Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Marika Nestor"'
Autor:
Katrine Ingelshed, Marit M. Melssen, Pavitra Kannan, Arun Chandramohan, Anthony W. Partridge, Long Jiang, Fredrik Wermeling, David P. Lane, Marika Nestor, Diana Spiegelberg
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109862- (2024)
Summary: Immunotherapy has revolutionized cancer treatment but its efficacy depends on a robust immune response in the tumor. Silencing of the tumor suppressor p53 is common in tumors and can affect the recruitment and activation of different immune
Externí odkaz:
https://doaj.org/article/a6f5c387d3ed4365a35bb503c9592eba
Autor:
Arun Chandramohan, Hubert Josien, Tsz Ying Yuen, Ruchia Duggal, Diana Spiegelberg, Lin Yan, Yu-Chi Angela Juang, Lan Ge, Pietro G. Aronica, Hung Yi Kristal Kaan, Yee Hwee Lim, Andrea Peier, Brad Sherborne, Jerome Hochman, Songnian Lin, Kaustav Biswas, Marika Nestor, Chandra S. Verma, David P. Lane, Tomi K. Sawyer, Robert Garbaccio, Brian Henry, Srinivasaraghavan Kannan, Christopher J. Brown, Charles W. Johannes, Anthony W. Partridge
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Although stapled α-helical peptides can address challenging targets, their advancement is impeded by poor understandings for making them cell permeable while avoiding off-target toxicities. By synthesizing >350 molecules, we present workflo
Externí odkaz:
https://doaj.org/article/244b34e3aef44b508696598d0927724f
Autor:
Tina Sarén, Giulia Saronio, Paula Marti Torrell, Xu Zhu, Josefin Thelander, Yasmin Andersson, Camilla Hofström, Marika Nestor, Anna Dimberg, Helena Persson, Mohanraj Ramachandran, Di Yu, Magnus Essand
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Chimeric antigen receptor (CAR)-T cell therapy is rapidly advancing as cancer treatment, however, designing an optimal CAR remains challenging. A single-chain variable fragment (scFv) is generally used as CAR targeting moiety, wherein the co
Externí odkaz:
https://doaj.org/article/c97dd91fb4d34f1e8111dd6c28476906
Autor:
Xin Yu Koh, Xiao Hui Koh, Diana Spiegelberg, Preeti Jha, Marika Nestor, Le-ann Hwang, Ban Xiong Tan, David Philip Lane
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract The RON receptor tyrosine kinase is an exceptionally interesting target in oncology and immunology. It is not only overexpressed in a wide variety of tumors but also has been shown to be expressed on myeloid cells associated with tumor infil
Externí odkaz:
https://doaj.org/article/7630592839b745e4807f205edee05a36
Autor:
Tabassom Mohajershojai, Douglas Spangler, Saloni Chopra, Fredrik Y. Frejd, Paul J. Yazaki, Marika Nestor
Publikováno v:
Cancers, Vol 15, Iss 17, p 4239 (2023)
Carcinoembryonic antigen (CEA) has emerged as an attractive target for theranostic applications in colorectal cancers (CRCs). In the present study, the humanized anti-CEA antibody hT84.66-M5A (M5A) was labeled with 177Lu for potential CRC therapy. Mo
Externí odkaz:
https://doaj.org/article/846c38d8673442c984c31c5178e49055
Autor:
Tabassom Mohajershojai, Preeti Jha, Anna Boström, Fredrik Y. Frejd, Paul J. Yazaki, Marika Nestor
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Carcinoembryonic antigen (CEA) is an antigen that is highly expressed in colorectal cancers and widely used as a tumor marker. 131I and 90Y-radiolabeled anti-CEA monoclonal antibodies (mAbs) have previously been assessed for radioimmunotherapy in ear
Externí odkaz:
https://doaj.org/article/4fe414bf2d204697b6e74e4f33eaaeb6
Publikováno v:
EJNMMI Research, Vol 10, Iss 1, Pp 1-10 (2020)
Abstract Background Precision therapeutics continuously make advances in cancer therapy, and a field of growing interest is the combination of targeted radionuclide therapy (TRNT) with potential radiosensitizing agents. This study evaluated whether t
Externí odkaz:
https://doaj.org/article/64ae9c8426374e3cadd7201d385cfbf2
Autor:
Diana Spiegelberg, Anja Charlotte Lundgren Mortensen, Kartika Dyah Palupi, Patrick Micke, Julin Wong, Borivoj Vojtesek, David Philip Lane, Marika Nestor
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
RationalcMet is abnormally regulated in gastrointestinal cancer, and is associated with increased invasiveness of the disease and poor overall survival. There are indications that targeted therapy against cMet, alone or in combination with additional
Externí odkaz:
https://doaj.org/article/5432d99071b24b57adc1dde95164618e
Autor:
Patrik Johansson, Cecilia Krona, Soumi Kundu, Milena Doroszko, Sathishkumar Baskaran, Linnéa Schmidt, Claire Vinel, Elin Almstedt, Ramy Elgendy, Ludmila Elfineh, Caroline Gallant, Sara Lundsten, Fernando J. Ferrer Gago, Aleksi Hakkarainen, Petra Sipilä, Maria Häggblad, Ulf Martens, Bo Lundgren, Melanie M. Frigault, David P. Lane, Fredrik J. Swartling, Lene Uhrbom, Marika Nestor, Silvia Marino, Sven Nelander
Publikováno v:
Cell Reports, Vol 32, Iss 2, Pp 107897- (2020)
Summary: Glioblastoma (GBM) is a malignant brain tumor with few therapeutic options. The disease presents with a complex spectrum of genomic aberrations, but the pharmacological consequences of these aberrations are partly unknown. Here, we report an
Externí odkaz:
https://doaj.org/article/cc573e6ed9f44191ba0a80782a5d717e
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
Based on their mechanism of action, two types of anti-CD20 antibodies are distinguished: Type I, which efficiently mediate complement-dependent cytotoxicity, and Type II, which instead are more efficient in inducing direct cell death. Several molecul
Externí odkaz:
https://doaj.org/article/ee2e51128a5a4f9099ce7c3ce4cdc785