Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Marilyn Torchia"'
Autor:
Haydn L. Ball, Patrick Tremblay, Hong Zhang, Stephen J. DeArmond, Darlene Groth, Michael A. Baldwin, Fred E. Cohen, Stanley B. Prusiner, Jiri G. Safar, Holger Wille, Kiyotoshi Kaneko, Marilyn Torchia
Publikováno v:
Journal of Molecular Biology. 295:997-1007
The molecular basis of the infectious, inherited and sporadic forms of prion diseases is best explained by a conformationally dimorphic protein that can exist in distinct normal and disease-causing isoforms. We identified a 55-residue peptide of a mu
Publikováno v:
Journal of Neuropathology & Experimental Neurology. 58:1244-1249
The kinetics of PrP(Sc) and insoluble PrP accumulation in the spleens and brains of CD-1 mice were studied. The mice were inoculated intracerebrally with RML prions and euthanized at various times between inoculation and the onset of illness at appro
Autor:
Patrick J. Bosque, Fred E. Cohen, Stephen J. DeArmond, Cornelia Heinrich, Stanley B. Prusiner, Hoang Oanh B Nguyen, David Peretz, Surachai Supattapone, Tamaki Muramoto, Holger Wille, Claus Aagaard, Jiri G. Safar, Michael R. Scott, Marilyn Torchia
Publikováno v:
Cell. 96(6):869-878
A redacted prion protein (PrP) of 106 amino acids with two large deletions was expressed in transgenic (Tg) mice deficient for wild-type (wt) PrP (Prnp0/0) and supported prion propagation. RML prions containing full-length PrP(Sc)produced disease in
Autor:
D Lund, Stanley B. Prusiner, George A. Carlson, Darlene Groth, S Banks, Marilyn Torchia, C Reichert, Stephen J. DeArmond
Publikováno v:
Journal of Virology. 71:2342-2345
Mice homozygous for mutant alleles at the gray tremor (gt) locus develop a marked non-intention tremor beginning at 8 days of age. Most homozygous mice die by 3 months. Homozygotes exhibit intense vacuolation of the central nervous system gray matter
Autor:
Patrick Tremblay, Stephen J. DeArmond, Stanley B. Prusiner, Takeshi Haga, Marilyn Torchia, Glenn C. Telling
Publikováno v:
Genes & Development. 10:1736-1750
Transgenic mice overexpressing approximately eightfold the mouse (Mo) prion protein (PrP) gene carrying the P102L mutation of GSS developed neurodegeneration between 150 and 300 days of age, while controls expressing the wild-type MoPrP-A transgene a
Autor:
Stanley B. Prusiner, John Collinge, Dallas Foster, Karen K. Hsiao, Stephen J. DeArmond, Katie C. L. Sidle, Marilyn Torchia, Michael R. Scott, Glenn C. Telling, Shu Lian Yang
Publikováno v:
Proceedings of the National Academy of Sciences. 91:9936-9940
Transgenic (Tg) mice were constructed that express a chimeric prion protein (PrP) in which a segment of mouse (Mo) PrP was replaced with the corresponding human (Hu) PrP sequence. The chimeric PrP, designated MHu2MPrP, differs from MoPrP by 9 amino a
Autor:
Dallas Foster, Shu Lian Yang, Darlene Groth, Stephen J. DeArmond, Dennis Rapp, Marilyn Torchia, Michael R. Scott, Karen K. Hsiao, Hana Serban, Stanley B. Prusiner
Publikováno v:
Proceedings of the National Academy of Sciences. 91:9126-9130
Two lines of transgenic (Tg) mice expressing high (H) levels of the mutant P101L prion protein (PrP) developed a neurologic illness and central nervous system pathology indistinguishable from experimental murine scrapie; these mice were designated Tg
Autor:
David Westaway, George A. Carlson, Darlene Groth, Shu-Lian Yang, Glenn C. Telling, Christine Ebeling, Stephen J. DeArmond, Stanley B. Prusiner, Marilyn Torchia
Publikováno v:
Proceedings of the National Academy of Sciences. 91:5690-5694
Different prion isolates, often referred to as "strains," present an enigma because considerable evidence argues that prions are devoid of nucleic acid. To investigate prion diversity, we inoculated three "strains" of prions into congenic and transge
Publikováno v:
Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences. 343:363-369
Linkage of the prion protein (PrP) and scrapie incubation time genes in mice provided strong evidence for the central role of PrP in determining susceptibility to prion disorders. Considerable evidence now argues that the prion protein and incubation
Autor:
Shu-Lian Yang, Stephen J. DeArmond, Michael R. Scott, Stanley B. Prusiner, Darlene Groth, Marilyn Torchia, Dallas Foster
Publikováno v:
Cell. 73:979-988
Transgenic mice expressing chimeric prion protein (PrP) genes derived from Syrian hamster (SHa) and mouse (Mo) PrP genes were constructed. One SHa/MoPrP gene, designated MH2M PrP, contains five amino acid substitutions encoded by SHaPrP, while anothe