Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Marilyn M. Hinkhouse"'
Autor:
Joseph J. Cullen, Matthew Ough, Justine M. Ritchie, Marilyn M. Hinkhouse, Douglas R. Spitz, Ling Li, Anne Lewis
Publikováno v:
Clinical Cancer Research. 10:4550-4558
Purpose: NAD(P)H:quinone oxidoreductase (NQO1) catalyzes the two-electron reduction of quinones to hydroquinones. This reaction is believed to prevent the one-electron reduction of quinones that would result in redox cycling with generation of supero
Autor:
Christine J. Weydert, Justine M. Ritchie, Marilyn M. Hinkhouse, Joseph J. Cullen, Wenqing Sun, Jingru Liu, Larry W. Oberley
Publikováno v:
Human Gene Therapy. 15:239-250
Pancreatic cancer has low levels of antioxidant enzymes including manganese superoxide dismutase (MnSOD), which converts superoxide radical (O(2)(*-)) into hydrogen peroxide (H(2)O(2)), and glutathione peroxidase (GPx), which converts H(2)O(2) into w
Autor:
Matthew Ough, Marilyn M. Hinkhouse, Larry W. Oberley, Anne Lewis, Joseph J. Cullen, Yuping Zhang, Justine M. Ritchie
Publikováno v:
Free Radical Research. 38:1223-1233
Manganese superoxide dismutase (MnSOD) levels have been found to be low in human pancreatic cancer [Pancreas 26, (2003), 23] and human pancreatic cancer cell lines [Cancer Res. 63, (2003), 1297] when compared to normal human pancreas. We hypothesized
Publikováno v:
Journal of Surgical Research. 105:102-108
Background. Coffee consumption decreases the risk of gallstone disease. The proposed motility effects of caffeine, a phosphodiesterase (PDE) inhibitor, are unknown. The aim of our study was to determine the effect of caffeine and specific PDE inhibit
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 81:65-68
Purpose : This investigation examined mRNA expression and enzymatic activity of steroid sulfatase (STS) in human mammary myoepithelial cells (MMECs) and MCF-7 cells and assessed the effects of 17-β estradiol on the activity of STS. Methods : The mRN
Autor:
Kimberly S. Ephgrave, David W. Mercer, Jeffrey L. Conklin, Marilyn M. Hinkhouse, Joseph J. Cullen
Publikováno v:
Surgery. 125:339-344
Background: The disrupted intestinal transit during endotoxemia may be mediated by nitric oxide (NO). We hypothesized that the isoforms of nitric oxide synthase (NOS) are up-regulated in intestinal smooth muscle during endotoxemia and that the scaven
Autor:
Joseph J. Cullen, Marilyn M. Hinkhouse, Robert C. Doty, Kimberly A. Broadhurst, Kimberly S. Ephgrave
Publikováno v:
Journal of Surgical Research. 81:81-86
Background. Septic patients are often intolerant of enteral feedings due to a combination of motility disturbances and impaired absorptive function. Our laboratory has previously demonstrated that endotoxemia results in rapid intestinal transit and d
Publikováno v:
Digestive Diseases and Sciences. 44:2172-2177
The aims of our study were to determinemechanisms by which pancreatobiliary secretion isaltered during endotoxemia. Dogs underwent placement ofduodenal perfusion and aspiration catheters and antralmanometry catheters. Gastric emptying of liquids, ant
Autor:
Birol Yamak, C. Panagopoulos, Hiromi Wada, Vibeke Videm, Ansgar O. Aasen, Toru Bando, Jan-Ludvig Svennevig, D. Kazantzidou, I. Evangelou, Joseph J. Cullen, Lynda L. Hemann, Zafer Işcan, I. Spiliopoulou, T. Scholz, M. Baba, Johannes M. Albes, H. Karlsen, Murat Bayazit, C. Kusano, Marilyn M. Hinkhouse, P. Mylonas, I. Dadoukis, Kimberly S. Ephgrave, Cevat Can, A. Foerster, Theodore K. Alexandrides, Arnt E. Fiane, Hans-Joachim Schäfers, T. Nüsse, Thorsten Wahlers, John Spiliotis, Shigeki Hitomi, K. Shirao, T. Kamada, D. Kardamakis, K. Galovatsea, Tom Eirik Mollnes, A. Shafik, S. Fehmi Katircioglu, Takashi Aikou, Odd Geiran, Thomas Zaraboukas, Ioannis Kanellos, Zülfikar Saritaş, Maria Melachrinou, A. Tulga Ulus, T.H. Perdersen, Jeffrey L. Conklin, Fotios Kalfarentzos, Souji Sane
Publikováno v:
European Surgical Research. 30:359-369
Publikováno v:
Journal of Surgical Research. 74:34-38
Diarrhea is a common manifestation of sepsis. We hypothesized that endotoxin may impair colonic absorption of water and electrolytes, an effect which may be related to altered liquid transit in the colon. Five dogs underwent construction of 50-cm col