Association of the hypoxia-inducible factor-1α (HIF-1α) gene polymorphisms with prognosis in ovarian clear cell carcinoma

Autor: Hiroyuki Suzuki, Mitsutake Yano, Mariko Miyazawa, Masaki Miyazawa, Naoki Ogane, Kosei Hasegawa, Hitoshi Tsuda, Masayuki Yoshida, Ryugo Okagaki, Osamu Ishihara, Masanori Yasuda

Publikováno v: Journal of Ovarian Research, Vol 12, Iss 1, Pp 1-7 (2019)

Abstract Background Ovarian clear cell carcinoma (OCCC) is the second most common ovarian cancer after serous carcinoma in Japan. OCCC has a more unfavorable clinical outcome due to a poor response to platinum-based chemotherapy, compared with serous

Externí odkaz: https://doaj.org/article/f258d5e0d7ec4a1791d8e6ee7fcb4b5e

Identification of tumor antigens in ovarian cancers using local and circulating tumor���specific antibodies

Autor: Masaru Hayashi, Andreas Behren, Alexander Lopata, Jessica Da Gama Duarte, Mariko Miyazawa, Luke Quigley, Nunzio Sebastiano Mancuso, Anna Rachel Young, Els N.T. Meeusen, Mikio Mikami

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 11220, p 11220 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 20

Ovarian cancers include several disease subtypes and patients often present with advanced metastatic disease and a poor prognosis. New biomarkers for early diagnosis and targeted therapy are, therefore, urgently required. This study uses antibodies p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd89bccf52853c0388d9a6c13315ae0d

Clinicopathological correlation of ARID1A status with HDAC6 and its related factors in ovarian clear cell carcinoma

Autor: Tomomi Katoh, Maiko Miwa, Masaki Miyazawa, Kosei Hasegawa, Mariko Miyazawa, Naoki Ogane, Mitsutake Yano, Masanori Yasuda, Hisashi Narahara

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Scientific Reports

Ovarian clear cell carcinoma (OCCC) is associated with a frequent loss in ARID1A function. ARID1A reportedly suppresses histone deacetylase (HDAC)6 in OCCC directly. Here, we evaluated the clinical significance of HDAC6 expression and its related fac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84d2df6b173dafb50e1ab6b8e076d08a
http://link.springer.com/article/10.1038/s41598-019-38653-0

Up-Regulation of HDAC6 Results in Poor Prognosis and Chemoresistance in Patients with Advanced Ovarian High-Grade Serous Carcinoma

Autor: Masanori Yasuda, Hisashi Narahara, Naoki Ogane, Kosei Hasegawa, Aiko Ogasawara, Mariko Miyazawa, Mitsutake Yano

Background: Ovarian high-grade serous carcinoma (HGSC) gradually acquires chemoresistance after recurrence. In our previous study on ovarian clear cell carcinoma, histone deacetylase 6 (HDAC6) led to chemoresistance. This study aimed to evaluate HDAC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a107880659090b930627c51069642b2
https://doi.org/10.21203/rs.3.rs-40241/v1

Association of histone deacetylase expression with histology and prognosis of ovarian cancer

Autor: Takashi Fujino, Koji Nagata, Mitsutake Yano, Masanori Yasuda, Eiichi Arai, Hisashi Narahara, Masaki Miyazawa, Mika Sakaki, Takahiro Hasebe, Naoki Ogane, Kosei Hasegawa, Mariko Miyazawa

Publikováno v: Oncology Letters

Histone deacetylase (HDAC) inhibitor is known to have a cytotoxic effect on ovarian cancer cell lines. The present study analyzed the association between immunohistochemical HDAC expression and clinicopathological findings, in particular, the associa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::807aa411e594c6cbf7bdf9d5874feb84
http://europepmc.org/articles/PMC5795841