Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Marina, Mione"'
Autor:
Ilaria Rosso, Corey Jones-Weinert, Francesca Rossiello, Matteo Cabrini, Silvia Brambillasca, Leonel Munoz-Sagredo, Zeno Lavagnino, Emanuele Martini, Enzo Tedone, Massimiliano Garre’, Julio Aguado, Dario Parazzoli, Marina Mione, Jerry W. Shay, Ciro Mercurio, Fabrizio d’Adda di Fagagna
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Alternative lengthening of telomeres (ALT) is a telomere maintenance mechanism activated in ~10–15% of cancers, characterized by telomeric damage. Telomeric damage-induced long non-coding RNAs (dilncRNAs) are transcribed at dysfunctional t
Externí odkaz:
https://doaj.org/article/96aecb24e77f4ab3b16b729a382e090c
Autor:
Indre Piragyte, Thomas Clapes, Aikaterini Polyzou, Ramon I. Klein Geltink, Stylianos Lefkopoulos, Na Yin, Pierre Cauchy, Jonathan D. Curtis, Lhéanna Klaeylé, Xavier Langa, Cora C. A. Beckmann, Marcin W. Wlodarski, Patrick Müller, Dominic Van Essen, Angelika Rambold, Friedrich G. Kapp, Marina Mione, Joerg M. Buescher, Erika L. Pearce, Alexander Polyzos, Eirini Trompouki
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
HLX transcription factor regulates haematopoietic stem and progenitor cell (HSPC) differentiation and is overexpressed in acute myeloid leukemia. Here the authors show that HLX overexpression leads to myeloid differentiation block in zebrafish and hu
Externí odkaz:
https://doaj.org/article/6e1870de09fa401dacacea3d50a2697e
Autor:
Marie Mayrhofer, Victor Gourain, Markus Reischl, Pierre Affaticati, Arnim Jenett, Jean-Stephane Joly, Matteo Benelli, Francesca Demichelis, Pietro Luigi Poliani, Dirk Sieger, Marina Mione
Publikováno v:
Disease Models & Mechanisms, Vol 10, Iss 1, Pp 15-28 (2017)
Somatic mutations activating MAPK and PI3K signalling play a pivotal role in both tumours and brain developmental disorders. We developed a zebrafish model of brain tumours based on somatic expression of oncogenes that activate MAPK and PI3K signalli
Externí odkaz:
https://doaj.org/article/6ea228aad95c4f3bb6d9f799cee87c3c
Autor:
Viani, Alex Pezzotta, Loredana Brioschi, Sabrina Carbone, Beatrice Mazzoleni, Vittorio Bontempi, Federica Monastra, Laura Mauri, Anna Marozzi, Marina Mione, Anna Pistocchi, Paola
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 6; Pages: 5771
Glioblastoma multiforme (GBM) is the most common and malignant brain tumor in adults. The invasiveness and the rapid progression that characterize GBM negatively impact patients’ survival. Temozolomide (TMZ) is currently considered the first-choice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::d413183c9315e216cb3b22c78dc0425e
Autor:
Viviana Anelli, Anita Ordas, Susanne Kneitz, Leonel Munoz Sagredo, Victor Gourain, Manfred Schartl, Annemarie H. Meijer, Marina Mione
Publikováno v:
Frontiers in Genetics, Vol 9 (2018)
Ras genes are among the most commonly mutated genes in human cancer; yet our understanding of their oncogenic activity at the molecular mechanistic level is incomplete. To identify downstream events that mediate ras-induced cellular transformation in
Externí odkaz:
https://doaj.org/article/b2454468f17d4d9babc9791b2eb3b4d5
Publikováno v:
eLife, Vol 7 (2018)
It is now clear that microglia and macrophages are present in brain tumors, but whether or how they affect initiation and development of tumors is not known. Exploiting the advantages of the zebrafish (Danio rerio) model, we showed that macrophages a
Externí odkaz:
https://doaj.org/article/255d8380a6f1430295963321963effef
Autor:
Maria Solange Ibarra, Carla Borini Etichetti, Carolina Di Benedetto, Germán L Rosano, Ezequiel Margarit, Giannino Del Sal, Marina Mione, Javier Girardini
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0175939 (2017)
The prolyl isomerase Pin1 plays a key role in the modulation of proline-directed phosphorylation signaling by inducing local conformational changes in phosphorylated protein substrates. Extensive studies showed different roles for Pin1 in physiologic
Externí odkaz:
https://doaj.org/article/5f6106546d0f46369ca0b530ccc3e8f7
Autor:
Valentina Biagini, Federica Busi, Viviana Anelli, Emanuela Kerschbamer, Marta Baghini, Elena Gurrieri, Michela Notarangelo, Isabella Pesce, Guillaume van Niel, Vito G. D’Agostino, Marina Mione
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, MDPI, 2022, 23 (10), pp.5510. ⟨10.3390/ijms23105510⟩
International Journal of Molecular Sciences; Volume 23; Issue 10; Pages: 5510
International Journal of Molecular Sciences, MDPI, 2022, 23 (10), pp.5510. ⟨10.3390/ijms23105510⟩
International Journal of Molecular Sciences; Volume 23; Issue 10; Pages: 5510
International audience; Extracellular vesicles (EVs) are membranous particles released by all cell types. Their role as functional carrier of bioactive molecules is boosted by cells that actively secrete them in biological fluids or in the intercellu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68ad4a617f3e19f9ada9b7b75860ed0a
https://pubmed.ncbi.nlm.nih.gov/35628321
https://pubmed.ncbi.nlm.nih.gov/35628321
Publikováno v:
PLoS Biology, Vol 14, Iss 2, p e1002377 (2016)
Externí odkaz:
https://doaj.org/article/3b194b148b5c46b6a2de2a929170310a
Autor:
François Czarny, Filippo Del Bene, Shahad Albadri, Juliette Vougny, Jean-Paul Concordet, Marina Mione, Marion Rosello
While zebrafish is emerging as a new model system to study human diseases, an efficient methodology to generate precise point mutations at high efficiency is still lacking. Here we show that base editors can generate C-to-T point mutations with high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6aabe452ab2168d28ec3aa27b5618dc8
https://doi.org/10.1101/2020.12.12.422520
https://doi.org/10.1101/2020.12.12.422520
