno v: Nanomaterials, Vol 9, Iss 5, p 772 (2019)

Gold nanoparticles (AuNPs), which are strongly hydrophilic and dimensionally suitable for drug delivery, were used in loading and release studies of two different copper(I)-based antitumor complexes, namely [Cu(PTA)4]+ [BF4]− (A; PTA = 1, 3, 5-tria

Externí odkaz: https://doaj.org/article/ff24273a39ba4db59d26d6bcc853edf6

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In vitro antitumor activity of water-soluble copper(I) complexes with diimine and monodentate phosphine ligands

Autor: Mirella Zancato, Valentina Gandin, Marina Porchia, Francesco Tisato, Cristina Marzano

Publikováno v: Arabian Journal of Chemistry, Vol 13, Iss 1, Pp 998-1010 (2020)
Arabian journal of chemistry (Online) 13 (2020): 998–1010. doi:10.1016/j.arabjc.2017.09.003
info:cnr-pdr/source/autori:Porchia M.; Tisato F.; Zancato M.; Gandin V.; Marzano C./titolo:In vitro antitumor activity of water-soluble copper(I) complexes with diimine and monodentate phosphine ligands/doi:10.1016%2Fj.arabjc.2017.09.003/rivista:Arabian journal of chemistry (Online)/anno:2020/pagina_da:998/pagina_a:1010/intervallo_pagine:998–1010/volume:13

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e20ae960251174f5d958cf968578d318
http://www.sciencedirect.com/science/article/pii/S1878535217301715

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Coordinative unsaturated CuI entities are crucial intermediates governing cell internalization of copper. A combined experimental ESI-MS and DFT study

Autor: Karolina Bossak-Ahmad, Francesco Tisato, Maurizio Casarin, Marina Porchia, Wojciech Bal, Silvia Carlotto, Arkadiusz Bonna

Publikováno v: Metallomics (Online) 11 (2019): 1800–1804. doi:10.1039/C9MT00236G
info:cnr-pdr/source/autori:Carlotto S.; Bonna A.; Bossak-Ahmad K.; Bal W.; Porchia M.; Casarin M.; Tisato F./titolo:Coordinative unsaturated CuI entities are crucial intermediates governing cell internalization of copper. A combined experimental ESI-MS and DFT study./doi:10.1039%2FC9MT00236G/rivista:Metallomics (Online)/anno:2019/pagina_da:1800/pagina_a:1804/intervallo_pagine:1800–1804/volume:11

Model peptides relevant to hCtr1 transchelate CuI from the anti-tumour [CuI(PTA)4]+ complex before metal internalization into tumor cells. ESI(+)MS experiments corroborated by DFT calculations indicate that tetracoordinated-CuII and linear-CuI arrang

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8ce109b92fb74b1bb377bf14cfc923a
https://doi.org/10.1039/c9mt00236g

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Copper Complexes as Anticancer Agents

Autor: Michele Franco, Marina Porchia, Francesco Tisato, Cristina Marzano, Valentina Gandin

Publikováno v: pp. 1–21. New York: J. Wiley & sons, 2021
info:cnr-pdr/source/autori:Michele De Franco, Cristina Marzano & Valentina Gandin Marina Porchia & Francesco Tisato/titolo:Copper Complexes as Anticancer Agents/titolo_volume:/curatori_volume:/editore: /anno:2021

In the search for new effective metal-based agents to address requirements for anticancer therapy, recent studies demonstrated that copper complexes represent valuable alternatives to currently clinically used Pt(II) drugs.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::812ac04ea4d6a7ce9d26a8183ae6c399
http://www.cnr.it/prodotto/i/462731

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