Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Marilee Lougheed"'
Autor:
Alison Buchan, Hiroshi Suzuki, Urs P. Steinbrecher, Marilee Lougheed, Wenhua Ling, Tatsuhiko Kodama
Publikováno v:
Scopus-Elsevier
Oxidized low density lipoprotein (LDL) and acetyl LDL are recognized by the scavenger receptor class A type I/II (SR-AI/II) on macrophages and liver endothelial cells. Several investigators have suggested that there are additional receptors specific
Autor:
Guenter K. Eigendorf, Emma S. Tomlinson Guns, Maziar Riazy, Marilee Lougheed, Hans Adomat, Vincent Duronio, Urs P. Steinbrecher
Publikováno v:
Free radical biologymedicine. 51(10)
Macrophages are prominent components of human atherosclerotic lesions and they are believed to accelerate the progression and/or complications of both early and advanced atherosclerotic lesions. We and others have shown that oxidized low-density lipo
Publikováno v:
Journal of Biological Chemistry. 266:14519-14525
The rate of uptake of oxidized low density lipoprotein (LDL) by mouse peritoneal macrophages is similar to that of acetyl LDL; but only approximately 50% of the internalized oxidized LDL is ultimately degraded, in contrast to the near-complete degrad
Publikováno v:
Free Radical Biology and Medicine. 9:155-168
Oxidative modification of LDL is accompanied by a number of compositional and structural changes, including increased electrophoretic mobility, increased density, fragmentation of apolipoprotein B, hydrolysis of phosphatidylcholine, derivatization of
Publikováno v:
Journal of cardiovascular pharmacology. 41(6)
Previous studies have shown that oxidized low-density lipoprotein (LDL) can impair endothelial function and that this can be overcome in vivo by administration of vitamin E. However, it is unclear whether this effect of oxidized LDL is due to lysopho
Publikováno v:
Arteriosclerosis, thrombosis, and vascular biology. 19(8)
Abstract —Accumulation of cholesterol by macrophage foam cells in atherosclerotic lesions is thought to involve the uptake of modified low density lipoproteins (LDLs). Previous studies have shown that there is impaired degradation of oxidized LDL i
Publikováno v:
The Journal of biological chemistry. 274(16)
It has recently been shown that macrophage proliferation occurs during the progression of atherosclerotic lesions and that oxidized low density lipoprotein (LDL) stimulates macrophage growth. Possible mechanisms for this include the interaction of ox
Autor:
Marilee Lougheed, Urs P. Steinbrecher
Publikováno v:
The Journal of biological chemistry. 271(20)
Several investigators have reported nonreciprocal cross-competition between unlabeled acetyl low density lipoprotein (LDL) and oxidized LDL for the degradation of the corresponding labeled LDLs. The failure of acetyl LDL to compete fully for the degr
Publikováno v:
Biochemistry and cell biology = Biochimie et biologie cellulaire. 73(1-2)
It is believed that the major mechanisms by which hydroxymethylglutaryl coenzyme A reductase inhibitors lower plasma cholesterol levels are by inducing hepatic low-density lipoprotein (LDL) receptor activity and by decreasing apolipoprotein B (apoB)
Autor:
Marilee Lougheed, Urs P. Steinbrecher
Publikováno v:
Arteriosclerosis and thrombosis : a journal of vascular biology. 12(5)
There is a growing body of evidence that suggests that modification of low density lipoprotein (LDL) in the artery wall may contribute to atherogenesis. A number of physiologically plausible modifications have been studied in vitro, including oxidati