ECVAM prevalidation of three cell transformation assays

Autor: Laura Gribaldo, Raffaella Corvi, Philippe Vanparys, Sebastian Hoffmann, Makoto Hayashi, Marilyn Aardema, Leonard M. Schechtman

Publikováno v: ALTEX. 28(1)

A prevalidation study on the cell transformation assays in SHE cells at pH 6.7, SHE cells at pH 7.0 and Balb/c 3T3 cell line was coordinated by ECVAM focussing on issues of standardisation of protocols, within-laboratory reproducibility, test method

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9b2885dff95fb61c5531d51d97dedc9
https://pubmed.ncbi.nlm.nih.gov/21311851

Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens II. Further analysis of mammalian cell results, relative predictivity and tumour profiles

Autor: David, Kirkland, Marilyn, Aardema, Lutz, Müller, Hayashi, Makoto

Publikováno v: Mutation research. 608(1)

One of the consequences of the low specificity of the in vitro mammalian cell genotoxicity assays reported in our previous paper [D. Kirkland, M. Aardema, L. Henderson, L. Muller, Evaluation of the ability of a battery of three in vitro genotoxicity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a5fc11fa5d9a79e283a7e3a40295c6e9
https://pubmed.ncbi.nlm.nih.gov/16769241

Genotoxicty and mutagenicity

Autor: Daniela, Maurici, Marilyn, Aardema, Raffaella, Corvi, Marcus, Kleber, Cyrille, Krul, Christian, Laurent, Nicola, Loprieno, Markku, Pasanen, Stefan, Pfuhler, Barry, Phillips, Enrico, Sabbioni, Tore, Sanner, Phillipe, Vanparys

Publikováno v: Alternatives to laboratory animals : ATLA. 33

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8cb1873c757e4e7647444c27212a0ce0
https://pubmed.ncbi.nlm.nih.gov/16194145

Modified Mutagen Metabolism inSchistosoma hematobium–Infested Organisms

Autor: Harvey D. Blankespoor, Marilyn Aardema, James M. Gentile, Debra Clark, Sherri Brown

Publikováno v: Archives of Environmental Health: An International Journal. 40:5-12

The relationship between parasite infestation and chemical mutagen metabolism was investigated in this study. Schistosoma hematobium, long associated with increased incidence of bladder cancer in humans, was chosen as a model parasite. Urine samples,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2ab2569de12a41add9884c1f1ff385a
https://doi.org/10.1080/00039896.1985.10545881

A weight of evidence review of the genotoxicity of titanium dioxide (TiO 2 ).

Autor: Kirkland D; Kirkland Consulting, PO Box 79, Tadcaster LS24 0AS, UK., Aardema MJ; Marilyn Aardema Consulting LLC, 5315 Oakbrook Dr, Fairfield, OH, 45014, USA., Battersby RV; EBRC Consulting GmbH, Kirchhorster Str. 27, 30659, Hannover, Germany., Beevers C; Broughton, Earby, Lancashire, BB18 6JZ, UK., Burnett K; Independent Consultant, Stroud, UK., Burzlaff A; EBRC Consulting GmbH, Kirchhorster Str. 27, 30659, Hannover, Germany., Czich A; Sanofi R&D, 65926, Frankfurt, Germany., Donner EM; Maria Donner Consulting, LLC, Hockessin, DE, 19707, USA., Fowler P; FSTox Consulting Ltd., Northamptonshire, UK. Electronic address: paul.fowler@fstoxconsulting.com., Johnston HJ; Nano Safety Research Group, School of Engineering and Physical Sciences, Heriot Watt University, Edinburgh, EH14 4AS, UK., Krug HF; NanoCASE GmbH, Engelburg, Switzerland., Pfuhler S; Global Product Stewardship, Procter & Gamble, Mason, OH, 45040, USA., Stankowski LF Jr; Charles River Laboratories, Skokie, IL, 60077, USA.

Publikováno v: Regulatory toxicology and pharmacology : RTP [Regul Toxicol Pharmacol] 2022 Dec; Vol. 136, pp. 105263. Date of Electronic Publication: 2022 Oct 11.