Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Marilisa Neri"'
Autor:
Zhong-Yi Wang, Adrian Keogh, Annick Waldt, Rachel Cuttat, Marilisa Neri, Shanshan Zhu, Sven Schuierer, Alexandra Ruchti, Christophe Crochemore, Judith Knehr, Julie Bastien, Iwona Ksiazek, Daniel Sánchez-Taltavull, Hui Ge, Jing Wu, Guglielmo Roma, Stephen B. Helliwell, Deborah Stroka, Florian Nigsch
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Fibrosis is characterized by the excessive production of collagen and other extracellular matrix (ECM) components and represents a leading cause of morbidity and mortality worldwide. Previous studies of nonalcoholic steatohepatitis (NASH) wi
Externí odkaz:
https://doaj.org/article/1e0a2f5a8461417ea4b3375f454caf3c
Autor:
Rebekka Wegmann, Marilisa Neri, Sven Schuierer, Bilada Bilican, Huyen Hartkopf, Florian Nigsch, Felipa Mapa, Annick Waldt, Rachel Cuttat, Max R. Salick, Joe Raymond, Ajamete Kaykas, Guglielmo Roma, Caroline Gubser Keller
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-21 (2019)
Abstract We develop CellSIUS (Cell Subtype Identification from Upregulated gene Sets) to fill a methodology gap for rare cell population identification for scRNA-seq data. CellSIUS outperforms existing algorithms for specificity and selectivity for r
Externí odkaz:
https://doaj.org/article/39c1e83d8d7d43228770031c5358d8f1
Autor:
Chaoyang Ye, Daniel J. Ho, Marilisa Neri, Chian Yang, Tripti Kulkarni, Ranjit Randhawa, Martin Henault, Nadezda Mostacci, Pierre Farmer, Steffen Renner, Robert Ihry, Leandra Mansur, Caroline Gubser Keller, Gregory McAllister, Marc Hild, Jeremy Jenkins, Ajamete Kaykas
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
RNA-seq is a powerful tool to investigate how drugs affect the transcriptome but library construction can be costly. Here the authors introduce DRUG-seq, an automated platform for high-throughput transcriptome profiling.
Externí odkaz:
https://doaj.org/article/7b7edf1cccfe4d95aaa258f27cffc83f
Autor:
Farah El-Turk, Bruno Fauvet, Amer Ashrafi, Hajer Ouertatani-Sakouhi, Min-Kyu Cho, Marilisa Neri, Michele Cascella, Ursula Rothlisberger, Florence Pojer, Markus Zweckstetter, Hilal Lashuel
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45024 (2012)
Macrophage Migration Inhibitory Factor (MIF) is a key mediator of inflammatory responses and innate immunity and has been implicated in the pathogenesis of several inflammatory and autoimmune diseases. The oligomerization of MIF, more specifically tr
Externí odkaz:
https://doaj.org/article/173f52e6915d41a9bdf61c62b99ddb19
Autor:
Elizabeth Brunk, Ivano Tavernelli, Stefano Vanni, Thomas J. Penfold, Giulia Palermo, Marilisa Neri, Marco Micciarelli, Andrey Laktionov, Julian Garrec, Manuel Doemer, Polydefkis Diamantis, Basile F. E. Curchod, F. Franco de Carvalho, Pablo Campomanes, Prashanth Athri, Negar Ashari, Ursula Rothlisberger
Publikováno v:
CHIMIA, Vol 65, Iss 9 (2011)
The Laboratory of Computational Chemistry and Biochemistry is active in the development and application of first-principles based simulations of complex chemical and biochemical phenomena. Here, we review some of our recent efforts in extending these
Externí odkaz:
https://doaj.org/article/6c7cc0f4b88349b09bdb66ce81ee3c41
Autor:
Basile F. E. Curchod, Pabloc Campomanes, Andrey Laktionov, Marilisa Neri, Thomas J. Penfold, Stefano Vanni, Ivano Tavernelli, Ursula Rothlisberger
Publikováno v:
CHIMIA, Vol 65, Iss 5 (2011)
A thorough theoretical description of ultrafast phenomena that occur in complex systems constitutes a formidable challenge. It not only necessitates the use of quantum mechanical methods that can describe ground and possibly even electronically excit
Externí odkaz:
https://doaj.org/article/92056b4ef8774888b7146a14dc265cdf
Publikováno v:
PLoS Computational Biology, Vol 7, Iss 1, p e1001053 (2011)
Understanding the binding mode of agonists to adrenergic receptors is crucial to enabling improved rational design of new therapeutic agents. However, so far the high conformational flexibility of G protein-coupled receptors has been an obstacle to o
Externí odkaz:
https://doaj.org/article/793fc65429c64147b03e9fcb0b17908d
Autor:
Jingyao Li, Daniel J. Ho, Martin Henault, Chian Yang, Marilisa Neri, Robin Ge, Steffen Renner, Leandra Mansur, Alicia Lindeman, Brian Kelly, Tayfun Tumkaya, Xiaoling Ke, Gilberto Soler-Llavina, Gopi Shanker, Carsten Russ, Marc Hild, Caroline Gubser Keller, Jeremy L. Jenkins, Kathleen A. Worringer, Frederic D. Sigoillot, Robert J. Ihry
Publikováno v:
ACS chemical biology. 17(6)
Unbiased transcriptomic RNA-seq data has provided deep insights into biological processes. However, its impact in drug discovery has been narrow given high costs and low throughput. Proof-of-concept studies with Digital RNA with pertUrbation of Genes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84df92c55bb23f5e3de70243ffd28703
https://pubmed.ncbi.nlm.nih.gov/35508359
https://pubmed.ncbi.nlm.nih.gov/35508359
Autor:
Dhandapani R, Stefanie Joller, Marilisa Neri, Ivan Galimberti, Annick Waldt, Rachel Cuttat, Irena Brzak, Dominik Feuerbach, Rudin S, Guglielmo Roma, Derya R. Shimshek, Tatjana Schweizer, Ulf Neumann, Berth R, Caroline Gubser Keller, Mario Bernhard, Ulrike Naumann, Fabrizio Gasparini
SummaryTREM2 is a transmembrane protein expressed exclusively in microglia in the brain that regulates inflammatory responses to pathological conditions. Proteolytic cleavage of membrane TREM2 affects microglial function and is associated with Alzhei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ebf27af7c06d253b6e85e60ed8e8e2a7
https://doi.org/10.1101/2021.06.23.449405
https://doi.org/10.1101/2021.06.23.449405
Autor:
Kathleen A. Worringer, Robert J. Ihry, Marc Hild, Carsten Russ, Marilisa Neri, Leandra Mansur, Alicia Lindeman, Frederic Sigoillot, Chian Yang, Robin Ge, Jeremy L. Jenkins, Daniel J. Ho, Caroline Gubser Keller, Tayfun Tumkaya, Jingyao Li, Steffen Renner, Martin Henault
Unbiased transcriptomic RNA-seq data has provided deep insights about biological processes. However, its impact in drug discovery has been narrow given high costs and low throughput. Proof-of-concept studies with Digital RNA with pertUrbation of Gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4d7c984cbca815756ba3415d0008b95
https://doi.org/10.1101/2021.06.07.447456
https://doi.org/10.1101/2021.06.07.447456