Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Marika, Franczak"'
Autor:
Barbara Kutryb-Zajac, Ada Kawecka, Alicja Braczko, Marika Franczak, Ewa M. Slominska, Roberto Giovannoni, Ryszard T. Smolenski
Publikováno v:
Biomedicines, Vol 10, Iss 7, p 1540 (2022)
Chronic hypoxia drives vascular dysfunction by various mechanisms, including changes in mitochondrial respiration. Although endothelial cells (ECs) rely predominantly on glycolysis, hypoxia is known to alter oxidative phosphorylation, promote oxidati
Externí odkaz:
https://doaj.org/article/f1ce3c754dac4508a64e0ab3cf00dab9
Autor:
Godefridus J. Peters, Marika Franczak, Isabel Toenshoff, Gerrit Jansen, Ryszard T. Smolenski, Elisa Giovannetti
Publikováno v:
Franczak, M, Toenshoff, I, Jansen, G, Smolenski, R T, Giovannetti, E & Peters, G J 2023, ' The Influence of Mitochondrial Energy and 1C Metabolism on the Efficacy of Anticancer Drugs : Exploring Potential Mechanisms of Resistance ', Current Medicinal Chemistry, vol. 30, no. 11, pp. 1209-1231 . https://doi.org/10.2174/0929867329666220401110418
Abstract: Mitochondria are the main energy factory in living cells. To rapidly proliferate and metastasize, neoplastic cells increase their energy requirements. Thus, mitochondria become one of the most important organelles for them. Indeed, much res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f40dbd51ebd58d66aad7162853300939
https://doi.org/10.2174/0929867329666220401110418
https://doi.org/10.2174/0929867329666220401110418
Autor:
Patrycja Jablonska, Paulina Mierzejewska, Marta Tomczyk, Patrycja Koszalka, Marika Franczak, Ada Kawecka, Barbara Kutryb-Zajac, Alicja Braczko, Ryszard T. Smolenski, Ewa M. Slominska
Publikováno v:
Biology, Vol 11, Iss 5, p 675 (2022)
The disruption of the metabolism of extracellular NAD+ and NMN may affect related signaling cascades and pathologies, such as cardiovascular or respiratory system diseases. We aimed to study NAD+ and NMN hydrolysis on surface endothelial cells of div
Externí odkaz:
https://doaj.org/article/57b5eb8fb0a64c7ba25decd71c3be461
Autor:
Caroline J.W. Meskers, Marika Franczak, Ryszard T. Smolenski, Elisa Giovannetti, Godefridus J. Peters
Publikováno v:
Meskers, C J W, Franczak, M, Smolenski, R T, Giovannetti, E & Peters, G J 2022, ' Are we still on the right path(way)? the altered expression of the pentose phosphate pathway in solid tumors and the potential of its inhibition in combination therapy ', Expert Opinion on Drug Metabolism and Toxicology, vol. 18, no. 1, pp. 61-83 . https://doi.org/10.1080/17425255.2022.2049234
Introduction: The pentose phosphate pathway (PPP) branches from glycolysis and is crucial for cell growth, since it provides necessary compounds for anabolic reactions, nucleotide synthesis, and detoxification of reactive-oxygen-species (ROS). Overex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a80617a6a46a22aa0a5195678a5c3cc4
http://www.scopus.com/inward/record.url?scp=85128062365&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85128062365&partnerID=8YFLogxK
Autor:
Klaudia Stawarska, Alicja Braczko, Ada Kawecka, Agata Jedrzejewska, Marzena Romanowska-Kocejko, Milena Deptula, Malgorzata Zawrzykraj, Marika Franczak, Oliwia Krol, Gabriela Harasim, Michal Pikula, Marcin Hellmann, Barbara Kutryb-Zajac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5cb0ad84b8e12fe7bd5e911e5c5b3ec2
https://doi.org/10.2139/ssrn.4443003
https://doi.org/10.2139/ssrn.4443003
Autor:
Annalisa Comandatore, Marika Franczak, Ryszard T. Smolenski, Luca Morelli, Godefridus J. Peters, Elisa Giovannetti
Publikováno v:
