Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Marilyn S, Diehl"'
Publikováno v:
Environmental and Molecular Mutagenesis. 52:355-362
We previously reported a high concordance of in vitro micronucleus (MNvit) results obtained by flow cytometry to the known cytogenetic activity of ten commercially available compounds mentioned as validation compounds in an early draft of the OECD MN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96d72990e7d5396053bdbcb0eb17497a
https://doi.org/10.1002/em.20631
https://doi.org/10.1002/em.20631
Autor:
Ivan Milicic, Jorge D. Brioni, Deliang Zhou, Gerard B. Fox, Gerard D. Gagne, Ramin Faghih, Angela L. Molesky, Arthur A. Hancock, Kennan C. Marsh, Liping Pan, David G. Witte, Timothy A. Esbenshade, Jill M. Wetter, Kaitlin E. Browman, Michael J. Buckley, Gilbert Diaz, Xiaoqing Deng, Victoria A. Komater, John L. Baranowski, Thomas R. Miller, Marlon D. Cowart, Gregory A. Gfesser, Marilyn S. Diehl, Kathleen M. Krueger, Ellen M. Roberts
Publikováno v:
Biochemical Pharmacology. 73:1243-1255
Three novel heterocyclic benzofurans A-688057 ( 1 ), A-687136 ( 2 ), and A-698418 ( 3 ) were profiled for their in vitro and in vivo properties as a new series of histamine H 3 receptor antagonists. The compounds were all found to have nanomolar pote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fc1120f3945a2a50635d43ffdb23648
https://doi.org/10.1016/j.bcp.2007.02.010
https://doi.org/10.1016/j.bcp.2007.02.010
Autor:
Meiqun Jiang, Stanley Didomenico, Ronald D. Snyder, Karen M. Alexander, Shripad S. Bhagwat, Guo Zhu Zheng, Carol T. Wismer, Haixia Yu, Andrew O. Stewart, Marilyn S. Diehl, Gregory A. Gfesser, Kennan C. Marsh, Erol K. Bayburt, Robin R. Frey, Mark A. Matulenko, Marlon D. Cowart, Jeffery A. McKie, Arthur Gomtsyan, Kathy L. Kohlhaas, Michael F. Jarvis, Elizabeth A. Kowaluk, Joseph P. Mikusa, Steve McGaraughty, Chih-Hung Lee
Publikováno v:
Bioorganic & Medicinal Chemistry. 13:3705-3720
4-Amino-5,7-disubstituted pyridopyrimidines are potent, non-nucleoside inhibitors of adenosine kinase (AK). We recently identified a potent, orally efficacious analog, 4 containing a 7-pyridylmorpholine substituted ring system as the key structural e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f95502834c737e63cdbb31651581d988
https://doi.org/10.1016/j.bmc.2005.03.023
https://doi.org/10.1016/j.bmc.2005.03.023
Autor:
Monique Parenteau, George Bolcsfoldi, Jenness B. Majeska, P. V. Bellier, Ingrid Pontén, Carol R. Tometsko, Shuou Zhao, James P. McNamee, Bas-jan van der Leede, Carol W. Johnson, Kerstin Sandelin, Philippe Vanparys, Stephen D. Dertinger, Amira Pearson, David H. Blakey, Anne H. Illi-Love, Lynnette R. Ferguson, James P. Tarca, Geoffrey M. Hynes, Anthony M. Lynch, Janet Bayley, Philip R. Harbach, Nikki E. Hall, Dorothea K. Torous, Marilyn S. Diehl, Anthony L. Filipunas, Karin Cederbrant
Publikováno v:
Environmental and Molecular Mutagenesis. 45:44-55
An interlaboratory study was performed to validate an anti-CD71/flow cytometry-based technique for enumerating micronucleated reticulocytes (MN-RETs) in mouse peripheral blood. These experiments were designed to address International Workshop on Geno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5029831e1b2563511f4615978f36e65a
https://doi.org/10.1002/em.20081
https://doi.org/10.1002/em.20081
Autor:
Arthur A. Hancock, Thomas R. Miller, Kathleen M. Krueger, Gopala Krishna, Peer B. Jacobson, Marilyn S. Diehl, Ramin Faghih, Wilcox, Eugene N. Bush, John K. Pratt, Timothy A. Esbenshade, Marlon D. Cowart, Phong Nguyen
Publikováno v:
Pharmacology and Toxicology. 95:144-152
