Glycoprotein 170 Induces Platelet-Activating Factor Receptor Membrane Expression and Confers Tumor Cell Hypersensitivity to NK-Dependent Cell Lysis

Autor: Christina Fleet, Yves Denizot, Jean-François Bourge, Philippe Leboulch, Rob Pawliuk, François Sigaux, Christian Berthou, Eugene Michel, Daniela Geromin, Annie Soulié, Marilyne Sasportes

Publikováno v: Journal of Immunology
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2004, 172 (6), pp.3604-11

Multidrug resistance (MDR) confers resistance to anticancer drugs and reduces therapeutic efficiency. It is often characterized by the expression of the MDR1 gene product P-glycoprotein (or gp170) at the membrane of tumor cells. To further propose a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::270b879b3df53cb7f8ed1eb895e01a5e
https://doi.org/10.4049/jimmunol.172.6.3604

Down-regulation of Human Granzyme B Expression by Glucocorticoids

Autor: Jean-François Bourge, Marilyne Sasportes, Pascale Paul, A. Wargnier, François Sigaux, S Legros-Maida, Clotilde Lafaurie

Publikováno v: Journal of Biological Chemistry. 273:35326-35331

The serine protease granzyme B is an essential component of the granule exocytosis pathway, a major apoptotic mechanism used by cytotoxic T lymphocytes and natural killer cells to induce target cell apoptosis. Granzyme B gene transcription is induced

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9e7e44097dd7f9f2ffe7b1a4115f39cc
https://doi.org/10.1074/jbc.273.52.35326

Granzyme B and perforin can be used as predictive markers of acute rejection in heart transplantation

Autor: Nathalie Vallée, A. Wargnier, Christian Berthou, Nicole Sigaux, J. Guillet, Christophe Benvenuti, Marilyne Sasportes, S Legros-Maida, Annie Soulié

Publikováno v: European Journal of Immunology. 24:229-233

We have investigated perforin and granzyme B expression in graft-infiltrating lymphocytes of patients who underwent heart transplantation. Those proteins are commonly present in the cytoplasmic granules of cytotoxic T lymphocytes and are released upo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00829fa22563b266bdc34ef5e39d8c6c
https://doi.org/10.1002/eji.1830240136

Structure and evolutionary origin of the human granzyme H gene

Autor: Marie-Véronique Clément, Jürg Tschopp, Marilyne Sasportes, Dieter E. Jenne, Patrick Haddad, Danièle Mathieu-Mahul

Publikováno v: International Immunology, vol. 3, no. 1, pp. 57-66

Among the molecules proposed to be involved in cytotoxic T lymphocyte (CTL), natural killer (NK) and lymphokine activated killer (LAK) cell-mediated lysis are the granzymes, a family of serine proteases stored in the cytoplasmic granules of CTLs, NK

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb1375c5c3ad996c22ffb202e0557afb
https://doi.org/10.1093/intimm/3.1.57

Structural organization of the hCTLA-1 gene encoding human granzyme B

Autor: Christian-Jacques Larsen, Olivier Bernard, Marie-Véronique Clément, Laurent Degos, Marilyne Sasportes, Patrick Haddad, Danièle Mathieu-Mahul

Publikováno v: Gene. 87:265-271

Cytotoxic T lymphocytes (CTLs) and natural killer/lymphokine-activated cells produce granzymes, a family of serine esterase proteins located in cytoplasmic granules. These might be involved in different cytotoxic pathways. We report the structural or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8a9aff3bc525e73cab1e4a9c4eaabee
https://doi.org/10.1016/0378-1119(90)90311-e