Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Mariko Nishiguchi"'
Autor:
Mariko Nishiguchi, Michihiko Iijima, Toshiharu Shimazaki, Takeo Funakoshi, Yoshinori Sekiguchi, Shigeyuki Chaki, Akie Ito, Kosuke Kanuma
Publikováno v:
Pharmacology Biochemistry and Behavior. 135:154-168
Melanin-concentrating hormone receptor 1 (MCH1 receptor) is known to be involved in the control of mood and stress, in addition to the regulation of feeding. Here, we report further evidence that the blockade of the MCH1 receptor exhibits antidepress
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e2620add1fedeb4934ab5b215f4d8e7
https://doi.org/10.1016/j.pbb.2015.05.018
https://doi.org/10.1016/j.pbb.2015.05.018
Autor:
Bill Thomsen, Mariko Nishiguchi, Debbie Hsu, Graeme Semple, Katsunori Omodera, Bryan A. Kramer, Kosuke Kanuma, Takeo Funakoshi, Martin Casper, Thuy-Anh Tran, Yoshinori Sekiguchi, Shigeyuki Chaki
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:3853-3856
The optimization of a series of 4-(dimethylamino)quinazoline antagonists of the melanin-concentrating hormone receptor 1 (MCH-R1) is described. The combination of the elaboration of both the linker portion and the terminal phenyl ring provided N-(cis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15e987826fcdc01f103b851dfb8229b6
https://doi.org/10.1016/j.bmcl.2005.05.121
https://doi.org/10.1016/j.bmcl.2005.05.121
Autor:
Kenzo Takahashi, Koshi Arai, Takeo Kobori, Tomoko Akama, Yasumitsu Tomishima, Minoru Taguchi, Kenichi Goda, Kikuo Sugimoto, Mariko Nishiguchi, Taizo Suzuki, Kyoko Yamamoto
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:1963-1966
To search for neutral sphingomyelinase inhibitors we designed and synthesized hydrolytically stable analogues of sphingomyelin. The novel compounds 8 and 9 which were replaced the phosphodiester moiety of sphingomyelin with the carbamate moiety showe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::662efe062437dcc8cbe28da6bec560e8
https://doi.org/10.1016/s0960-894x(03)00360-3
https://doi.org/10.1016/s0960-894x(03)00360-3
Autor:
Tomokazu Ueki, Kimiko Tokugawa, Shigeyuki Chaki, Yuriko Nozawa, Shigeru Okuyama, Tomoko Akama, Kyoko Yamamoto, Mariko Nishiguchi, Kazuya Kameo
Publikováno v:
Neurochemistry International. 42:493-498
Glial cell line-derived neurotrophic factor (GDNF) was reported to be effective for treating subjects with neurodegenerative diseases such as Parkinson’s disease. In search of finding a compound which promotes GDNF secretion, we found that concanam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::385bb6f587c776a4680f13dde10f6dcd
https://doi.org/10.1016/s0197-0186(02)00139-0
https://doi.org/10.1016/s0197-0186(02)00139-0
Autor:
Kyoko Yamamoto, Masahiko Sakai, Kimiko Tokugawa, Shigeyuki Chaki, Tomokazu Ueki, Mariko Nishiguchi, Takumi Sekine, Shigeru Okuyama
Publikováno v:
Neurochemistry International. 42:81-86
We investigated the agonistic activities of N(4)-(7-chloro-2-[(E)-2-(2-chloro-phenyl)-vinyl]-quinolin-4-yl)-N(1),N(1)-diethyl-pentane-1,4-diamine (XIB4035), at the glial cell line-derived neurotrophic factor (GDNF) family receptoralpha-1(GFRalpha-1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b39e611aa28e7d18d15ec0304847495f
https://doi.org/10.1016/s0197-0186(02)00053-0
https://doi.org/10.1016/s0197-0186(02)00053-0
Autor:
Junichi Yamaguchi, Katsunori Omodera, Takeo Funakoshi, Yoshinori Sekiguchi, Shigeyuki Chaki, Izumi Iida, Kosuke Kanuma, Graeme Semple, Yasuko Nagase, Mariko Nishiguchi, Thuy-Anh Tran
Publikováno v:
Bioorganicmedicinal chemistry. 14(10)
The optimization of the distance between two key pharmacophore features within our first hit compounds 1a and 2a led to the identification of a new class of potent non-peptidic antagonists for the MCH-R1, based around 4-amino-2-cyclohexylaminoquinazo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a759c032fe07116d64e1002dbddd3448
https://pubmed.ncbi.nlm.nih.gov/16434202
https://pubmed.ncbi.nlm.nih.gov/16434202
Autor:
Katsunori Omodera, Andrew J. Grottick, Kosuke Kanuma, Takeo Funakoshi, Mariko Nishiguchi, Shigeru Okuyama, Yoshinori Sekiguchi, Shigeyuki Chaki, William Thomsen, Graeme Semple, Toshiharu Shimazaki, Michihiko Iijima, Thuy-Anh Tran, Shiho Hirota-Okuno
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 313(2)
Melanin-concentrating hormone (MCH) is a cyclic peptide produced in the lateral hypothalamus. It has been implicated in a number of physiological processes including feeding behavior, energy balance, and the regulation of emotional states. Here, we r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94b5240a6512f9162acc29fd806781cf
https://pubmed.ncbi.nlm.nih.gov/15677346
https://pubmed.ncbi.nlm.nih.gov/15677346
Autor:
Debbie Hsu, Thuy-Anh Tran, Nigel Robert Arnold Beeley, Kosuke Kanuma, Bill Thomsen, Mariko Nishiguchi, Graeme Semple, Takeo Funakoshi, Yoshinori Sekiguchi, Shigeyuki Chaki, Bryan A. Kramer, Katsunori Omodera, Martin Casper
Publikováno v:
Bioorganicmedicinal chemistry letters. 15(10)
A series of 4-(dimethylamino)quinazoline based antagonists of the melanin-concentrating hormone receptor 1 (MCH-R1) is described. This series was derived from a lead compound, AR129330, identified by HTS of a GPCR-directed library using a functional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dd585ed9c041dc0a0656e2b5816dc47
https://pubmed.ncbi.nlm.nih.gov/15863317
https://pubmed.ncbi.nlm.nih.gov/15863317
Autor:
Takeo Kobori, Kikuo Sugimoto, Tomoko Akama, Kyoko Yamamoto, Koshi Arai, Mariko Nishiguchi, Yasumitsu Tomishima, Minoru Taguchi, Kenzo Takahashi, Taizo Suzuki, Kenichi Goda
Publikováno v:
Bioorganicmedicinal chemistry letters. 13(21)
Seeking neutral sphingomyelinase inhibitors, we designed and synthesized hydrolytically stable analogues of sphingomyelin. These novel analogues replace the phosphodiester moiety of sphingomyelin with carbamate and urea moiety, resulting in inhibitio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::693225e0ad0b62ed41ee08e42a2c0e7f
https://pubmed.ncbi.nlm.nih.gov/14552757
https://pubmed.ncbi.nlm.nih.gov/14552757