A-331440 {4′-[3-(3(R)-(dimethylamino)-pyrrolidin-1-yl)-propoxy]-biphenyl-4-carbonitrile}, a potent and selective antagonist of histamine H3 receptors, yielded positive results in an in vitro micronucleus assay, predictive of genotoxicity in vivo. B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e10c85daf5d315d66c3726c015eca909
https://doi.org/10.1111/j.1742-7843.2004.950307.x
https://doi.org/10.1111/j.1742-7843.2004.950307.x
Publikováno v:
Environmental and Molecular Mutagenesis. 36:72-77
The bacterial reverse mutation assay (Ames test) provides a rapid assessment of the mutagenic potential of chemicals. The assay is widely used in the pharmaceutical industry for early assessment during candidate compound selection and for regulatory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f097126ad8bf6c6d7f26a36e3071390
https://doi.org/10.1002/1098-2280(2000)36:1<72::aid-em10>3.0.co
https://doi.org/10.1002/1098-2280(2000)36:1<72::aid-em10>3.0.co
Autor:
Marilyn S. Diehl, Ronald D. Snyder
Publikováno v:
Mutagenesis. 15:203-205
We have recently reported on the use of a cell-based bleomycin amplification assay for the detection of DNA intercalating agents. In order to further validate this assay, two series of proprietary compounds were evaluated for frameshift mutagenesis i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34aa4a80a2a7f609e9cc5ef29c37c05e
https://doi.org/10.1093/mutage/15.3.203
https://doi.org/10.1093/mutage/15.3.203
Autor:
Marilyn S. Diehl, Svetlana L. Avlasevich, Stephen D. Dertinger, Sarojini Raja, Jeffrey C. Bemis, Paul Sonders, John Nicolette, Steven M. Bryce, Jing Shi
Publikováno v:
Environmental and molecular mutagenesis. 51(3)
A flow cytometric method for analyzing suspension cell cultures for micronucleus content has been previously reported (Avlasevich et al. [2006]: Environ Mol Mutagen 47: 56-66). The experiments described herein were undertaken to evaluate the compatib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe844dbf8048470da42f128a7c5fb7c8
https://pubmed.ncbi.nlm.nih.gov/19950402
https://pubmed.ncbi.nlm.nih.gov/19950402
Autor:
Ronald D. Snyder, Marilyn S. Diehl
Publikováno v:
Drug and chemical toxicology. 28(4)
The effect of hypoxia on micronucleus formation in mice was evaluated using special "shoebox" cages containing a silicone rubber membrane that effectively excludes the replacement of cage oxygen as it is spent by group-housed mice. In five separate t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfc8eae0fbb7c49447c37ebd704c42cb
https://pubmed.ncbi.nlm.nih.gov/16298869
https://pubmed.ncbi.nlm.nih.gov/16298869
Autor:
Dorothea K, Torous, Nikki E, Hall, Anne H, Illi-Love, Marilyn S, Diehl, Karin, Cederbrant, Kerstin, Sandelin, Ingrid, Pontén, George, Bolcsfoldi, Lynnette R, Ferguson, Amira, Pearson, Jenness B, Majeska, James P, Tarca, Geoffrey M, Hynes, Anthony M, Lynch, James P, McNamee, Pascale V, Bellier, Monique, Parenteau, David, Blakey, Janet, Bayley, Bas-Jan M, van der Leede, Philippe, Vanparys, Philip R, Harbach, Shuou, Zhao, Anthony L, Filipunas, Carol W, Johnson, Carol R, Tometsko, Stephen D, Dertinger
Publikováno v:
Environmental and molecular mutagenesis. 45(1)
An interlaboratory study was performed to validate an anti-CD71/flow cytometry-based technique for enumerating micronucleated reticulocytes (MN-RETs) in mouse peripheral blood. These experiments were designed to address International Workshop on Geno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cc024378a97685389dcc7f35f6c1060a
https://pubmed.ncbi.nlm.nih.gov/15605355
https://pubmed.ncbi.nlm.nih.gov/15605355