Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Marika, Ruponen"'
Autor:
Sanni Peltonen, Tuuli-Maria Sonninen, Jonna Niskanen, Jari Koistinaho, Marika Ruponen, Šárka Lehtonen
Publikováno v:
Fluids and Barriers of the CNS, Vol 21, Iss 1, Pp 1-12 (2024)
Abstract Background Pericytes play a crucial role in controlling inflammation and vascular functions in the central nervous system, which are disrupted in Parkinson’s disease (PD). Still, there is a lack of studies on the impact of pericytes on neu
Externí odkaz:
https://doaj.org/article/40491bcb47914518b2652d7ebe326de0
Autor:
Rosamaria Lombardo, Marika Ruponen, Jarkko Rautio, Carla Ghelardini, Lorenzo Di Cesare Mannelli, Laura Calosi, Daniele Bani, Riikka Lampinen, Katja M. Kanninen, Anne M. Koivisto, Elina Penttilä, Heikki Löppönen, Rosario Pignatello
Publikováno v:
Pharmaceutics, Vol 15, Iss 5, p 1554 (2023)
Clozapine (CZP) is the only effective drug in schizophrenia resistant to typical antipsychotics. However, existing dosage forms (oral or orodispersible tablets, suspensions or intramuscular injection) show challenging limitations. After oral administ
Externí odkaz:
https://doaj.org/article/a9af83064787401fb31dedc14b1bfd1e
Autor:
Anusha Balla, Bao Tran, Annika Valtari, Philipp Steven, Camilla Scarpellini, Koen Augustyns, Arto Urtti, Kati-Sisko Vellonen, Marika Ruponen
Publikováno v:
Pharmaceutics, Vol 15, Iss 1, p 118 (2022)
Corneal wound, associated with pain, impaired vision, and even blindness, is the most common ocular injury. In this study, we investigated the effect of a novel ferroptosis inhibitor, UAMC-3203 (10 nM–50 µM), in corneal epithelial wound healing in
Externí odkaz:
https://doaj.org/article/d1136f4a281c4e77b6f05239a3ddcb2a
Autor:
Laura Hellinen, Heidi Hongisto, Eva Ramsay, Kai Kaarniranta, Kati-Sisko Vellonen, Heli Skottman, Marika Ruponen
Publikováno v:
Pharmaceutics, Vol 14, Iss 3, p 595 (2022)
The published article [...]
Externí odkaz:
https://doaj.org/article/fa8a6a9506b34194851652778e0765fe
Autor:
Charis Rousou, Josanne de Maar, Boning Qiu, Kim van der Wurff-Jacobs, Marika Ruponen, Arto Urtti, Sabrina Oliveira, Chrit Moonen, Gert Storm, Enrico Mastrobattista, Roel Deckers
Publikováno v:
Pharmaceutics, Vol 14, Iss 3, p 494 (2022)
The combination of ultrasound and microbubbles (USMB) has been applied to enhance drug permeability across tissue barriers. Most studies focused on only one physicochemical aspect (i.e., molecular weight of the delivered molecule). Using an in vitro
Externí odkaz:
https://doaj.org/article/617e21bbdeb14c44b399418198e81166
Autor:
Eva Kicková, Amir Sadeghi, Jooseppi Puranen, Shirin Tavakoli, Merve Sen, Veli-Pekka Ranta, Blanca Arango-Gonzalez, Sylvia Bolz, Marius Ueffing, Stefano Salmaso, Paolo Caliceti, Elisa Toropainen, Marika Ruponen, Arto Urtti
Publikováno v:
Pharmaceutics, Vol 14, Iss 1, p 12 (2021)
The treatment of retinal diseases by intravitreal injections requires frequent administration unless drug delivery systems with long retention and controlled release are used. In this work, we focused on pullulan (≈67 kDa) conjugates of dexamethaso
Externí odkaz:
https://doaj.org/article/612633861f1142a38420b60bad55386f
Autor:
Marco Bassetto, Daniel Ajoy, Florent Poulhes, Cathy Obringer, Aurelie Walter, Nadia Messadeq, Amir Sadeghi, Jooseppi Puranen, Marika Ruponen, Mikko Kettunen, Elisa Toropainen, Arto Urtti, Hélène Dollfus, Olivier Zelphati, Vincent Marion
Publikováno v:
Pharmaceutics, Vol 13, Iss 10, p 1650 (2021)
Barded-Biedl syndrome (BBS) is a rare genetic disorder with an unmet medical need for retinal degeneration. Small-molecule drugs were previously identified to slow down the apoptosis of photoreceptors in BBS mouse models. Clinical translation was not
Externí odkaz:
https://doaj.org/article/dcfef7fae1b1475e9c5cd6030b0df436
Autor:
Anusha Balla, Seppo Auriola, Angus C. Grey, Nicholas J. Demarais, Annika Valtari, Emma M. Heikkinen, Elisa Toropainen, Arto Urtti, Kati-Sisko Vellonen, Marika Ruponen
Publikováno v:
Pharmaceutics, Vol 13, Iss 5, p 658 (2021)
Ocular drug absorption after eye drop instillation has been widely studied, but partitioning phenomena and spatial drug distribution are poorly understood. We investigated partitioning of seven beta-blocking drugs in corneal epithelium, corneal strom
Externí odkaz:
https://doaj.org/article/162eda48723a475a9751d6954d92caef
Autor:
Elisa Toropainen, Sara J. Fraser-Miller, Dunja Novakovic, Eva M. Del Amo, Kati-Sisko Vellonen, Marika Ruponen, Tapani Viitala, Ossi Korhonen, Seppo Auriola, Laura Hellinen, Mika Reinisalo, Unni Tengvall, Stephanie Choi, Mohammad Absar, Clare Strachan, Arto Urtti
Publikováno v:
Pharmaceutics, Vol 13, Iss 4, p 452 (2021)
Eye drops of poorly soluble drugs are frequently formulated as suspensions. Bioavailability of suspended drug depends on the retention and dissolution of drug particles in the tear fluid, but these factors are still poorly understood. We investigated
Externí odkaz:
https://doaj.org/article/2af1e0b88b534519bb185694d6e37fe4
Autor:
Vijayabhaskarreddy Junnuthula, Amir Sadeghi Boroujeni, Shoupeng Cao, Shirin Tavakoli, Roxane Ridolfo, Elisa Toropainen, Marika Ruponen, Jan C. M. van Hest, Arto Urtti
Publikováno v:
Pharmaceutics, Vol 13, Iss 4, p 445 (2021)
Posterior eye tissues, such as retina, are affected in many serious eye diseases, but drug delivery to these targets is challenging due to various anatomical eye barriers. Intravitreal injections are widely used, but the intervals between invasive in
Externí odkaz:
https://doaj.org/article/5b4451b8b75c415c89a4c0dc5880d5fe