Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Marilyn J. Ramsey"'
Autor:
Marilyn J. Ramsey, Barbara Grajewski, Elizabeth Ward, Elizabeth A. Whelan, Mark P. Little, Lee C. Yong, Parveen Bhatti, Stephen J. Bertke, Martha A. Waters, James D. Tucker, Alice J. Sigurdson
Publikováno v:
Aerospace medicine and human performance. 89(7)
BACKGROUND Chromosome translocations are a biomarker of cumulative exposure to ionizing radiation. We examined the relation between the frequency of translocations and cosmic radiation dose in 83 male airline pilots. METHODS Translocations were score
Autor:
Martin R. Petersen, Marilyn J. Ramsey, Lee C. Yong, Elizabeth A. Whelan, Alice J. Sigurdson, Elaine Ron, Parveen Bhatti, Elizabeth Ward, James D. Tucker, Martha A. Waters
Publikováno v:
Occupational and Environmental Medicine. 66:56-62
Background: Translocations, the most stable form of chromosome aberrations, are an established biomarker of cumulative exposure to external ionizing radiation. Airline pilots are exposed to varying levels of cosmic ionizing radiation, but to date, th
Publikováno v:
Environmental and Molecular Mutagenesis. 45:249-257
Chromosome breaks and rearrangements resulting from ionizing radiation can be much more complicated than many investigators thought possible some years ago. The realization that not all translocations are reciprocal, that multiway exchanges occur, an
Publikováno v:
Radiation Research. 161:648-655
Space exploration has the potential to yield exciting and significant discoveries, but it also brings with it many risks for flight crews. Among the less well studied of these are health effects from space radiation, which includes the highly charged
The relationship between genotype and chromosome aberration frequencies in a normal adult population
Publikováno v:
Pharmacogenetics. 10:311-319
Cancer susceptibility differences may be attributed in part to genetic variation in genes involved in metabolism of environmental procarcinogens. Increased risks for some cancers have been linked to polymorphisms in certain phase I and II genes, and
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 465:101-111
Maternal exposures may induce chromosome damage and birth defects in the fetus. Polymorphic variation in genes coding for enzymes involved in metabolic activation and detoxification of environmental procarcinogens may account for some of the differen
Autor:
T. Ohta, Robert D. Nicholls, Y. Ji, Richard Longnecker, Mark Merchant, James D. Tucker, J. M. Gabriel, Robert G. Caldwell, Marilyn J. Ramsey
Publikováno v:
Proceedings of the National Academy of Sciences. 96:9258-9263
Prader-Willi syndrome (PWS) and Angelman syndrome (AS) result from the loss of function of imprinted genes in human chromosome 15q11–q13. The central part of mouse chromosome 7 is homologous to human 15q11–q13, with conservation of both gene orde
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 425:135-141
In this paper, we present data on chromosome aberration frequencies in mice which served as unexposed controls in a variety of radiation and chemical toxicology experiments conducted in our laboratory in recent years. All chromosome aberration data w
Publikováno v:
Environmental and Molecular Mutagenesis. 32:139-147
Environmental exposure to mutagens is believed to play a significant role in human carcinogenesis. Determination of the in vivo effects of a single mutagen is best done in laboratory animals because humans are exposed to a variety of mutagens both in
Autor:
Jami R. Senft, Marilyn J. Ramsey, James D. Tucker, D. A. Lee, Dan H. Moore, J.F. Briner, Letha A. Olsen
Publikováno v:
Mutation Research/DNAging. 338:95-106
Individual responses to the aging process are variable and are affected by genetic as well as environmental factors. Fluorescent in situ hybridization with whole chromosome probes (‘chromosome painting’) provides an efficient approach for detecti