Zobrazeno 1 - 10
of 259
pro vyhledávání: '"Marina, Botto"'
Autor:
Jack S. Gisby, Norzawani B. Buang, Artemis Papadaki, Candice L. Clarke, Talat H. Malik, Nicholas Medjeral-Thomas, Damiola Pinheiro, Paige M. Mortimer, Shanice Lewis, Eleanor Sandhu, Stephen P. McAdoo, Maria F. Prendecki, Michelle Willicombe, Matthew C. Pickering, Marina Botto, David C. Thomas, James E. Peters
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
End-stage kidney disease confers a high risk for severe COVID-19 infection. Using an at-risk group (end-stage kidney disease patients with COVID-19), authors using RNA-sequencing of immune cells and plasma proteomic profiling to investigate the host
Externí odkaz:
https://doaj.org/article/6195c991b86743c2bc2cea16ffcb650a
Autor:
William D Jackson, Chiara Giacomassi, Sophie Ward, Amber Owen, Tiago C Luis, Sarah Spear, Kevin J Woollard, Cecilia Johansson, Jessica Strid, Marina Botto
Publikováno v:
eLife, Vol 12 (2023)
Monocytes are heterogeneous innate effector leukocytes generated in the bone marrow and released into circulation in a CCR2-dependent manner. During infection or inflammation, myelopoiesis is modulated to rapidly meet the demand for more effector cel
Externí odkaz:
https://doaj.org/article/7cd1a0fcc2d8479483200969f73c2d8f
Autor:
Denise Chan, Phillip R. Bennett, Yun S. Lee, Samit Kundu, T. G. Teoh, Malko Adan, Saqa Ahmed, Richard G. Brown, Anna L. David, Holly V. Lewis, Belen Gimeno-Molina, Jane E. Norman, Sarah J. Stock, Vasso Terzidou, Pascale Kropf, Marina Botto, David A. MacIntyre, Lynne Sykes
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Gaining mechanistic insight into the microbiological and immunological factors that are associated with spontaneous preterm birth is important for the development of prevention strategies. Here authors show that the complement system in conjunction w
Externí odkaz:
https://doaj.org/article/a995c06a0698458d840b5ddd6194cb8a
Autor:
Ian N Bruce, Liz Lightstone, Marina Botto, Alyssa C Gilmore, Hannah R Wilson, Thomas D Cairns, Herbert Terence Cook, Matthew Caleb Pickering
Publikováno v:
Lupus Science and Medicine, Vol 9, Iss 1 (2022)
Objective To explore the utility of the NanoString platform in elucidating kidney immune transcripts for class III, IV and V lupus nephritis (LN) using a retrospective cohort of formalin-fixed paraffin-embedded (FFPE) kidney biopsy tissue.Methods Imm
Externí odkaz:
https://doaj.org/article/36ff49a058a34892bd4a4694aa61666c
Autor:
Andrea Doni, Raffaella Parente, Ilaria Laface, Elena Magrini, Cristina Cunha, Federico Simone Colombo, João F. Lacerda, António Campos, Sarah N. Mapelli, Francesca Petroni, Rémi Porte, Tilo Schorn, Antonio Inforzato, Toine Mercier, Katrien Lagrou, Johan Maertens, John D. Lambris, Barbara Bottazzi, Cecilia Garlanda, Marina Botto, Agostinho Carvalho, Alberto Mantovani
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Serum Amyloid P is a humoral component with established roles in the response to bacterial infection and regulation of tissue remodeling. Here the authors provide evidence to a further crucial role of serum amyloid P in the context of fungal pathogen
Externí odkaz:
https://doaj.org/article/242e6b06db064e1db778527e7d0f6479
Autor:
Neil Solomons, Ian N Bruce, Paul Emery, Caroline Gordon, Edward Vital, David Jayne, David Isenberg, Neil McHugh, Miriam Wittmann, Stephen Young, John Reynolds, Niels Peek, Mark Lunt, Li Su, Sean Gavan, Katherine Payne, Michael Ehrenstein, Vern Farewell, Timothy Vyse, Marina Botto, David Lester Morris, D D’Cruz, Nophar Geifman, Angela Midgley, Matt Truman, Stephen McDonald, Sean Yiu, Laura Lisk, Gillian Armitt, Jennifer Prattley, Narges Azadbakht, Angela Papazian, Helen Le Sueur, Carmen Farrelly, Clare Richardson, Zunnaira Shabbir, Lauren Hewitt, Matthew Pickering, Elizabeth Lightstone, Alyssa Gilmore, Michael Beresford, Christian Hedrich, Jenna Gritzfeld, Mariea Parvaz, Jane Dunnage, Jane Batchelor, E Holland, Pauline Upsall
Publikováno v:
Lupus Science and Medicine, Vol 9, Iss 1 (2022)
Objectives To identify predictors of overall lupus and lupus nephritis (LN) responses in patients with LN.Methods Data from the Aspreva Lupus Management Study (ALMS) trial cohort was used to identify baseline predictors of response at 6 months. Endpo
Externí odkaz:
https://doaj.org/article/e8abdf0db45c48c2bc679943283668a8
Autor:
Norzawani Buang, Lunnathaya Tapeng, Victor Gray, Alessandro Sardini, Chad Whilding, Liz Lightstone, Thomas D. Cairns, Matthew C. Pickering, Jacques Behmoaras, Guang Sheng Ling, Marina Botto
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Lupus pathogenesis is associated with high type 1 interferon stimulated gene (ISG) expression. Here, the authors correlate ISG expression in CD8+ T cells from lupus nephritis patients with abnormal mitochondrial function, implicating increased NAD co
Externí odkaz:
https://doaj.org/article/956b2c52bede4e939180a254c3701f31
Autor:
Beatrice Belmonte, Alessandro Mangogna, Alessandro Gulino, Valeria Cancila, Gaia Morello, Chiara Agostinis, Roberta Bulla, Giuseppe Ricci, Filippo Fraggetta, Marina Botto, Peter Garred, Francesco Tedesco
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Pre-eclampsia is a pregnancy complication characterized by defective vascular remodeling in maternal decidua responsible for reduced blood flow leading to functional and structural alterations in the placenta. We have investigated the contribution of
Externí odkaz:
https://doaj.org/article/16215fd17a2443a4a248f67354a26dad
Autor:
Dominika W. Gajdasik, Fabrina Gaspal, Emily E. Halford, Remi Fiancette, Emma E. Dutton, Claire Willis, Timo Rückert, Chiara Romagnani, Audrey Gerard, Sarah L. Bevington, Andrew S. MacDonald, Marina Botto, Timothy Vyse, David R. Withers
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The OX40-OX40L axis is a crucial component of the costimulatory requirement of CD4 T cell responses. Here, the authors show context and cell type specific expression of OX40L for driving Th1 cell generation during acute and chronic models of infectio
Externí odkaz:
https://doaj.org/article/0ea90bbafd214ffb93f45a5e4c9d3fb6
Autor:
Nicholas R. Medjeral-Thomas, Anne Troldborg, Annette G. Hansen, Jack Gisby, Candice L. Clarke, Maria Prendecki, Stephen P. McAdoo, Eleanor Sandhu, Liz Lightstone, David C. Thomas, Michelle Willicombe, Marina Botto, James E. Peters, Matthew C. Pickering, Steffen Thiel
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
We do not understand why non-white ethnicity and chronic kidney disease increase susceptibility to COVID-19. The lectin pathway of complement activation is a key contributor to innate immunity and inflammation. Concentrations of plasma lectin pathway
Externí odkaz:
https://doaj.org/article/f1fcae5986ee451d9f771a6f71f26323