NRXN1 Deletion and Exposure to Methylmercury Increase Astrocyte Differentiation by Different Notch-Dependent Transcriptional Mechanisms

Autor: Marilena Raciti, Jahan Salma, Stefan Spulber, Giulia Gaudenzi, Zahra Khalajzeyqami, Mirko Conti, Britt-Marie Anderlid, Anna Falk, Ola Hermanson, Sandra Ceccatelli

Publikováno v: Frontiers in Genetics, Vol 10 (2019)

Controversial evidence points to a possible involvement of methylmercury (MeHg) in the etiopathogenesis of autism spectrum disorders (ASD). In the present study, we used human neuroepithelial stem cells from healthy donors and from an autistic patien

Externí odkaz: https://doaj.org/article/c64641e2469a42cda30c8045bce5c6ee

AMBRA1 regulates cyclin D to guard S-phase entry and genomic integrity

Autor: Armando Bartolazzi, Marilena Raciti, Valentina Cianfanelli, Jiri Bartek, Rosalie C. Sears, Rikke Darling Rasmussen, Elena Papaleo, Jirina Bartkova, Guillermo Velasco, Miriam Di Marco, Robert E. Hynds, Francesco Russo, Petra Hamerlik, Salvatore Rizza, Emanuela Pupo, Cristiano De Stefanis, Franco Locatelli, Charles Swanton, Joanna Maria Merchut-Maya, Michele Pagano, Daniele Simoneschi, Søs Grønbæk Holdgaard, Letizia Lanzetti, Gergely Róna, Giacomo Milletti, Nélida Salvador, Giuseppe Filomeni, Luca Di Leo, Daniela De Zio, Francesca Nazio, Colin J. Daniel, Apolinar Maya-Mendoza, Alfie O’sullivan, Estibaliz Gabicagogeascoa, Angela Gallo, Francesco Cecconi, Silvia Campello, Matteo Bordi, Costanza Montagna, Yeon Tae Jeong, Valeriana Cesarini, David R. Pearce, Mar Lorente, Emiliano Maiani, Pasquale D’Acunzo, Marianna Carinci

Publikováno v: Nature (Lond.) 592 (2021): 799–803. doi:10.1038/s41586-021-03422-5
info:cnr-pdr/source/autori:Maiani E.; Milletti G.; Nazio F.; Holdgaard S.G.; Bartkova J.; Rizza S.; Cianfanelli V.; Lorente M.; Simoneschi D.; Di Marco M.; D'Acunzo P.; Di Leo L.; Rasmussen R.; Montagna C.; Raciti M.; De Stefanis C.; Gabicagogeascoa E.; Rona G.; Salvador N.; Pupo E.; Merchut-Maya J.M.; Daniel C.J.; Carinci M.; Cesarini V.; O'sullivan A.; Jeong Y.-T.; Bordi M.; Russo F.; Campello S.; Gallo A.; Filomeni G.; Lanzetti L.; Sears R.C.; Hamerlik P.; Bartolazzi A.; Hynds R.E.; Pearce D.R.; Swanton C.; Pagano M.; Velasco G.; Papaleo E.; De Zio D.; Maya-Mendoza A.; Locatelli F.; Bartek J.; Cecconi F./titolo:AMBRA1 regulates cyclin D to guard S-phase entry and genomic integrity/doi:10.1038%2Fs41586-021-03422-5/rivista:Nature (Lond.)/anno:2021/pagina_da:799/pagina_a:803/intervallo_pagine:799–803/volume:592
Nature
Maiani, E, Milletti, G, Nazio, F, Holdgaard, S G, Bartkova, J, Rizza, S, Cianfanelli, V, Lorente, M, Simoneschi, D, Di Marco, M, D'Acunzo, P, Di Leo, L, Rasmussen, R, Montagna, C, Raciti, M, De Stefanis, C, Gabicagogeascoa, E, Rona, G, Salvador, N, Pupo, E, Merchut-Maya, J M, Daniel, C J, Carinci, M, Cesarini, V, O'sullivan, A, Jeong, Y-T, Bordi, M, Russo, F, Campello, S, Gallo, A, Filomeni, G, Lanzetti, L, Sears, R C, Hamerlik, P, Bartolazzi, A, Hynds, R E, Pearce, D R, Swanton, C, Pagano, M, Velasco, G, Papaleo, E, De Zio, D, Maya-Mendoza, A, Locatelli, F, Bartek, J & Cecconi, F 2021, ' AMBRA1 regulates cyclin D to guard S-phase entry and genomic integrity ', Nature, vol. 592, pp. 799-803 . https://doi.org/10.1038/s41586-021-03422-5

Mammalian development, adult tissue homeostasis and the avoidance of severe diseases including cancer require a properly orchestrated cell cycle, as well as error-free genome maintenance. The key cell-fate decision to replicate the genome is controll

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eb3a5f17bd536c3cceee8b07b588edc
https://hdl.handle.net/11590/423288

Gestational Age and Sex Influence the Susceptibility of Human Neural Progenitor Cells to Low Levels of MeHg

Autor: Erik Sundström, Michaela Moors, Sandra Ceccatelli, Karin Edoff, Marilena Raciti

Publikováno v: Neurotoxicity Research

The developing nervous system is highly susceptible to methylmercury (MeHg), a widespread environmental neurotoxic contaminant. A wide range of morphological and functional outcomes have been described; however, there are still open questions regardi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61a37f1a65570651271176a8d67befd2
http://europepmc.org/articles/PMC5602033

Glucocorticoids alter neuronal differentiation of human neuroepithelial-like cells by inducing long-lasting changes in the reactive oxygen species balance

Autor: Sandra Ceccatelli, Laura Weis, Marilena Raciti, Anna Falk, Cristina Battagli, Karin Edoff, Jennie Ong

Publikováno v: Neuropharmacology. 107:422-431

Prenatal exposure to excess glucocorticoid has been shown to have adverse effects on the developing nervous system that may lead to alterations of fetal and adult neurogenesis, resulting in behavioral changes. In addition, an imbalance of the redox s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64034ff06efe9d468358692f5992e316
https://doi.org/10.1016/j.neuropharm.2016.03.022

Methylmercury interferes with glucocorticoid receptor: Potential role in the mediation of developmental neurotoxicity

Autor: Diana Lupu, Beata Dulko-Smith, Joëlle Rüegg, Kwangho Nam, Stefan Spulber, Sandra Ceccatelli, Marilena Raciti

Publikováno v: Toxicology and applied pharmacology. 354

Methylmercury (MeHg) is a widespread environmental contaminant with established developmental neurotoxic effects. Computational models have identified glucocorticoid receptor (GR) signaling to be a key mediator behind the birth defects induced by Hg,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13da009b3b42755e555957da5e4fddc0
https://pubmed.ncbi.nlm.nih.gov/29499248