Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Marilynn Vetzel"'
Autor:
Joseph A. Reddy, Melissa Nelson, Christina Dircksen, Marilynn Vetzel, Theresa Johnson, Vicky Cross, Elaine Westrick, LongWu Qi, Spencer Hahn, Hari Krishna Santhapuram, Garth Parham, Kevin Wang, Jeremy F. Vaughn, Albert Felten, Michael Pugh, June Lu, Patrick Klein, Iontcho R. Vlahov, Christopher P. Leamon
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Abstract Folate receptor (FR)-targeted small molecule drug conjugates (SMDCs) have shown promising results in early stage clinical trials with microtubule destabilizing agents, such as vintafolide and EC1456. In our effort to develop FR-targeted SMDC
Externí odkaz:
https://doaj.org/article/62cffd133d60412fb62fcc23f334889b
Autor:
Yingjuan J. Lu, Haiyan Chu, Leroy W. Wheeler, Melissa Nelson, Elaine Westrick, James F. Matthaei, Ian I. Cardle, Adam Johnson, Joshua Gustafson, Nikki Parker, Marilynn Vetzel, Le-Cun Xu, Emilia Z. Wang, Michael C. Jensen, Patrick J. Klein, Philip S. Low, Christopher P. Leamon
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Chimeric antigen receptor (CAR)-T cell therapy has transformed pediatric oncology by producing high remission rates and potent effects in CD19+ B-cell malignancies. This scenario is ideal as CD19 expression is homogeneous and human blood provides a f
Externí odkaz:
https://doaj.org/article/25853ddcfde5498d880a46edf8747200
Autor:
Christopher P. Leamon, Isabelle Dussault, Emmett V. Schmidt, Kristen L. Picard, Andrey Loboda, Theresa Zhang, Michael Nebozhyn, Serguei Lejnine, Marilynn Vetzel, Melissa Nelson, Alicia Bloomfield, Ryan Dorton, Marlene C. Hinton, Brian B. Haines, Razvan Cristescu, Joseph A. Reddy, Alexander Stoeck, Jennifer O'Neil, Amy D. Guertin
Supplementary Figure 1: Assessment of kidney cancer cell lines A498, 786-O, and A704 via flow cytometry revealed surface expression of P-gp in all lines; Supplementary Figure 2: 786-O and A704 cells were transduced with lentiviral FR1, and flow cytom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13b3ef96e0e06a8b39939d2f61b13772
https://doi.org/10.1158/1535-7163.22508953
https://doi.org/10.1158/1535-7163.22508953
Autor:
Christopher P. Leamon, Isabelle Dussault, Emmett V. Schmidt, Kristen L. Picard, Andrey Loboda, Theresa Zhang, Michael Nebozhyn, Serguei Lejnine, Marilynn Vetzel, Melissa Nelson, Alicia Bloomfield, Ryan Dorton, Marlene C. Hinton, Brian B. Haines, Razvan Cristescu, Joseph A. Reddy, Alexander Stoeck, Jennifer O'Neil, Amy D. Guertin
Legends for Supplementary Figures 1-4 and Supplementary Tables 1 & 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3039f3b3f096fc558ea35d52fe3d7e9a
https://doi.org/10.1158/1535-7163.22508959
https://doi.org/10.1158/1535-7163.22508959
Autor:
Iontcho Radoslavov Vlahov, Garth L. Parham, Patrick J. Klein, Elaine Westrick, June Lu, Christopher P. Leamon, Christina Dircksen, Marilynn Vetzel, Jeremy F. Vaughn, Albert Felten, Melissa Nelson, Vicky A. Cross, Longwu Qi, Kevin Wang, Hari Krishna Santhapuram, Joseph A. Reddy, Theresa Johnson, Spencer Hahn, Michael Pugh
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
Folate receptor (FR)-targeted small molecule drug conjugates (SMDCs) have shown promising results in early stage clinical trials with microtubule destabilizing agents, such as vintafolide and EC1456. In our effort to develop FR-targeted SMDCs with va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15ed05b6b9a4a1a14ba196fd2dae0bab
https://doi.org/10.1038/s41598-020-69682-9
https://doi.org/10.1038/s41598-020-69682-9
Autor:
