Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Marilia Barreca"'
Novel tricyclic pyrrolo-quinolines as pharmacological correctors of the mutant CFTR chloride channel
Autor:
Mario Renda, Marilia Barreca, Anna Borrelli, Virginia Spanò, Alessandra Montalbano, Maria Valeria Raimondi, Roberta Bivacqua, Ilaria Musante, Paolo Scudieri, Daniela Guidone, Martina Buccirossi, Michele Genovese, Arianna Venturini, Tiziano Bandiera, Paola Barraja, Luis J. V. Galietta
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract F508del, the most frequent mutation in cystic fibrosis (CF), impairs the stability and folding of the CFTR chloride channel, thus resulting in intracellular retention and CFTR degradation. The F508del defect can be targeted with pharmacologi
Externí odkaz:
https://doaj.org/article/a7ea66016c554c0992a26cad057a85ca
Autor:
Marilia Barreca, Noémie Lang, Chiara Tarantelli, Filippo Spriano, Paola Barraja, Francesco Bertoni
Publikováno v:
Exploration of Targeted Anti-tumor Therapy, Vol 3, Iss 8, Pp 763-794 (2022)
Antibody-drug conjugates (ADCs) are a recent, revolutionary approach for malignancies treatment, designed to provide superior efficacy and specific targeting of tumor cells, compared to systemic cytotoxic chemotherapy. Their structure combines highly
Externí odkaz:
https://doaj.org/article/2ab29059a9fe48fda446247d32770b3e
Autor:
Filippo Spriano, Giulio Sartori, Chiara Tarantelli, Marilia Barreca, Gaetanina Golino, Andrea Rinaldi, Sara Napoli, Michele Mascia, Lorenzo Scalise, Alberto J. Arribas, Luciano Cascione, Emanuele Zucca, Anastasios Stathis, Eugenio Gaudio, Francesco Bertoni
Publikováno v:
eJHaem, Vol 3, Iss 3, Pp 764-774 (2022)
Abstract Inhibitors of the Bromo‐ and Extra‐Terminal domain (BET) family proteins have strong preclinical antitumor activity in multiple tumor models, including lymphomas. Limited single‐agent activity has been reported in the clinical setting.
Externí odkaz:
https://doaj.org/article/932399c982b04d1b9c6bb6911bb32de0
Autor:
Giovanna Li Petri, Ralph Holl, Virginia Spanò, Marilia Barreca, Ignazio Sardo, Maria Valeria Raimondi
Publikováno v:
Frontiers in Chemistry, Vol 11 (2023)
Externí odkaz:
https://doaj.org/article/a24f442c950c41f1b1c248b57e1afbda
Autor:
Roberta Bivacqua, Isabella Romeo, Marilia Barreca, Paola Barraja, Stefano Alcaro, Alessandra Montalbano
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 8, p 7092 (2023)
Protein–protein interactions (PPI) represent attractive targets for drug design. Thus, aiming at a deeper insight into the HSV-1 envelope glycoprotein D (gD), protein–protein docking and dynamic simulations of gD-HVEM and gD-Nectin-1 complexes we
Externí odkaz:
https://doaj.org/article/50df30ee5013470e92bec2095f2f0fd0
Autor:
Katia Grillone, Caterina Riillo, Roberta Rocca, Serena Ascrizzi, Virginia Spanò, Francesca Scionti, Nicoletta Polerà, Annalisa Maruca, Marilia Barreca, Giada Juli, Mariamena Arbitrio, Maria Teresa Di Martino, Daniele Caracciolo, Pierosandro Tagliaferri, Stefano Alcaro, Alessandra Montalbano, Paola Barraja, Pierfrancesco Tassone
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 18, p 10222 (2022)
Microtubule-targeting agents (MTAs) are effective drugs for cancer treatment. A novel diaryl [1,2]oxazole class of compounds binding the colchicine site was synthesized as cis-restricted-combretastatin-A-4-analogue and then chemically modified to hav
Externí odkaz:
https://doaj.org/article/4e40aa15a5c8419991bfb562fea90f74
Autor:
Marilia Barreca, Virginia Spanò, Maria Valeria Raimondi, Chiara Tarantelli, Filippo Spriano, Francesco Bertoni, Paola Barraja, Alessandra Montalbano
Publikováno v:
European Journal of Medicinal Chemistry Reports, Vol 1, Iss , Pp 100004- (2021)
Because of its wide spectrum of targets and biological activities, the oxazole ring is a valuable heterocyclic scaffold in the design of new therapeutic agents with anticancer, antiviral, antibacterial, anti-inflammatory, neuroprotective, antidiabeti
Externí odkaz:
https://doaj.org/article/19046b374f964d0bb7731ec2a44064d5
Autor:
Virginia Spanò, Marilia Barreca, Vincenzo Cilibrasi, Michele Genovese, Mario Renda, Alessandra Montalbano, Luis Juan Vicente Galietta, Paola Barraja
Publikováno v:
Molecules, Vol 26, Iss 5, p 1275 (2021)
Cystic fibrosis (CF) is a genetic disease caused by mutations that impair the function of the CFTR chloride channel. The most frequent mutation, F508del, causes misfolding and premature degradation of CFTR protein. This defect can be overcome with ph
Externí odkaz:
https://doaj.org/article/430009c87c074c6393fa99d7202ad584
Autor:
Marilia Barreca, Virginia Spanò, Alessandra Montalbano, Mercedes Cueto, Ana R. Díaz Marrero, Irem Deniz, Ayşegül Erdoğan, Lada Lukić Bilela, Corentin Moulin, Elisabeth Taffin-de-Givenchy, Filippo Spriano, Giuseppe Perale, Mohamed Mehiri, Ana Rotter, Olivier P. Thomas, Paola Barraja, Susana P. Gaudêncio, Francesco Bertoni
Publikováno v:
Marine Drugs, Vol 18, Iss 12, p 619 (2020)
The marine environment is a rich source of biologically active molecules for the treatment of human diseases, especially cancer. The adaptation to unique environmental conditions led marine organisms to evolve different pathways than their terrestria
Externí odkaz:
https://doaj.org/article/eaf78dfe24d44eb3a3f870f759afa0a3
Autor:
Giulio Sartori, Chiara Tarantelli, Filippo Spriano, Eugenio Gaudio, Luciano Cascione, Michele Mascia, Marilia Barreca, Alberto J. Arribas, Luca Licenziato, Gaetanina Golino, Adele Ferragamo, Stefano Pileri, Giovanna Damia, Emanuele Zucca, Anastasios Stathis, Oliver Politz, Antje M. Wengner, Francesco Bertoni
PurposeThe DNA damage response (DDR) is the cellular process devoted to the preservation of an intact genome. The DDR is often deregulated in lymphoma cells due to high levels of DNA damage, tumor suppressor inactivation, increased replication stress
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09d5fa43dad77dcbd07ab351243dfb2f
https://doi.org/10.1101/2023.02.10.528011
https://doi.org/10.1101/2023.02.10.528011