Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Marikka Elia"'
Autor:
Sarah B Dicker, Tatiyana L. Shiyanova, Patel Chetankumar Natvarlal, Stephanie Marie Truhlar, Robert J. Benschop, Stuart W. Bright, Dongmei He, Oliver Schroeder, Katie Brannon Corwin, Marikka Elia, Qing Zhang, Julian Davies, Lukasz K. Chlewicki, Angela J. Okragly
Publikováno v:
Journal of Inflammation Research
Angela J Okragly,1 Katie Brannon Corwin,2 Marikka Elia,3 Dongmei He,3 Oliver Schroeder,3 Qing Zhang,3 Tatiyana Shiyanova,2 Stuart Bright,1 Sarah B Dicker,4 Lukasz Chlewicki,4 Stephanie ME Truhlar,3 Julian Davies,3 Chetan N Patel,2 Robert J Benschop1
Autor:
Xochitl Cortez, Lisa Kerwin, Roberta P. Fuller, Carlos F. Barbas, Diane Kubitz, Marikka Elia, Alexei Licea, Jody D. Berry, Mikhail Popkov
Publikováno v:
Hybridoma and Hybridomics. 22:23-31
Dendritic cells (DC) are the professional antigen-presenting cells of the immune system. Previous studies have demonstrated that targeting foreign antigens to DC leads to enhanced antigen (Ag)-specific responses in vivo. However, the utility of this
Publikováno v:
Journal of Biological Chemistry. 275:36073-36078
We describe the isolation of a CCR5-specific antibody, ST6, from an antibody phage display library generated from an immune rabbit. ST6 was previously shown to efficiently prevent the surface expression of CCR5 when expressed intracellularly (Steinbe
Autor:
Lloyd J. Old, Leonard Cohen, Christoph Rader, Ivan Gout, Gerd Ritter, Marikka Elia, Achim A. Jungbluth, Sydney Welt, Carlos F. Barbas, Sheila Nathan
Publikováno v:
Journal of Biological Chemistry. 275:13668-13676
The rabbit antibody repertoire, which in the form of polyclonal antibodies has been used in diagnostic applications for decades, would be an attractive source for the generation of therapeutic human antibodies. The humanization of rabbit antibodies,
Autor:
Bruce E. Kimmel, Gary Woodnutt, Mangala Hariharan, Geneviève Hansen, Marikka Elia, Ping Jin, Jay M. Short, Michael Dudley, Stephen J Demarest, Jared Salbato, Colin Bird
Publikováno v:
mAbs. 2(2)
The pathogenicity of Clostridium difficile (C. difficile) is mediated by the release of two toxins, A and B. Both toxins contain large clusters of repeats known as cell wall binding (CWB) domains responsible for binding epithelial cell surfaces. Seve
Autor:
John Poland, David Gustafson, Ken Wong, Marikka Elia, Bruce E. Kimmel, Jay M. Short, Jane Wu, Stephen J. Demarest, Xuqiu Tan, Geneviève Hansen, Gang Chen, Jared Salbato
Publikováno v:
Protein engineering, designselection : PEDS. 19(7)
The recombinant expression of immunoglobulin domains, Fabs and scFvs in particular, in Escherichia coli can vary significantly from antibody to antibody. We hypothesized that poor Fab expression is often linked to poor intrinsic stability. To investi
Autor:
Gary Woodnutt, Stephen J. Demarest, Jingping Zhong, Katie Kline, Marikka Elia, Bruce E. Kimmel, Geneviève Hansen, Theresa Morrow, Trevin Holland, Jared Salbato
Publikováno v:
Journal of molecular biology. 346(5)
Clostridium difficile ( C. difficile ) is a nosocomially acquired intestinal bacillus which can cause chronic diarrhea and life-threatening colitis. The pathogenic effects of the bacillus are mediated by the release of two toxins, A and B. The C-term
Autor:
Gregg J. Silverman, John Rutherford, Marikka Elia, Carlos F. Barbas, Jody D. Berry, Rupert Kaul, Roberta P. Fuller, Sarah Gobuty, Francis A. Plummer
Publikováno v:
Hybridoma and hybridomics. 22(2)
A panel of novel recombinant single-chain variable fragment (scFv) antibody against human immunodeficiency virus type-1 (HIV-1) was isolated and characterized. We generated human scFvs using RNA harvested from cervical B lymphocytes of Kenyan prostit
Autor:
Lian-Sheng Li, Lucy Lan, Katrina Chan, Linda Kessler, Angelina Luzader, Michael C. Martin, Katti Jessen, Yi Liu, Jocelyn Staunton, Jeff Kucharski, Matthew R. Janes, Josh Stewart, Levan Darjania, Urmi Banerjee, Xin Guo, Shunyou Wang, Marikka Elia, Pingda Ren, Christian Rommel
Publikováno v:
Cancer Research. 72:2745-2745
Background: The mammalian target of rapamycin (mTOR), which comprises two protein complexes, TORC1 and TORC2, regulates tumor cell growth, metabolism and motility. In endometrial cancer, the mTOR pathway is aberrantly activated by constitutive mitoge
Autor:
Katti Jessen, Marikka Elia, Yi Liu, Jocelyn Staunton, Matthew R. Janes, Xin Guo, Christian Rommel
Publikováno v:
Cancer Research. 72:2812-2812
Background: Early events of metastatic dissemination arise from the ability of tumor cells to acquire a number of biological changes which allow for their survival in distal microenvironments. Among the early events that initiate disseminated tumor p