Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Marim M. Barghash"'
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Proteostasis mechanisms significantly contribute to the sculpting of the proteomes of all living organisms. ClpXP is a central AAA+ chaperone-protease complex present in both prokaryotes and eukaryotes that facilitates the unfolding and subsequent de
Externí odkaz:
https://doaj.org/article/ac7886371b2f446d8ae03246789fdaac
Autor:
Alejandro Ruiz-Riquelme, Alison Mao, Marim M. Barghash, Heather H. C. Lau, Erica Stuart, Gabor G. Kovacs, K. Peter R. Nilsson, Paul E. Fraser, Gerold Schmitt-Ulms, Joel C. Watts
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-19 (2021)
Abstract When injected into genetically modified mice, aggregates of the amyloid-β (Aβ) peptide from the brains of Alzheimer’s disease (AD) patients or transgenic AD mouse models seed cerebral Aβ deposition in a prion-like fashion. Within the br
Externí odkaz:
https://doaj.org/article/311ee78e40194926b8b50a33d61a9ceb
Autor:
Mark F. Mabanglo, Keith S. Wong, Marim M. Barghash, Lee M. Graves, Edwin J. Iwanowicz, Walid A. Houry
Publikováno v:
Cancer Research. 83:3843-3843
The mitochondrial ClpP protease is responsible for mitochondrial protein quality control through specific degradation of proteins involved in several metabolic processes. ClpP overexpression is also required in many cancer cells to eliminate ROS-dama
Autor:
Mark F. Mabanglo, Keith S. Wong, Marim M. Barghash, Elisa Leung, Stephanie H.W. Chuang, Afshan Ardalan, Emily M. Majaesic, Cassandra J. Wong, Shen Zhang, Henk Lang, Donald S. Karanewsky, Andrew A. Iwanowicz, Lee M. Graves, Edwin J. Iwanowicz, Anne-Claude Gingras, Walid A. Houry
Publikováno v:
Structure. 31:185-200.e10
The mitochondrial ClpP protease is responsible for mitochondrial protein quality control through specific degradation of proteins involved in several metabolic processes. ClpP overexpression is also required in many cancer cells to eliminate reactive
Autor:
Walid A. Houry, Boxi Song, Funing Lin, Michele Cossette, Marim M Barghash, Elisa Leung, Emil F. Pai, Scott D. Gray-Owen, Gursonika Binepal, Robert A. Batey, Jazmin Bansagi, Vitor Serrão, Jordan D. Goodreid, Mark F. Mabanglo, Keith S. Wong
Publikováno v:
ACS Infectious Diseases. 6:3224-3236
Evolving antimicrobial resistance has motivated the search for novel targets and alternative therapies. Caseinolytic protease (ClpP) has emerged as an enticing new target since its function is conserved and essential for bacterial fitness, and becaus
Autor:
K. Peter R. Nilsson, Joel C. Watts, Gabor G. Kovacs, Paul E. Fraser, Heather H. C. Lau, Gerold Schmitt-Ulms, Marim M Barghash, Alejandro Ruiz-Riquelme, Erica Stuart, Alison Mao
Publikováno v:
Acta Neuropathologica Communications
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-19 (2021)
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-19 (2021)
When injected into genetically modified mice, aggregates of the amyloid-beta (A beta) peptide from the brains of Alzheimers disease (AD) patients or transgenic AD mouse models seed cerebral A beta deposition in a prion-like fashion. Within the brain,
Autor:
Ruiz-Riquelme, Alejandro, Mao, Alison, Marim M. Barghash, Lau, Heather H. C., Stuart, Erica, Kovacs, Gabor G., K. Peter R. Nilsson, Fraser, Paul E., Schmitt-Ulms, Gerold, Watts, Joel C.
Additional file 1: Supplementary Table 1.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55476e78e0cff26a47a9300cf415996c
Autor:
Gursonika, Binepal, Mark F, Mabanglo, Jordan D, Goodreid, Elisa, Leung, Marim M, Barghash, Keith S, Wong, Funing, Lin, Michele, Cossette, Jazmin, Bansagi, Boxi, Song, Vitor Hugo, Balasco Serrão, Emil F, Pai, Robert A, Batey, Scott D, Gray-Owen, Walid A, Houry
Publikováno v:
ACS Infect Dis
Evolving antimicrobial resistance has motivated the search for novel targets and alternative therapies. Caseinolytic protease (ClpP) has emerged as an enticing new target since its function is conserved and essential for bacterial fitness, and becaus
Autor:
Siavash Vahidi, Elisa Leung, Emil F. Pai, Bryan T. Eger, Sadhna Phanse, Yu-Qian Mao, Vaibhav Bhandari, Mark F. Mabanglo, Jin Lin Zhou, Marim M Barghash, Robert A. Batey, Mohan Babu, Kamran Rizzolo, Thiago V. Seraphim, Steve Bryson, Walid A. Houry, Carlos H.I. Ramos, Lewis E. Kay, Leandro R.S. Barbosa, Jordan D. Goodreid
Publikováno v:
Communications Biology
Communications Biology, Vol 2, Iss 1, Pp 1-14 (2019)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Communications Biology, Vol 2, Iss 1, Pp 1-14 (2019)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Bacterial ClpP is a highly conserved, cylindrical, self-compartmentalizing serine protease required for maintaining cellular proteostasis. Small molecule acyldepsipeptides (ADEPs) and activators of self-compartmentalized proteases 1 (ACP1s) cause dys