Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Marijn Verkerk"'
Autor:
Thanh T. Hoang, Yunsung Lee, Daniel L. McCartney, Elin T.G. Kersten, Christian M. Page, Paige M. Hulls, Mikyeong Lee, Rosie M. Walker, Charles E. Breeze, Brian D. Bennett, Adam B. Burkholder, James Ward, Anne Lise Brantsæter, Ida H. Caspersen, Alison A. Motsinger-Reif, Marie Richards, Julie D. White, Shanshan Zhao, Rebecca C. Richmond, Maria C. Magnus, Gerard H. Koppelman, Kathryn L. Evans, Riccardo E. Marioni, Siri E. Håberg, Stephanie J. London, Bastiaan Heijmans, Peter ’t Hoen, Joyce van Meurs, Rick Jansen, Lude Franke, Dorret Boomsma, René Pool, Jenny van Dongen, Jouke Hottenga, Marleen van Greevenbroek, Coen Stehouwer, Carla van der Kallen, Casper Schalkwijk, Cisca Wijmenga, Sasha Zhernakova, Ettje Tigchelaar, P. Eline Slagboom, Marian Beekman, Joris Deelen, Diana Van Heemst, Jan Veldink, Leonard van den Berg, Cornelia van Duijn, Bert Hofman, Aaron Isaacs, André Uitterlinden, P. Mila Jhamai, Michael Verbiest, H. Eka Suchiman, Marijn Verkerk, Ruud van der Breggen, Jeroen van Rooij, Nico Lakenberg, Hailiang Mei, Maarten van Iterson, Michiel van Galen, Jan Bot, Dasha Zhernakova, Peter van ‘t Hof, Patrick Deelen, Irene Nooren, Matthijs Moed, Martijn Vermaat, René Luijk, Marc Bonder, Freerk van Dijk, Wibowo Arindrarto, Szymon Kielbasa, Morris Swertz, Erik van Zwet
Publikováno v:
EBioMedicine, Vol 100, Iss , Pp 104956- (2024)
Summary: Background: Smoking impacts DNA methylation, but data are lacking on smoking-related differential methylation by sex or dietary intake, recent smoking cessation (
Externí odkaz:
https://doaj.org/article/3985b627485b4ff999b2ec073dfaf4e4
Autor:
Anke R. Hammerschlag, Enda M. Byrne, Meike Bartels, Naomi R. Wray, Christel M. Middeldorp, Mawussé Agbessi, Habibul Ahsan, Isabel Alves, Anand Andiappan, Wibowo Arindrarto, Philip Awadalla, Alexis Battle, Frank Beutner, Marc Jan Bonder, Dorret I. Boomsma, Mark Christiansen, Annique Claringbould, Patrick Deelen, Tõnu Esko, Marie-Julie Favé, Lude Franke, Timothy Frayling, Sina A. Gharib, Gregory Gibson, Bastiaan T. Heijmans, Gibran Hemani, Rick Jansen, Mika Kähönen, Anette Kalnapenkis, Silva Kasela, Johannes Kettunen, Yungil Kim, Holger Kirsten, Peter Kovacs, Knut Krohn, Jaanika Kronberg-Guzman, Viktorija Kukushkina, Zoltan Kutalik, Bernett Lee, Terho Lehtimäki, Markus Loeffler, Urko M. Marigorta, Hailang Mei, Lili Milani, Grant W. Montgomery, Martina Müller-Nurasyid, Matthias Nauck, Michel Nivard, Brenda Penninx, Markus Perola, Natalia Pervjakova, Brandon L. Pierce, Joseph Powell, Holger Prokisch, Bruce M. Psaty, Olli T. Raitakari, Samuli Ripatti, Olaf Rotzschke, Sina Rüeger, Ashis Saha, Markus Scholz, Katharina Schramm, Ilkka Seppälä, Eline P. Slagboom, Coen D.A. Stehouwer, Michael Stumvoll, Patrick Sullivan, Peter A.C. ‘t Hoen, Alexander Teumer, Joachim Thiery, Lin Tong, Anke Tönjes, Jenny van Dongen, Maarten van Iterson, Joyce van Meurs, Jan H. Veldink, Joost Verlouw, Peter M. Visscher, Uwe Völker, Urmo Võsa, Harm-Jan Westra, Cisca Wijmenga, Hanieh Yaghootkar, Jian Yang, Biao Zeng, Futao Zhang, Aaron Isaacs, René Pool, Jouke J. Hottenga, Marleen MJ. van Greevenbroek, Carla J.H. van der Kallen, Casper G. Schalkwijk, Sasha Zhernakova, Ettje F. Tigchelaar, P. Eline Slagboom, Marian Beekman, Joris Deelen, Diana van Heemst, Leonard H. van den Berg, Cornelia M. van Duijn, Bert A. Hofman, André G. Uitterlinden, P. Mila Jhamai, Michael Verbiest, H.Eka D. Suchiman, Marijn Verkerk, Ruud van der Breggen, Jeroen van Rooij, Nico Lakenberg, Michiel van Galen, Jan Bot, Daria V. Zhernakova, Peter van ‘t Hof, Irene Nooren, Matthijs Moed, Martijn Vermaat, René Luijk, Freerk van Dijk, Szymon M. Kielbasa, Morris A. Swertz, Erik. W. van Zwet, Peter-Bram ‘t Hoen
Publikováno v:
Biological Psychiatry, 88(6), 470-479. Elsevier Science
Biological Psychiatry, 88(6), 470-479. Elsevier Inc.
