Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Marilyn, Ferrari"'
Autor:
Martha Sedegah, Glenna Banania, Thomas L. Richie, Maria Belmonte, Arnel Belmonte, Marilyn Ferrari, Noelle B. Patterson, William O. Rogers, Denis Rusalov, Denise L. Doolan
Publikováno v:
Vaccine. 28:3055-3065
We previously reported the capacity of the cationic lipid-based formulation, Vaxfectin, to enhance the immunogenicity and protective efficacy of a low dose plasmid DNA vaccine against Plasmodium yoelii malaria in mice. Here, we have extended this fin
Autor:
Thomas L. Richie, Daniel J. Carucci, Marilyn Ferrari, Denise L. Doolan, Martha Sedegah, Glenna Banania, David C. Kaslow, William O. Rogers, Arnel Belmonte, Maria Belmonte, Noelle B. Patterson
Publikováno v:
Vaccine. 24:1921-1927
We evaluated the capacity of the cationic lipid based formulation, Vaxfectin, to enhance the immunogenicity and protective efficacy of DNA-based vaccine regimens in the Plasmodium yoelii murine malaria model. We immunized Balb/c mice with varying dos
Autor:
Carl J. Wheeler, Abraham Minsky, Yechezkel Barenholz, Yeshayahu Talmon, Marilyn Ferrari, Dganit Danino, Dmitri Simberg
Publikováno v:
Journal of Biological Chemistry. 276:47453-47459
Mechanisms of cationic lipid-based nucleic acid delivery are receiving increasing attention, but despite this the factors that determine high or low activity of lipoplexes are poorly understood. This study is focused on the fine structure of cationic
Publikováno v:
Journal of Biological Chemistry. 271:15443-15450
Human hepatitis B virus X protein, HBx, is widely acknowledged as a transcriptional transactivator. While HBx has been shown to increase gene expression in trans, it is generally believed that it does not bind double-stranded DNA. Using several exper
Autor:
Daniel Ewing, Shuenn-Jue Wu, Curtis G. Hayes, Kevin R. Porter, Kanakatte Raviprakash, Lan Chen, Nimfa Teneza-Mora, Marilyn Ferrari
Publikováno v:
Vaccine. 30(2)
A prototype dengue-1 DNA vaccine was shown to be safe and immunogenic in a previous Phase 1 clinical trial. Anti-dengue-1 neutralizing antibody responses were detectable only in the group of volunteers receiving the high dose of nonadjuvanted vaccine
Autor:
Marston, Manthorpe, Peter, Hobart, Gary, Hermanson, Marilyn, Ferrari, Andrew, Geall, Blake, Goff, Alain, Rolland
Publikováno v:
Advances in biochemical engineering/biotechnology. 99
In the late 1980s, Vical and collaborators discovered that the injection into tissues of unformulated plasmid encoding various proteins resulted in the uptake of the plasmid by cells and expression of the encoded proteins. After this discovery, a per
Autor:
Alain Rolland, Blake Goff, Marilyn Ferrari, Peter Hobart, Andrew J. Geall, Gary G. Hermanson, Marston Manthorpe
Publikováno v:
Gene Therapy and Gene Delivery Systems ISBN: 9783540284048
In the late 1980s, Vical and collaborators discovered that the injection into tissues of unformulated plasmid encoding various proteins resulted in the uptake of the plasmid by cells and expression of the encoded proteins. After this discovery, a per
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7268b2ab0ab705762b3fb7557477066c
https://doi.org/10.1007/10_003
https://doi.org/10.1007/10_003
Publikováno v:
Nucleic acids research. 30(8)
The large number of cytofectin and co-lipid combinations currently used for lipoplex-mediated gene delivery reflects the fact that the optimal cytofectin/ co-lipid combination varies with the application. The effects of structural changes in both cyt
Autor:
Vesselina Bozoukova, Gita Singh, Walter K. Nishioka, Loretta Sukhu, Mary K. Wloch, Carl J. Wheeler, Joel Enas, Marston Manthorpe, Jukka Hartikka, Marilyn Ferrari, Luane Reyes
Publikováno v:
Vaccine. 19(27)
Antigen specific immune responses were characterized after intramuscular immunization of BALB/c mice with 5 antigen encoding plasmid DNAs (pDNAs) complexed with Vaxfectin, a cationic lipid formulation. Vaxfectin increased IgG titers for all of the an
Publikováno v:
Nucleic acids research. 29(7)
Using a group of structurally related cytofectins, the effects of different vehicle constituents and mixing techniques on the physical properties and biological activity of lipoplexes were systematically examined. Physical properties were examined us