Organic Anion Transporter Polypeptide 1B1 Polymorphism Modulates the Extent of Drug–Drug Interaction and Associated Biomarker Levels in Healthy Volunteers

Autor: Sook Wah Yee, Marilyn M. Giacomini, Hong Shen, W. Griffith Humphreys, Howard Horng, William Brian, Yurong Lai, Deanna L. Kroetz, Kathleen M. Giacomini

Publikováno v: Clinical and Translational Science, Vol 12, Iss 4, Pp 388-399 (2019)

Understanding transporter‐mediated drug–drug interactions is an integral part of risk assessment in drug development. Recent studies support the use of hexadecanedioate (HDA), tetradecanedioate (TDA), coproporphyrin (CP)‐I, and CP‐III as clin

Externí odkaz: https://doaj.org/article/7aec9e736d274c7e909b1eb4fcb6398c

Metformin Is a Substrate and Inhibitor of the Human Thiamine Transporter, THTR-2 (SLC19A3)

Autor: Marilyn M. Giacomini, Xiaomin Liang, Huan-Chieh Chien, Meiling Piao, Jia Hao, Jolyn Twelves, Kathleen M. Giacomini, Eugene C. Chen, Sook Wah Yee, Eve-Irene Lepist, Adrian S. Ray

Publikováno v: Molecular Pharmaceutics. 12:4301-4310

The biguanide metformin is widely used as first-line therapy for the treatment of type 2 diabetes. Predominately a cation at physiological pH's, metformin is transported by membrane transporters, which play major roles in its absorption and dispositi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bec0fa35f3b2922a8f751a6b23021bd2
https://doi.org/10.1021/acs.molpharmaceut.5b00501

Metabolomic and Genome-wide Association Studies Reveal Potential Endogenous Biomarkers for OATP1B1

Autor: William Brian, Xiaomin Liang, Kathleen M. Giacomini, Dietmar Weitz, Jason M. Kinchen, Katharina Mertsch, Marilyn M. Giacomini, Deanna L. Kroetz, Srijib Goswami, Arik A. Zur, Sook Wah Yee, Annabelle Coelho, Chia Hsiang Hsueh

Publikováno v: Clinical pharmacology and therapeutics, vol 100, iss 5

Transporter-mediated drug-drug interactions (DDIs) are a major cause of drug toxicities. Using published genome-wide association studies (GWAS) of the human metabolome, we identified 20 metabolites associated with genetic variants in organic anion tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f9411301f318dfaac43ff4b9eb346e7
https://escholarship.org/uc/item/6qx1n0sb

Targeting of alpha(v) integrin identifies a core molecular pathway that regulates fibrosis in several organs

Autor: Jacquelyn J. Maher, Ralf H. Adams, John P. Iredale, Juan D Rodriguez, Yoshio Katamura, Adam Lacy-Hulbert, Antonella Pellicoro, Joseph H. McCarty, David W. Griggs, Christer Betsholtz, Michael J. Prinsen, Marilyn M. Giacomini, Dean Sheppard, Peter G. Ruminski, Elisabeth Raschperger, Thomas D. Arnold, Neil C. Henderson

Publikováno v: Henderson, N C, Arnold, T D, Katamura, Y, Giacomini, M M, Rodriguez, J D, McCarty, J H, Pellicoro, A, Raschperger, E, Betsholtz, C, Ruminski, P G, Griggs, D W, Prinsen, M J, Maher, J J, Iredale, J P, Lacy-Hulbert, A, Adams, R H & Sheppard, D 2013, ' Targeting of alpha(v) integrin identifies a core molecular pathway that regulates fibrosis in several organs ', Nature Medicine, vol. 19, no. 12, pp. 1617-1624 . https://doi.org/10.1038/nm.3282

Myofibroblasts are the major source of extracellular matrix components that accumulate during tissue fibrosis, and hepatic stellate cells (HSCs) are believed to be the major source of myofibroblasts in the liver. To date, robust systems to geneticall

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a1a321a7d0e0af16bde2f284b577503
https://hdl.handle.net/20.500.11820/58156f35-f914-4685-845f-718ef60dfa6e

Breakpoint Analysis of Transcriptional and Genomic Profiles Uncovers Novel Gene Fusions Spanning Multiple Human Cancer Types

Autor: Shirley Zhu, Kelli Montgomery, Jay Michael S. Balagtas, Robert T. Sweeney, Andrew D. Forster, Craig P. Giacomini, Matt van de Rijn, Sushama Varma, A. Hunter Shain, Marilyn M. Giacomini, Everett Lai, Jonathan R. Pollack, Nicole Clarke, Robert B. West, Albert J. Wong, Catherine A. Del Vecchio, Steven Sun

Publikováno v: PLoS Genetics
PLoS Genetics, Vol 9, Iss 4, p e1003464 (2013)

Gene fusions, like BCR/ABL1 in chronic myelogenous leukemia, have long been recognized in hematologic and mesenchymal malignancies. The recent finding of gene fusions in prostate and lung cancers has motivated the search for pathogenic gene fusions i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ad1e5d1c7c756adde76345ac3f9ca5a
http://europepmc.org/articles/PMC3636093