Zobrazeno 1 - 10 of 22 pro vyhledávání: '"Marika Guerra"'
1
Akademický článek
Unravelling the Cerebellar Involvement in Autism Spectrum Disorders: Insights into Genetic Mechanisms and Developmental Pathways
Autor: Marika Guerra, Vanessa Medici, Gina La Sala, Donatella Farini
Publikováno v: Cells, Vol 13, Iss 14, p 1176 (2024)
Autism spectrum disorders (ASDs) are complex neurodevelopmental conditions characterized by deficits in social interaction and communication, as well as repetitive behaviors. Although the etiology of ASD is multifactorial, with both genetic and envir
Externí odkaz: https://doaj.org/article/78225cdba2fb4a6399a535e25e62ff5a
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2
Akademický článek
MYC up-regulation confers vulnerability to dual inhibition of CDK12 and CDK13 in high-risk Group 3 medulloblastoma
Autor: Consuelo Pitolli, Alberto Marini, Marika Guerra, Marco Pieraccioli, Veronica Marabitti, Fernando Palluzzi, Luciano Giacò, Gianpiero Tamburrini, Francesco Cecconi, Francesca Nazio, Claudio Sette, Vittoria Pagliarini
Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-19 (2023)
Abstract Background Medulloblastoma (MB) is the most common cerebellar malignancy during childhood. Among MB, MYC-amplified Group 3 tumors display the worst prognosis. MYC is an oncogenic transcription factor currently thought to be undruggable. Neve
Externí odkaz: https://doaj.org/article/030743204b074a1299f471eeca329a4b
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3
Akademický článek
Fetal exposure to valproic acid dysregulates the expression of autism-linked genes in the developing cerebellum
Autor: Marika Guerra, Vanessa Medici, Robert Weatheritt, Valentina Corvino, Daniela Palacios, Maria Concetta Geloso, Donatella Farini, Claudio Sette
Publikováno v: Translational Psychiatry, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Autism spectrum disorder (ASD) includes a set of highly heritable neurodevelopmental syndromes characterized by social and communication impairment, repetitive behaviour, and intellectual disability. Although mutations in multiple genes have
Externí odkaz: https://doaj.org/article/94bd77eca8a84f9eb44c4d5f2629d607
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4
Akademický článek
Characterization of SOD1-DT, a Divergent Long Non-Coding RNA in the Locus of the SOD1 Human Gene
Autor: Marika Guerra, Lucia Meola, Serena Lattante, Amelia Conte, Mario Sabatelli, Claudio Sette, Camilla Bernardini
Publikováno v: Cells, Vol 12, Iss 16, p 2058 (2023)
Researchers studying Amyotrophic Lateral Sclerosis (ALS) have made significant efforts to find a unique mechanism to explain the etiopathology of the different forms of the disease. However, despite several mutations associated with ALS having been d
Externí odkaz: https://doaj.org/article/9bc3c348660a4baaa8d80e84bf62667a
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5
Akademický článek
A Dynamic Splicing Program Ensures Proper Synaptic Connections in the Developing Cerebellum
Autor: Donatella Farini, Eleonora Cesari, Robert J. Weatheritt, Gina La Sala, Chiara Naro, Vittoria Pagliarini, Davide Bonvissuto, Vanessa Medici, Marika Guerra, Chiara Di Pietro, Francesca Romana Rizzo, Alessandra Musella, Valeria Carola, Diego Centonze, Benjamin J. Blencowe, Daniela Marazziti, Claudio Sette
Publikováno v: Cell Reports, Vol 31, Iss 9, Pp - (2020)
Summary: Tight coordination of gene expression in the developing cerebellum is crucial for establishment of neuronal circuits governing motor and cognitive function. However, transcriptional changes alone do not explain all of the switches underlying
Externí odkaz: https://doaj.org/article/53d763ca94eb425fb47c36fc1b61d848
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6
Combined treatment with the histone deacetylase inhibitor LBH589 and a splice‐switch antisense oligonucleotide enhances SMN2 splicing and SMN expression in Spinal Muscular Atrophy cells
