Výsledky vyhledávání - "Marilen Federico"

Akademický článek

CaMKII activation in early diabetic hearts induces altered sarcoplasmic reticulum-mitochondria signaling

Autor: Marilen Federico, Maite Zavala, Tamara Vico, Sofía López, Enrique Portiansky, Silvia Alvarez, Maria Celeste Villa Abrille, Julieta Palomeque

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)

Abstract Prediabetic myocardium, induced by fructose-rich diet (FRD), is prone to increased sarcoplasmic reticulum (SR)-Ca2+ leak and arrhythmias due to increased activity of the Ca2+/calmodulin protein kinase II (CaMKII). However, little is known ab

Externí odkaz: https://doaj.org/article/8a54e36dee0342b9aa851469f3efb5b0

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Non-conventional mitochondrial permeability transition: Its regulation by mitochondrial dynamics

Autor: Yisang Yoon, Hakjoo Lee, Marilen Federico, Shey-Shing Sheu

Publikováno v: Biochimica et biophysica acta. Bioenergetics. 1864(1)

Mitochondrial permeability transition (MPT) is a phenomenon that the inner mitochondrial membrane (IMM) loses its selective permeability, leading to mitochondrial dysfunction and cell injury. Electrophysiological evidence indicates the presence of a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e37fed47441a9ff96a93362b33b362b
https://pubmed.ncbi.nlm.nih.gov/36063902

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CaMKII activation in early diabetic hearts induces altered sarcoplasmic reticulum-mitochondria signaling

Autor: Maite Zavala, Tamara Vico, María Celeste Villa Abrille, Silvia Alvarez, Enrique Leo Portiansky, Marilen Federico, Julieta Palomeque, Sofía López

Publikováno v: SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Scientific Reports

Prediabetic myocardium, induced by fructose-rich diet (FRD), is prone to increased sarcoplasmic reticulum (SR)-Ca2+ leak and arrhythmias due to increased activity of the Ca2+/ calmodulin protein kinase II (CaMKII). However, little is known about the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faabf0124f244b517f24f9ddf3ef8d34
https://doi.org/10.1038/s41598-021-99118-x

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Calcium-calmodulin-dependent protein kinase mediates the intracellular signalling pathways of cardiac apoptosis in mice with impaired glucose tolerance

Autor: Marilen, Federico, Enrique L, Portiansky, Leandro, Sommese, Francisco J, Alvarado, Paula G, Blanco, Carolina N, Zanuzzi, John, Dedman, Marcia, Kaetzel, Xander H T, Wehrens, Alicia, Mattiazzi, Julieta, Palomeque

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP

The impact of cardiac apoptosis in pre-diabetic stages of diabetic cardiomyopathy is unknown. We show that myocytes from fructose-rich diet (FRD) animals exhibit arrhythmias produced by exacerbated Ca2+/calmodulin-protein kinase (CaMKII) activity, ry

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a9ee08c750a0d814b6689b66603bb290
Wiley Online Library

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Akademický článek

Unbalance Between Sarcoplasmic Reticulum Ca2 + Uptake and Release: A First Step Toward Ca2 + Triggered Arrhythmias and Cardiac Damage

Autor: Marilén Federico, Carlos A. Valverde, Alicia Mattiazzi, Julieta Palomeque

Publikováno v: Frontiers in Physiology, Vol 10 (2020)

The present review focusses on the regulation and interplay of cardiac SR Ca2+ handling proteins involved in SR Ca2+ uptake and release, i.e., SERCa2/PLN and RyR2. Both RyR2 and SERCA2a/PLN are highly regulated by post-translational modifications and

Externí odkaz: https://doaj.org/article/7ab255aaa9924f0f9255615c6e56d956

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