The H3.3K27M oncohistone affects replication stress outcome and provokes genomic instability in pediatric glioma

Autor: Jonas Seiler, Marin T Mondria, Irena Bockaj, Marcel A. T. M. van Vugt, Bjorn Bakker, Diana C.J. Spierings, Femke Ringnalda, Saskia L Meuleman, Mathilde J.C. Broekhuis, Ulrich Schüller, Floris Foijer, Hans Clevers, Colin Stok, Tosca. E. I. Martini, Eduardo Sabino de Camargo Magalhães, Hilda van den Bos, Yannick P Kok, Tiny G. J. Meeuwsen-de Boer, Inna Armandari, René Wardenaar, Petra L. Bakker, Sophia W.M. Bruggeman

Publikováno v: PLoS Genetics, Vol 17, Iss 11 (2021)
PLoS Genetics, 17(11). Public Library of Science
PLoS genetics, 17(11):1009868. PUBLIC LIBRARY SCIENCE
PLoS Genetics, Vol 17, Iss 11, p e1009868 (2021)
Bočkaj, I, Martini, T E I, de Camargo Magalhães, E S, Bakker, P L, Meeuwsen-de Boer, T G J, Armandari, I, Meuleman, S L, Mondria, M T, Stok, C, Kok, Y P, Bakker, B, Wardenaar, R, Seiler, J, Broekhuis, M J C, van den Bos, H, Spierings, D C J, Ringnalda, F C A, Clevers, H, Schüller, U, van Vugt, M A T M, Foijer, F & Bruggeman, S W M 2021, ' The H3.3K27M oncohistone affects replication stress outcome and provokes genomic instability in pediatric glioma ', PLoS Genetics, vol. 17, no. 11, e1009868, pp. e1009868 . https://doi.org/10.1371/journal.pgen.1009868
PLoS Genetics, 17(11):e1009868. Public Library of Science
PLoS Genetics

While comprehensive molecular profiling of histone H3.3 mutant pediatric high-grade glioma has revealed extensive dysregulation of the chromatin landscape, the exact mechanisms driving tumor formation remain poorly understood. Since H3.3 mutant gliom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d157360aabb1f0585911942661e0904
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604337/?tool=EBI