148 Primary or iPSC-derived cell-based cytotoxicity assays to assess potential safety risks of engineered T cell therapies in vitro

Autor: Gemma Moiset, Sophie Vermond, Monique Hazenoot, Rene McLaughlin, Sabrina de Munnik, Marco Guadagnoli, Sanne Holt, Marijn Vlaming

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)

Externí odkaz: https://doaj.org/article/d87669392ddd46b18ce37510d23d849f

149 In vitro efficacy studies to support engineered T cell therapies

Autor: Marco Guadagnoli, Monique Hazenoot, Gemma Moiset, Sann Holt, Sophie Vermond, Sabrina de Munnik, Rene McLaughlin, Marijn Vlaming

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)

BackgroundCell therapies such as Chimeric Antigen Receptor T cells (CAR-T) and T Cell Receptor (TCR) T cells are immune-therapeutic approaches showing great momentum in research and the clinic. To date, four anti-CD19 CAR-T products and one anti-BCMA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45983a689c0afa5573d6650161c84f87
https://doaj.org/article/ea383c9993774934b82c985557612dba

Abstract 294: In vitro efficacy studies to support engineered T cell therapies

Autor: Sophie Vermond, Marijn Vlaming, Marco Guadagnoli, Rene McLaughlin, Monique Hazenoot, Sanne Holt

Publikováno v: Cancer Research. 81:294-294

Cell therapies, such as Chimeric Antigen Receptor (CAR) and T Cell Receptor (TCR) T cells, are some of the latest immune-therapeutic approaches, showing great momentum in research and now the clinic. Only recently, two anti-CD19-CAR-T products have b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2bbce262b7b213bd20bba0975adac8ac
https://doi.org/10.1158/1538-7445.am2021-294

InPulse CrackIT Challenge: Development of An In Vitro Platform Using Physiologically Mature Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes to Screen for Drug-Induced Effects on Cardiac Contractility

Autor: Umber Saleem, Ljupcho Prodanov, Xiaoping Xu, Godfrey L. Smith, Marcelo C. Ribeiro, Robert Passier, Tessa de Korte, Diogo Mosqueira, Eric I. Rossman, Berend J. van Meer, Thomas Eschenhagen, Cathy Vickers, Stefan R. Braam, Leon G.J. Tertoolen, Christine L. Mummery, Chris Denning, Ingra Mannhardt, Victor Zamora Rodriguez, Maria Hortigon, Kate Harris, Karl S.A. Firth, Arne Hansen, Peter Clements, Marijn Vlaming, Vinoj George

Publikováno v: Journal of Pharmacological and Toxicological Methods, 88(2):0227, 238-238. Elsevier
Journal of Pharmacological and Toxicological Methods, 88, 238-238

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85a8af80e7a7196841a9bb68c299031d
https://research.utwente.nl/en/publications/inpulse-crackit-challenge-development-of-an-in-vitro-platform-using-physiologically-mature-human-induced-pluripotent-stem-cellderived-cardiomyocytes-to-screen-for-druginduced-effects-on-cardiac-contractility(2637840e-a1e7-4c9a-9261-668410be9aeb).html

Abstract C021: Validation of the interaction between a candidate compound and the intended drug target by a phenotypic rescue approach

Autor: Miranda van der Ham, Laure Grandmoursel, Armin Maier, Julia Schüler, Anne-Marie Zuurmond, Jamil Aarbiou, Ian D. Waddell, Geraldine Servant, Lieke Geerts, Jeroen DeGroot, Marijn Vlaming

Publikováno v: Molecular Cancer Therapeutics. 18:C021-C021

New targets for cancer treatment frequently emerge in literature, but the thorough target validation required to consider these targets for a drug discovery program is often lacking. In pharmacological or genetic perturbation studies using complex bi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::92ea5bc99bdd847689c560295d61edf5
https://doi.org/10.1158/1535-7163.targ-19-c021