The tumor necrosis factor alpha-induced protein 3 (TNFAIP3, A20) imposes a brake on antitumor activity of CD8 T cells

Autor: Nathalie Auphan-Anezin, Grégory Verdeil, Marilyn Giordano, Anne-Marie Schmitt-Verhulst, Geert van Loo, Rudi Beyaert, Michel Buferne, Lionel Chasson, Romain Roncagalli, Sho Yamasaki, Pierre Bourdely

Publikováno v: Proceedings of the National Academy of Sciences. 111:11115-11120

The transcription factor NF-κB is central to inflammatory signaling and activation of innate and adaptive immune responses. Activation of the NF-κB pathway is tightly controlled by several negative feedback mechanisms, including A20, an ubiquitin-m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3a705b9ee3c529ee97a7df210e8c14c
https://doi.org/10.1073/pnas.1406259111

The PTK7 and ROR2 Protein Receptors Interact in the Vertebrate WNT/Planar Cell Polarity (PCP) Pathway *

Autor: Virginie Thomé, Anne-Catherine Lhoumeau, Laurent Kodjabachian, Sébastien Martinez, Pierluigi Scerbo, Avais M. Daulat, Jean-Paul Borg, Marilyn Giordano

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2015, 290 (51), pp.30562-30572. ⟨10.1074/jbc.M115.697615⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2015, 290 (51), pp.30562-72. ⟨10.1074/jbc.M115.697615⟩
The Journal of Biological Chemistry
Journal of Biological Chemistry, 2015, 290 (51), pp.30562-30572. ⟨10.1074/jbc.M115.697615⟩

Background: The planar cell polarity pathway plays important roles in morphogenetic processes. Results: PTK7 and ROR2 form a heterodimeric complex and bind to WNT5A, promoting JNK phosphorylation and regulating expression of paraxial protocadherin. C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07ec7db2813ce4a0ab1d1c2f1a212282
https://hal.archives-ouvertes.fr/hal-01306990

Molecular profiling of CD8 T cells in autochthonous melanoma identifies Maf as driver of exhaustion

Autor: Marilyn Giordano, Coralie Henin, Julien Maurizio, Claire Imbratta, Pierre Bourdely, Michel Buferne, Lukas Baitsch, Laurent Vanhille, Michael H Sieweke, Daniel E Speiser, Nathalie Auphan‐Anezin, Anne‐Marie Schmitt‐Verhulst, Grégory Verdeil

Publikováno v: The EMBO journal

T cells infiltrating neoplasms express surface molecules typical of chronically virus-stimulated T cells, often termed "exhausted" T cells. We compared the transcriptome of "exhausted" CD8 T cells infiltrating autochthonous melanomas to those of naï

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4473b82cb0f4d07272ed96845b3a883
https://europepmc.org/articles/PMC4551351/

Molecular profiling of CD8 T cells from autochthonous melanoma identifies Maf as driver of T cell exhaustion (TUM2P.1004)

Autor: Gregory Verdeil, Marilyn Giordano, Coralie Henin, Julien Maurizio, Pierre Bourdely, Michel Buferne, Nathalie Auphan-Anezin, Daniel Speiser, A Schmitt-Verhulst

Publikováno v: The Journal of Immunology. 194:69.1-69.1

T-cells infiltrating neoplasms express surface molecules typical of chronically virus-stimulated T-cells, often termed “exhausted” T-cells. We analyzed the transcriptome of “exhausted” CD8 T-cells infiltrating autochthonous melanomas compared

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4a556f8af18a25110684a1381b717943
https://doi.org/10.4049/jimmunol.194.supp.69.1