An essential Trypanosoma brucei protein kinase: a functional analysis of regulation and the identification of inhibitors

Autor: Marilyn Parsons, Ben Parsons, Marissa Dean, Amy E. DeRocher, Zeba Islam, Dustin J. Maly, Bryan C. Jensen

Publikováno v: Frontiers in Parasitology, Vol 2 (2023)

IntroductionThe protein serine/threonine kinase AEK1 is essential in the pathogenic stage of Trypanosoma brucei, the causative agent of African trypanosomiasis. AEK1 is a member of the AGC protein kinase family, although it is not closely related to

Externí odkaz: https://doaj.org/article/1c8adc61c088481b82cf4080d8a8f6a2

Unusual features and localization of the membrane kinome of Trypanosoma brucei

Autor: Bryan C. Jensen, Pashmi Vaney, John Flaspohler, Isabelle Coppens, Marilyn Parsons

Publikováno v: PLoS ONE, Vol 16, Iss 10 (2021)

In many eukaryotes, multiple protein kinases are situated in the plasma membrane where they respond to extracellular ligands. Ligand binding elicits a signal that is transmitted across the membrane, leading to activation of the cytosolic kinase domai

Externí odkaz: https://doaj.org/article/3341992957bb48d69731747e5d130fb6

Vesicles bearing Toxoplasma apicoplast membrane proteins persist following loss of the relict plastid or Golgi body disruption.

Autor: Anne Bouchut, Jennifer A Geiger, Amy E DeRocher, Marilyn Parsons

Publikováno v: PLoS ONE, Vol 9, Iss 11, p e112096 (2014)

Toxoplasma gondii and malaria parasites contain a unique and essential relict plastid called the apicoplast. Most apicoplast proteins are encoded in the nucleus and are transported to the organelle via the endoplasmic reticulum (ER). Three traffickin

Externí odkaz: https://doaj.org/article/a5ca23e6d0e04b4ea14e69496f6fb54c

Unusual Features of the Membrane Kinome ofTrypanosoma brucei

Autor: Isabelle Coppens, John Flaspohler, Marilyn Parsons, Bryan C. Jensen, Pashmi Vaney

In many eukaryotes, multiple protein kinases are situated in the plasma membrane where they respond to extracellular ligands. Ligand binding elicits a signal that is transmitted across the membrane, leading to activation of the cytosolic kinase domai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ae3a79d41096899bbb75ad53a1f0b574
https://doi.org/10.1101/2020.12.08.416529

List of contributors

Autor: Michael S. Behnke, Sébastien Besteiro, Oliver Billker, Nicolas Blanchard, John C. Boothroyd, Cyrille Botté, Kenneth M. Boyer, Jon P. Boyle, Kevin M. Brown, David J. Bzik, Vern B. Carruthers, Marie-France Cesbron-Delauw, William Cohen, Isabelle Coppens, Marie-Laure Dardé, Alejandra de-la-Torre, Samantha Dovgin, J.P. Dubey, Jean-François Dubremetz, Jean E. Feagin, David J.P. Ferguson, Lauren Finkelstein, Barbara A. Fox, Jorge Enrique Gomez-Marin, Michael E. Grigg, Uwe Groß, Marc-Jan Gubbels, Mohamed-Ali Hakimi, Omar S. Harb, Tajie H. Harris, Christopher A. Hunter, Damien Jacot, Victoria Jeffers, Asis Khan, Kami Kim, Jessica C. Kissinger, Christen M. Klinger, Joachim Kloehn, Laura J. Knoll, Anita A. Koshy, Aarti Krishnan, Maryse Lebrun, David S. Lindsay, Melissa B. Lodoen, Sebastian Lourido, Carsten G.K. Lüder, Malcolm J. McConville, Rima McLeod, Markus Meissner, Aurélien Mercier, Dana G. Mordue, Silvia N.J. Moreno, Naomi Morrissette, Douglas A. Pace, Marilyn Parsons, Utz Reichard, Craig W. Roberts, Ellen A. Robey, David S. Roos, Jeroen P.J. Saeij, Anna Salvioni, Frank Seeber, Lilach Sheiner, L. David Sibley, Anthony P. Sinai, Dominique Soldati-Favre, Boris Striepen, Chunlei Su, William J. Sullivan, Christopher J. Tonkin, Giel G. van Dooren, Jonathan Wastling, Louis M. Weiss, Stuart Woods

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::265c5ef88242df954e8b4d5c6a77919c
https://doi.org/10.1016/b978-0-12-815041-2.00034-7