Autor: Vittoria Pagliarini, Claudio Sette, Marika Guerra, Claudia Compagnucci, Valentina Di Rosa
Publikováno v: Journal of Neurochemistry. 153:264-275
Spinal muscular atrophy (SMA) is a motor neuron disease caused by loss of function mutations in the Survival Motor Neuron 1 (SMN1) gene and reduced expression of the SMN protein, leading to spinal motor neuron death, muscle weakness and atrophy. Alth
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::777c091ac315ac01864a6fb0f775ed62
https://doi.org/10.1111/jnc.14935
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7
A Dynamic Splicing Program Ensures Proper Synaptic Connections in the Developing Cerebellum
Autor: Robert J. Weatheritt, Claudio Sette, Gina La Sala, Vanessa Medici, Francesca Romana Rizzo, Valeria Carola, Benjamin J. Blencowe, Marika Guerra, Vittoria Pagliarini, Chiara Naro, Davide Bonvissuto, Donatella Farini, Daniela Marazziti, Diego Centonze, Alessandra Musella, Eleonora Cesari, Chiara Di Pietro
Publikováno v: Cell reports 31 (2020). doi:10.1016/j.celrep.2020.107703
info:cnr-pdr/source/autori:Donatella Farini, Eleonora Cesari, Robert J. Weatheritt, Gina La Sala, Chiara Naro, Vittoria Pagliarini, Davide Bonvissuto, Vanessa Medici, Marika Guerra, Chiara Di Pietro, Francesca Romana Rizzo, Alessandra Musella, Valeria Carola, Diego Centonze, Benjamin J. Blencowe, Daniela Marazziti, Claudio Sette./titolo:A Dynamic Splicing Program Ensures Proper Synaptic Connections in the Developing Cerebellum/doi:10.1016%2Fj.celrep.2020.107703/rivista:Cell reports/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume:31
Cell Reports, Vol 31, Iss 9, Pp-(2020)
Summary Tight coordination of gene expression in the developing cerebellum is crucial for establishment of neuronal circuits governing motor and cognitive function. However, transcriptional changes alone do not explain all of the switches underlying
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc0c25922a1198d341d1a8788499a6ae
https://publications.cnr.it/doc/423270
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8
Akademický článek
Unravelling the Cerebellar Involvement in Autism Spectrum Disorders: Insights into Genetic Mechanisms and Developmental Pathways.
Autor: Guerra, Marika1 (AUTHOR) marika.guerra@unicatt.it, Medici, Vanessa1 (AUTHOR) vanessa.medici@guest.policlinicogemelli.it, La Sala, Gina2 (AUTHOR) gina.lasala@cnr.it, Farini, Donatella3 (AUTHOR) gina.lasala@cnr.it
Publikováno v: Cells (2073-4409). Jul2024, Vol. 13 Issue 14, p1176. 24p.
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9
Akademický článek
MYC up-regulation confers vulnerability to dual inhibition of CDK12 and CDK13 in high-risk Group 3 medulloblastoma.
Autor: Pitolli, Consuelo1 (AUTHOR), Marini, Alberto1,2 (AUTHOR), Guerra, Marika1 (AUTHOR), Pieraccioli, Marco1,2 (AUTHOR), Marabitti, Veronica3,4 (AUTHOR), Palluzzi, Fernando5,6 (AUTHOR), Giacò, Luciano5 (AUTHOR), Tamburrini, Gianpiero1,7 (AUTHOR), Cecconi, Francesco3,8,9 (AUTHOR), Nazio, Francesca3,4 (AUTHOR), Sette, Claudio1,2 (AUTHOR) claudio.sette@unicatt.it, Pagliarini, Vittoria1,2 (AUTHOR) vittoria.pagliarini@unicatt.it
Publikováno v: Journal of Experimental & Clinical Cancer Research (17569966). 11/21/2023, Vol. 42 Issue 1, p1-19. 19p.
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10
Akademický článek
Characterization of SOD1-DT, a Divergent Long Non-Coding RNA in the Locus of the SOD1 Human Gene.
Autor: Guerra, Marika1,2 (AUTHOR) lucia.meola1@unicatt.it, Meola, Lucia1 (AUTHOR) claudio.sette@unicatt.it, Lattante, Serena3 (AUTHOR) serena.lattante@unisalento.it, Conte, Amelia4 (AUTHOR) amelia.conte@centrocliniconemo.it, Sabatelli, Mario4,5 (AUTHOR) mario.sabatelli@unicatt.it, Sette, Claudio1,2 (AUTHOR), Bernardini, Camilla1 (AUTHOR) marika.guerra@unicatt.it
Publikováno v: Cells (2073-4409). Aug2023, Vol. 12 Issue 16, p2058. 15p.
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