Protective activity of (1S,2E,4R,6R,7E,11E)-2,7,11-cembratriene-4,6-diol analogues against diisopropylfluorophosphate neurotoxicity: Preliminary structure–activity relationship and pharmacophore modeling

Autor: Vesna A. Eterovic, Dinely Pérez, Mohammad A. Khanfar, Angelie Del Valle-Rodriguez, Pedro A. Ferchmin, Khalid A. El Sayed, Marimée Carrasco

Publikováno v: Bioorganic & Medicinal Chemistry. 21:4678-4686

Diisopropylfluorophosphate (DFP) is an organophosphorous insecticide used as a surrogate for the more toxic chemical warfare nerve agent sarin. DFP produces neurotoxicity in vivo and irreversibly decreases the area of population spikes recorded from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65ae2bfd944e466f708d8bf8c5c13c56
https://doi.org/10.1016/j.bmc.2013.05.018

4R-cembranoid protects against diisopropylfluorophosphate-mediated neurodegeneration

Autor: Wilmarie Torres-Rivera, Rebeca Reyes Salaman, Jae Eun Lee, Joyce Velez-Roman, Vesna A. Eterovic, Annabell C. Segarra, Myrna Andino, Antonio H. Martins, P.A. Ferchmin, Marimée Carrasco, Brenda L. Cuadrado, Janaina Maria Alves

Many organophosphorous esters synthesized for applications in industry, agriculture, or warfare irreversibly inhibit acetylcholinesterase, and acute poisoning with these compounds causes life-threatening cholinergic overstimulation. Following classic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a07b81eb676b3b4dc89cdd218f413bf4
https://europepmc.org/articles/PMC4176603/

Kinin-B2 receptor mediated neuroprotection after NMDA excitotoxicity is reversed in the presence of Kinin-B1 receptor agonists

Autor: Antonio H. Martins, Henning Ulrich, Pedro A. Ferchmin, Janaina Maria Alves, Dinely Pérez, Marimée Carrasco, Wilmarie Torres-Rivera, Vesna A. Eterovic

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
PLoS ONE
PLoS ONE, Vol 7, Iss 2, p e30755 (2012)

Background Kinins, with bradykinin and des-Arg9-bradykinin being the most important ones, are pro-inflammatory peptides released after tissue injury including stroke. Although the actions of bradykinin are in general well characterized; it remains co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d93c9040c524c33fed6b918a6a915538

Cembranoids structure–activity relationship for protection against diisopropylfluorophosphate damage

Autor: Vesna A. Eterovic, Hassan Y. Ebrahim, P.A. Ferchmin, K.A. El Sayed, Dinely Pérez, Marimée Carrasco

Publikováno v: Biochemical Pharmacology. 97:627

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1fffd49df33385d1455a9082d1591914
https://doi.org/10.1016/j.bcp.2015.08.019

Protective activity of (1S,2E,4R,6R,7E,11E)-2,7,11-cembratriene-4,6-diol analogues against diisopropylfluorophosphate neurotoxicity

Autor: A. Del Valle-Rodrigez, P.A. Ferchmin, Marimée Carrasco, Dinely Pérez, K.A. El Sayed, Vesna A. Eterovic, Mohammad A. Khanfar

Publikováno v: Biochemical Pharmacology. 86:1233

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::520c95a641a955d43366bca93374179c
https://doi.org/10.1016/j.bcp.2013.08.051