Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Marilyn R. Kehry"'
Autor:
Sujatha Kumar, Srimoyee Ghosh, Geeta Sharma, Zebin Wang, Marilyn R. Kehry, Margaret H. Marino, Tamlyn Y. Neben, Sharon Lu, Shouqi Luo, Simon Roberts, Sridhar Ramaswamy, Hadi Danaee, David Jenkins
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
Inhibitors of programmed cell death protein 1 (PD-1) and its ligand (PD-L1) have dramatically changed the treatment landscape for patients with cancer. Clinical activity of anti-PD-(L)1 antibodies has resulted in increased median overall survival and
Externí odkaz:
https://doaj.org/article/9da6bd9d6003443393ec5b573b0b1c81
Autor:
Victor Hong, Andres McKenzie, Jianhua Chao, Erin K Harning, Ping Li, Francis Burrows, Jiandong Shi, Rachel Lough, Theodore J. Yun, Marcus F. Boehm, Gerardo Ibanez, Ryan Lamer, Kenneth W Weichert, Christina Boykin, Anthone W. Dunah, Istvan J. Enyedy, Christine Ambrose, Noelito Timple, Ryan Van de Water, Marilyn R. Kehry, Marco A. Biamonte, Joseph Arndt, Jeffrey Thompson, Srinivas Rao Kasibhatla, Cristina M Sandoval, Karen Lundgren, Kevin Hong, Pamela A. Snodgrass-Belt, Sarah A. Bixler
Publikováno v:
Journal of Medicinal Chemistry. 55:7786-7795
Alkyne 40, 5-(2-amino-4-chloro-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-methylpent-4-yn-2-ol (EC144), is a second generation inhibitor of heat shock protein 90 (Hsp90) and is substantially more potent in vitro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11fc27a2a6949bbbf83404c803f06d5a
https://doi.org/10.1021/jm300810x
https://doi.org/10.1021/jm300810x
Autor:
Marijke Niens, David V. Serreze, John P. Driver, Marilyn R. Kehry, Clive Wasserfall, Michael J. Haller, Harold D. Chapman, Robert Dunn, Mark A. Atkinson
Publikováno v:
Diabetes
OBJECTIVE Consistent with studies in NOD mice, early clinical trials addressing whether depletion of B cells by the Rituximab CD20-specific antibody provides an effective means for type 1 diabetes reversal have produced promising results. However, to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba80fec234ab492dd5f9dd2195ab21c3
https://doi.org/10.2337/db11-0705
https://doi.org/10.2337/db11-0705
Autor:
Aftab A. Ansari, Fu-Tong Liu, Ross L. Coppel, Guo Xiang Yang, John C. Cambier, M. Eric Gershwin, Keith D. Lindor, Amy Dhirapong, Robert Dunn, Marilyn R. Kehry, Ana Lleo, Thomas A. Packard, Koichi Tsuneyama
Publikováno v:
Hepatology. 53:527-535
Primary biliary cirrhosis (PBC) is considered a model autoimmune disease due to the clinical homogeneity of patients and the classic hallmark of antimitochondrial antibodies (AMAs). Indeed, the presence of AMAs represents the most highly directed and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f56f7b743f9963328c09648d19a3b93b
https://doi.org/10.1002/hep.24044
https://doi.org/10.1002/hep.24044
Autor:
Marilyn R. Kehry, Troy D. Randall, Miguel E. Moreno-García, Kim Kusser, David J. Rawlings, Guixiu Shi, Shirly Becker-Herman, Kelly L. Hudkins, Melvin I. Simon, Denny Liggitt, Michael Tighe, Robert Dunn, Ann Marshak-Rothstein, Betty Mousseau, Ravi S. Misra, Charles E. Alpers, Frances E. Lund, Thi Sau Migone, Anil Thankappan
Publikováno v:
The Journal of Experimental Medicine
Survival of mature B cells is regulated by B cell receptor and BAFFR-dependent signals. We show that B cells from mice lacking the Gαq subunit of trimeric G proteins (Gnaq−/− mice) have an intrinsic survival advantage over normal B cells, even i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b10f183ff6fa9900d4bf5fd00b4214e
https://doi.org/10.1084/jem.20092735
https://doi.org/10.1084/jem.20092735
Autor:
Michael R. Van Scott, Candace Graff, Elisabeth Mertsching, Howard W. Stallings, Marilyn R. Kehry, Jeremy J. Miles, Ella Negrou
Publikováno v:
Clinical Immunology. 128:340-348
Crosslinking Fc(epsilon)RI and FcgammaRIIB receptors inhibits mast cell and basophil activation, decreasing mediator release. In this study, a fusion protein incorporating human Fcgamma and Fc(epsilon) domains, hGE2, was shown to inhibit degranulatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f0b72b95863b5e642047da75a525a96
https://doi.org/10.1016/j.clim.2008.05.001
https://doi.org/10.1016/j.clim.2008.05.001
Autor:
N. Chai, Andrew S. Klein, Mieko Toyoda, Stanley C. Jordan, Gordon D. Wu, Robert Dunn, Yao He, Marilyn R. Kehry
Publikováno v:
Transplant Immunology. 19:178-186
Background B cell depletion by anti-CD20 antibody is used in desensitization protocols and for treatment of antibody-mediated rejection (AMR). However, little is known about the efficacy and the mechanism(s) of action. Methods A mouse model of HLA se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d4db87b5b739dd34e11e2cf5b531864
https://doi.org/10.1016/j.trim.2008.05.004
https://doi.org/10.1016/j.trim.2008.05.004
Autor:
Samuel Kim, Aaron Blouin, Robert Dunn, Larry R. Kaiser, Marilyn R. Kehry, Steven M. Albelda, Veena Kapoor, Zvi G. Fridlender
Publikováno v:
Journal of Immunotherapy. 31:446-457
The role played by B cells in cancer biology is complex and somewhat controversial. Previous studies using genetically engineered mice suggest that B cells may be immunosuppressive and inhibit tumor rejection. However, the effects of B-cell depletion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bc7f6cdff6f44346e68873bb28d7320
https://doi.org/10.1097/cji.0b013e31816d1d6a
https://doi.org/10.1097/cji.0b013e31816d1d6a
Publikováno v:
The Journal of Immunology. 180:7706-7713
B cells are important for the development of most autoimmune diseases. B cell depletion immunotherapy has emerged as an effective treatment for several human autoimmune diseases, although it is unclear whether B cells are necessary for disease induct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1231fe71697080e1ad97fc5e5e526a6e
https://doi.org/10.4049/jimmunol.180.11.7706
https://doi.org/10.4049/jimmunol.180.11.7706
Autor:
Richard N. Pierson, Agnes M. Azimzadeh, James B. Atkinson, Engin Ozkaynak, George L. Zorn, Steffen Pfeiffer, Geraldine G. Miller, Marilyn R. Kehry, G Wu, Carsten Schröder, Shahrooz S. Kelishadi
Publikováno v:
Transplantation. 81:255-264
Background. CD154 mediates key facets of humoral and cellular immunity to alloantigens, and is tolerogenic to influenza antigens in primates. Barriers to CD154-based tolerance induction for primate cardiac allografts have not previously been defined.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afd6fd9db48242db0521400ae6d0c580
https://doi.org/10.1097/01.tp.0000190099.62847.e6
https://doi.org/10.1097/01.tp.0000190099.62847.e6