Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Marin L. Gantner"'
Autor:
Courtney R. Green, Roberto Bonelli, Brendan R.E. Ansell, Simone Tzaridis, Michal K. Handzlik, Grace H. McGregor, Barbara Hart, Jennifer Trombley, Mary M. Reilly, Paul S. Bernstein, Catherine Egan, Marcus Fruttiger, Martina Wallace, Melanie Bahlo, Martin Friedlander, Christian M. Metallo, Marin L. Gantner
Publikováno v:
Molecular Metabolism, Vol 72, Iss , Pp 101716- (2023)
Objectives: The non-essential amino acids serine, glycine, and alanine, as well as diverse sphingolipid species, are implicated in inherited neuro-retinal disorders and are metabolically linked by serine palmitoyltransferase (SPT), a key enzyme in me
Externí odkaz:
https://doaj.org/article/a1141ae99945415d9c14b187d2016bad
Autor:
Kevin T. Eade, Brendan Robert E. Ansell, Sarah Giles, Regis Fallon, Sarah Harkins-Perry, Takayuki Nagasaki, Simone Tzaridis, Martina Wallace, Elizabeth A. Mills, Samaneh Farashi, Alec Johnson, Lydia Sauer, Barbara Hart, M. Elena Diaz-Rubio, Melanie Bahlo, Christian Metallo, Rando Allikmets, Marin L. Gantner, Paul S. Bernstein, Martin Friedlander
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 9 (2023)
Patient-derived induced pluripotent stem cells (iPSCs) provide a powerful tool for identifying cellular and molecular mechanisms of disease. Macular telangiectasia type 2 (MacTel) is a rare, late-onset degenerative retinal disease with an extremely h
Externí odkaz:
https://doaj.org/article/c36953378fea49618ef3b23be50c87cb
Autor:
Erin L. Brown, Bethany C. Hazen, Elodie Eury, Jean-Sébastien Wattez, Marin L. Gantner, Verena Albert, Sarah Chau, Manuel Sanchez-Alavez, Bruno Conti, Anastasia Kralli
Publikováno v:
iScience, Vol 2, Iss , Pp 221-237 (2018)
Summary: Adrenergic stimulation of brown adipose tissue (BAT) induces acute and long-term responses. The acute adrenergic response activates thermogenesis by uncoupling oxidative phosphorylation and enabling increased substrate oxidation. Long-term,
Externí odkaz:
https://doaj.org/article/24d87279e8a148f7a6c2a7388b0e7c79
Autor:
Elizabeth A. Pearsall, Rui Cheng, Kelu Zhou, Yusuke Takahashi, H. Greg Matlock, Shraddha S. Vadvalkar, Younghwa Shin, Thomas W. Fredrick, Marin L. Gantner, Steven Meng, Zhongjie Fu, Yan Gong, Michael Kinter, Kenneth M. Humphries, Luke I. Szweda, Lois E. H. Smith, Jian-xing Ma
Publikováno v:
BMC Biology, Vol 15, Iss 1, Pp 1-14 (2017)
Abstract Background Peroxisome proliferator activated receptor-alpha (PPARα) is a ubiquitously expressed nuclear receptor. The role of endogenous PPARα in retinal neuronal homeostasis is unknown. Retinal photoreceptors are the highest energy-consum
Externí odkaz:
https://doaj.org/article/737e5444751644bb9043deb84110c20b
Autor:
Michal K. Handzlik, Jivani M. Gengatharan, Katie E. Frizzi, Grace H. McGregor, Cameron Martino, Gibraan Rahman, Antonio Gonzalez, Ana M. Moreno, Courtney R. Green, Lucie S. Guernsey, Terry Lin, Patrick Tseng, Yoichiro Ideguchi, Regis J. Fallon, Amandine Chaix, Satchidananda Panda, Prashant Mali, Martina Wallace, Rob Knight, Marin L. Gantner, Nigel A. Calcutt, Christian M. Metallo
Publikováno v:
Nature, vol 614, iss 7946
Diabetes represents a spectrum of disease in which metabolic dysfunction damages multiple organ systems including liver, kidneys and peripheral nerves1,2. Although the onset and progression of these co-morbidities are linked with insulin resistance,
Supplementary Methods and Materials, Figure Legends 1-9 from Estrogen-Related Receptor Gamma Promotes Mesenchymal-to-Epithelial Transition and Suppresses Breast Tumor Growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d4ac34e28b1e144317ce3885ba86877
https://doi.org/10.1158/0008-5472.22386525
https://doi.org/10.1158/0008-5472.22386525
Supplementary Tables 1-3 from Estrogen-Related Receptor Gamma Promotes Mesenchymal-to-Epithelial Transition and Suppresses Breast Tumor Growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cb1c787ac0b9fcae475bc574c8b0378
https://doi.org/10.1158/0008-5472.22386522.v1
https://doi.org/10.1158/0008-5472.22386522.v1
Supplementary Figures 1-9 from Estrogen-Related Receptor Gamma Promotes Mesenchymal-to-Epithelial Transition and Suppresses Breast Tumor Growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b3d8a18807bc8a68d1d5c4fff53b8cb
https://doi.org/10.1158/0008-5472.22386528.v1
https://doi.org/10.1158/0008-5472.22386528.v1
Autor:
Toshihide Kurihara, Peter D Westenskow, Marin L Gantner, Yoshihiko Usui, Andrew Schultz, Stephen Bravo, Edith Aguilar, Carli Wittgrove, Mollie SH Friedlander, Liliana P Paris, Emily Chew, Gary Siuzdak, Martin Friedlander
Publikováno v:
eLife, Vol 5 (2016)
Photoreceptors are the most numerous and metabolically demanding cells in the retina. Their primary nutrient source is the choriocapillaris, and both the choriocapillaris and photoreceptors require trophic and functional support from retinal pigment
Externí odkaz:
https://doaj.org/article/0b14b8790cbf4894836b0a9e30c351ce
Autor:
Marin L. Gantner, Salome Murinello, Edith Aguilar, Peter E. Wright, Martin Friedlander, Mitchell Prins, Rebecca B. Berlow, Ayumi Usui-Ouchi
Publikováno v:
Proc Natl Acad Sci U S A
Retinal neovascularization (NV), a leading cause of vision loss, results from localized hypoxia that stabilizes the hypoxia-inducible transcription factors HIF-1α and HIF-2α, enabling the expression of angiogenic factors and genes required to maint