Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Marilyn Ngo"'
Autor:
Marilyn Ngo, Albert Gough, Anthony Schwacha, Emily Tsai, Andreas Vogt, Tong Ying Shun, Mark E. Schurdak, Nick Wechter
Publikováno v:
SLAS Discov
Mcm2-7 is the molecular motor of eukaryotic replicative helicase, and the regulation of this complex is a major focus of cellular S-phase regulation. Despite its cellular importance, few small-molecule inhibitors of this complex are known. Based upon
Autor:
Ning Chen, Zhijie Ding, Steffi Oesterreich, Zheqi Li, Mark T. Miedel, Andrew M. Stern, Marilyn Ngo, Shannon Puhalla, Ryan Hessenius, D. Lansing Taylor, Peilu Wang, Shanhang Jia, Amir Bahreini, Daniel M. Zuckerman, Tong Ying Shun, Adrian V. Lee
Publikováno v:
Oncology. 94(3)
Objective: Twenty to fifty percent of estrogen receptor-positive (ER+) metastatic breast cancers express mutations within the ER ligand-binding domain. While most studies focused on the constitutive ER signaling activity commonly engendered by these
Autor:
Lansing Taylor, Mark T. Miedel, Ryan Hessenius, Andrew M. Stern, Shannon Puhalla, Amir Bahreini, Tong Ying Shun, Marilyn Ngo, Steffi Oesterreich, Peilu Wang, Shanhang Jia, Adrian V. Lee, Ning Chen, Zhijie Ding
Publikováno v:
Cancer Research. 77:5871-5871
232,000 new cases of invasive breast cancer will be diagnosed in 2016. 40,300 patients will die primarily from metastatic disease. Mortality results from the ability of cancer to evolve and evade therapy. Estrogen receptor (ER+) breast cancer account