Marilynn Vetzel, Hari Krishna Santhapuram, Christina Dircksen, Alicia Bloomfield, Iontcho Radoslavov Vlahov, Paul J. Kleindl, Melissa Nelson, Joseph A. Reddy, Ryan Dorton, Christopher P. Leamon
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
EC1456 is a folate-tubulysin conjugate constructed with an all-D enantiomeric spacer/linker configuration. When tested against folate receptor (FR)-positive cells, EC1456 demonstrated dose-responsive activity with an approximate 1000-fold level of sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ede75dcf036acc8e8a7c9f4805d63d4
http://link.springer.com/article/10.1038/s41598-018-27320-5
http://link.springer.com/article/10.1038/s41598-018-27320-5
Autor:
Jeremy F. Vaughn, Joseph A. Reddy, Hari Krishna Santhapuram, Fei You, Hanna F. Klein, Melissa Nelson, Albert Felten, Longwu Qi, Paul J. Kleindl, Christopher P. Leamon, Iontcho Radoslavov Vlahov, Jeff Nicoson, Spencer Hahn, Marilynn Vetzel, Kevin Wang, Garth L. Parham
Publikováno v:
Bioconjugate Chemistry. 28:2921-2931
Pyrrolobenzodiazepines (PBDs) and their dimers (bis-PBDs) have emerged as some of the most potent chemotherapeutic compounds, and are currently under development as novel payloads in antibody-drug conjugates (ADCs). However, when used as stand-alone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd57ff3b52bd26b3369c3eab77a7d8b3
https://doi.org/10.1021/acs.bioconjchem.7b00476
https://doi.org/10.1021/acs.bioconjchem.7b00476
Autor:
Alicia Bloomfield, Iontcho Radoslavov Vlahov, Melissa Nelson, Christopher P. Leamon, Marilynn Vetzel, Kevin Wang, Paul J. Kleindl, Ryan Dorton, Joseph A. Reddy, Spencer Hahn
Publikováno v:
Bioconjugate chemistry. 30(6)
Prostate-specific membrane antigen (PSMA) is a biomarker that is overexpressed on prostate cancer, and it is also present on the neovasculature within many non-prostate solid tumors. Herein, we report on the construction and biological testing of nov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bf3384bbfb6bfe90350c3188a690c09
https://pubmed.ncbi.nlm.nih.gov/31075200
https://pubmed.ncbi.nlm.nih.gov/31075200
Autor:
Joshua A. Gustafson, Adam Johnson, Patrick J. Klein, Christopher P. Leamon, Ian I. Cardle, Philip S. Low, Melissa Nelson, Nikki Parker, Yingjuan J. Lu, Marilynn Vetzel, Le-Cun Xu, Matthaei James, Elaine Westrick, Leroy W. Wheeler, Emilia Z. Wang, Haiyan Chu, Michael C. Jensen
Publikováno v:
Frontiers in Oncology
Frontiers in Oncology, Vol 9 (2019)
Frontiers in Oncology, Vol 9 (2019)
Chimeric antigen receptor (CAR)-T cell therapy has transformed pediatric oncology by producing high remission rates and potent effects in CD19+ B-cell malignancies. This scenario is ideal as CD19 expression is homogeneous and human blood provides a f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f550c5fe33194fd6fcc376e550b8cce
https://doi.org/10.3389/fonc.2019.00151
https://doi.org/10.3389/fonc.2019.00151
Autor:
Kristen L. Picard, Razvan Cristescu, Jennifer O'Neil, Theresa Zhang, Joseph A. Reddy, Melissa Nelson, Marilynn Vetzel, Amy D. Guertin, Andrey Loboda, Serguei Lejnine, Marlene C. Hinton, Emmett V. Schmidt, Alexander Stoeck, Ryan Dorton, Alicia Bloomfield, Isabelle Dussault, Christopher P. Leamon, Michael Nebozhyn, Brian B. Haines
Publikováno v:
Molecular Cancer Therapeutics. 15:1998-2008
Targeting surface receptors overexpressed on cancer cells is one way to specifically treat cancer versus normal cells. Vintafolide (EC145), which consists of folate linked to a cytotoxic small molecule, desacetylvinblastine hydrazide (DAVLBH), takes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dca15cd5460db1b0e805ee42bb8d4df1
https://doi.org/10.1158/1535-7163.mct-15-0950
https://doi.org/10.1158/1535-7163.mct-15-0950