Comandatore, A, Franczak, M, Smolenski, R T, Morelli, L, Peters, G J & Giovannetti, E 2022, ' Lactate Dehydrogenase and its clinical significance in pancreatic and thoracic cancers ', Seminars in Cancer Biology, vol. 86, pp. 93-100 . https://doi.org/10.1016/j.semcancer.2022.09.001
The energy metabolism of tumor cells is considered one of the hallmarks of cancer because it is different from normal cells and mainly consists of aerobic glycolysis, fatty acid oxidation, and glutaminolysis. It is about one hundred years ago since W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbffd69adc411ad8662a2003aec46746
https://pubmed.ncbi.nlm.nih.gov/36096316
https://pubmed.ncbi.nlm.nih.gov/36096316
Autor:
Barbara, Kutryb-Zajac, Ada, Kawecka, Alicja, Braczko, Marika, Franczak, Ewa M, Slominska, Roberto, Giovannoni, Ryszard T, Smolenski
Publikováno v:
Biomedicines. 10(7)
Chronic hypoxia drives vascular dysfunction by various mechanisms, including changes in mitochondrial respiration. Although endothelial cells (ECs) rely predominantly on glycolysis, hypoxia is known to alter oxidative phosphorylation, promote oxidati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6890d7419106d5d5ae3ebba9a7cab532
https://pubmed.ncbi.nlm.nih.gov/35884844
https://pubmed.ncbi.nlm.nih.gov/35884844
Autor:
Valentina M. Gomez, Carlotta Granchi, Marika Franczak, Mjriam Capula, Ryszard T. Smolenski, Elisa Giovannetti, Filippo Minutolo, Christian M. Vonk, Btissame El Hassouni, Godefridus J. Peters
Publikováno v:
Oncoscience
Direct targeting of energy metabolism to defeat cancer is not a recent strategy. Although quite a few drugs use cellular metabolism for their antitumor effect, no direct inhibitors of energy metabolism have been approved by the FDA. Currently, severa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88ded1f424b854e27f722aa6ffd9fc6a
https://doi.org/10.18632/oncoscience.519
https://doi.org/10.18632/oncoscience.519
Autor:
Marika Franczak, Barbara Kutryb-Zajac, Btissame El Hassouni, Elisa Giovannetti, Carlotta Granchi, Filippo Minutolo, Ryszard T. Smolenski, Godefridus J. Peters
Publikováno v:
Franczak, M, Kutryb-Zajac, B, el Hassouni, B, Giovannetti, E, Granchi, C, Minutolo, F, Smolenski, R T & Peters, G J 2022, ' The effect of lactate dehydrogenase-A inhibition on intracellular nucleotides and mitochondrial respiration in pancreatic cancer cells ', Nucleosides, Nucleotides and Nucleic Acids, vol. 41, no. 12, pp. 1375-1385 . https://doi.org/10.1080/15257770.2022.2031215
Nucleosides, Nucleotides and Nucleic Acids, 41(12), 1375-1385. Taylor and Francis Ltd.
Nucleosides, Nucleotides and Nucleic Acids, 41(12), 1375-1385. Taylor and Francis Ltd.
Pancreatic cancer (PC) is one of the most lethal malignancies. PC is characterized by a high expression of the glucose transporter GLUT-1 and of lactate dehydrogenase A (LDH-A). The novel LDH-A inhibitor NHI-Glc-2 was designed for a better uptake via
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c167a0f8b2290a58c26475a4e26c4e5
https://research.vumc.nl/en/publications/01b8f746-f531-4e0e-9bfe-4f5280577ddf
https://research.vumc.nl/en/publications/01b8f746-f531-4e0e-9bfe-4f5280577ddf
Autor:
Dario P. Anobile, Giulia Montenovo, Camilla Pecoraro, Marika Franczak, Widad Ait Iddouch, Godefridus J Peters, Chiara Riganti, Elisa Giovannetti
Malignant mesothelioma (MMe) is an aggressive rare cancer of the mesothelium, associated with asbestos exposure. MMe is currently an incurable disease at all stages mainly due to resistance to treatments. It is therefore necessary to elucidate key me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27aded52754648f83036b752af4e1529
https://hdl.handle.net/2318/1885652
https://hdl.handle.net/2318/1885652