Výsledky vyhledávání - "Marilyn J. Hewish"

Growth of Rotaviruses in Primary Pancreatic Cells

Autor: Leonard C. Harrison, Yan Tan, Paul D. Witterick, Margo C. Honeyman, Joanne N. Mountford, Barbara S. Coulson, Marilyn J. Hewish

Publikováno v: Journal of Virology. 76:9537-9544

Rotavirus infection in children at risk of developing type 1 diabetes has been temporally associated with development of pancreatic islet autoantibodies. In this study, nonobese diabetic mice were shown to be susceptible to rhesus rotavirus infection

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::238b9aa730720d103dcf5a602885be09
https://doi.org/10.1128/jvi.76.18.9537-9544.2002

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Growth of rotaviruses in continuous human and monkey cell lines that vary in their expression of integrins

Autor: Barbara S. Coulson, Melanie J. Thomson, Georgina M. Sanders, Marilyn J. Hewish, Huseyin Mustafa, Sarah L. Londrigan

Publikováno v: Journal of General Virology. 81:2203-2213

Rotavirus replication occurs in vivo in intestinal epithelial cells. Cell lines fully permissive to rotavirus include kidney epithelial (MA104), colonic (Caco-2) and hepatic (HepG2) types. Previously, it has been shown that cellular integrins alpha 2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::332b172764782b2c10594b0e3ae0c104
https://doi.org/10.1099/0022-1317-81-9-2203

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Integrins α2β1 and α4β1 Can Mediate SA11 Rotavirus Attachment and Entry into Cells

Autor: Marilyn J. Hewish, Yoshikazu Takada, Barbara S. Coulson

Publikováno v: Journal of Virology. 74:228-236

Most mammalian rotaviruses contain tripeptide amino acid sequences in outer capsid proteins VP4 and VP7 which have been shown to act as ligands for integrins α2β1 and α4β1. Peptides containing these sequences and monoclonal antibodies directed to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3fd2ae9e4fb50a87ea50c7527f8e1f79
https://doi.org/10.1128/jvi.74.1.228-236.2000

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HIV Infection of monocyte-derived macrophages in vitro reduces phagocytosis of Candida albicans

Autor: Suzanne M. Crowe, Nicholas J. Vardaxis, Marilyn J. Hewish, Stephen J. Kent, Anne L. Maerz, Michael S. McGrath, John Mills

Publikováno v: Journal of Leukocyte Biology. 56:318-327

HIV-1 infection of peripheral blood monocyte-derived macrophages (MDMs) is unrelated to the level of CD4 expression on the surface of the cell, is associated with considerable donor variability, causes minimal cytopathology, and results in peak viral

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da4dd022254bcb55b6f39c02ad89c88e
https://doi.org/10.1002/jlb.56.3.318

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Rotaviruses interact with alpha4beta7 and alpha4beta1 integrins by binding the same integrin domains as natural ligands

Autor: Kate L, Graham, Fiona E, Fleming, Peter, Halasz, Marilyn J, Hewish, Hadya S, Nagesha, Ian H, Holmes, Yoshikazu, Takada, Barbara S, Coulson

Publikováno v: The Journal of general virology. 86(Pt 12)

Group A rotaviruses are major intestinal pathogens that express potential alpha4beta1 and alpha4beta7 integrin ligand sequences Leu-Asp-Val and Leu-Asp-Ile in their outer capsid protein VP7, and Ile-Asp-Ala in their spike protein VP4. Monkey rotaviru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::499d0dbc1d959d6164c563584676d504
https://pubmed.ncbi.nlm.nih.gov/16298987

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Interferon-gamma therapy activates human monocytes for enhanced phagocytosis of Mycobacterium avium complex in HIV-infected individuals

Autor: Amanda J. Handley, Geza Paukovics, Marilyn J. Hewish, Katarzyna Kedzierska, Jane S Hocking, Suzanne M. Crowe, Paul U. Cameron

Publikováno v: HIV clinical trials. 5(2)

Defective immunological function of cells of the macrophage lineage contributes to the pathogenesis of HIV-1 infection. Because monocyte/macrophage function is enhanced by cytokines such as interferon-gamma (IFN-gamma), the use of this immunomodulato

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::349147efe2a4e76da378b3cf376d8f30
https://pubmed.ncbi.nlm.nih.gov/15116283

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Integrin-using rotaviruses bind alpha2beta1 integrin alpha2 I domain via VP4 DGE sequence and recognize alphaXbeta2 and alphaVbeta3 by using VP7 during cell entry

Autor: Kate L, Graham, Peter, Halasz, Yan, Tan, Marilyn J, Hewish, Yoshikazu, Takada, Erich R, Mackow, Martyn K, Robinson, Barbara S, Coulson

Publikováno v: Journal of virology. 77(18)

Integrins alpha2beta1, alphaXbeta2, and alphaVbeta3 have been implicated in rotavirus cell attachment and entry. The virus spike protein VP4 contains the alpha2beta1 ligand sequence DGE at amino acid positions 308 to 310, and the outer capsid protein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::769c7fded9e352648613bc1c9b8b3a32
https://pubmed.ncbi.nlm.nih.gov/12941907

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Phorbol dibutyrate-induced megakaryocytic differentiation increases susceptibility of K562 cells to SA11 rotavirus infection

Autor: Marilyn J. Hewish, G. M. Sanders, Barbara S. Coulson

Publikováno v: Archives of virology. 146(9)

The role of integrins previously implicated as rotavirus receptors in determining cellular susceptibility to SA11 rotavirus was studied, using phorbol dibutyrate (PDB) treatment of K562 cells to induce megakaryocytic differentiation. Expression of al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b075d464e9a0fe11cd1ea3ad772d04c
https://pubmed.ncbi.nlm.nih.gov/11699968

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