eQTLGen Consortium & BIOS Consortium 2020, ' Refining Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder Genetic Loci by Integrating Summary Data From Genome-wide Association, Gene Expression, and DNA Methylation Studies ', Biological Psychiatry, vol. 88, no. 6, pp. 470-479 . https://doi.org/10.1016/j.biopsych.2020.05.002
Hammerschlag, A R, Byrne, E M, Bartels, M, Wray, N R, Middeldorp, C M, Agbessi, M, Ahsan, H, Alves, I, Andiappan, A, Arindrarto, W, Awadalla, P, Battle, A, Beutner, F, Bonder, M J, Christiansen, M, Claringbould, A, Deelen, P, Esko, T, Favé, M, Franke, L, Frayling, T, Gharib, S A, Gibson, G, Heijmans, B T, Hemani, G, Kähönen, M, Kalnapenkis, A, Kasela, S, Kettunen, J, Kim, Y, Kirsten, H, Kovacs, P, Krohn, K, Kronberg-guzman, J, Kukushkina, V, Kutalik, Z, Lee, B, Lehtimäki, T, Loeffler, M, Marigorta, U M, Mei, H, Milani, L, Montgomery, G W, Müller-nurasyid, M, Nauck, M, Nivard, M, Penninx, B, Perola, M, Pervjakova, N, Pierce, B L, Powell, J, Prokisch, H, Psaty, B M, Raitakari, O T, Ripatti, S, Rotzschke, O, Rüeger, S, Saha, A, Scholz, M, Schramm, K, Seppälä, I, Slagboom, P E, Stehouwer, C D A, Stumvoll, M, Sullivan, P, ‘t Hoen, P A C, Teumer, A, Thiery, J, Tong, L, Tönjes, A, Van Iterson, M, Van Meurs, J, Veldink, J H, Verlouw, J, Visscher, P M, Völker, U, Võsa, U, Westra, H, Wijmenga, C, Yaghootkar, H, Yang, J, Zeng, B, Zhang, F, Heijmans, B T, ‘t Hoen, P A C, Van Meurs, J, Isaacs, A, Franke, L, Pool, R, Van Dongen, J, Hottenga, J J, Van Greevenbroek, M M, Stehouwer, C D A, Van Der Kallen, C J H, Schalkwijk, C G, Wijmenga, C, Franke, L, Zhernakova, S, Tigchelaar, E F, Slagboom, P E, Beekman, M, Deelen, J, Van Heemst, D, Veldink, J H, Van Den Berg, L H, Van Duijn, C M, Hofman, B A, Isaacs, A, Uitterlinden, A G, Van Meurs, J, Jhamai, P M, Verbiest, M, Suchiman, H E D, Verkerk, M, Van Der Breggen, R, Van Rooij, J, Lakenberg, N, Van Iterson, M, Van Galen, M, Bot, J, Zhernakova, D V, Hof, P V, Deelen, P, Nooren, I, Heijmans, B T, Moed, M, Franke, L, Vermaat, M, Zhernakova, D V, Luijk, R, Bonder, M J, Van Iterson, M, Deelen, P, Van Dijk, F, Van Galen, M, Arindrarto, W, Kielbasa, S M, Swertz, M A, Van Zwet, E W, Hoen, P & Heijmans, B T 2020, ' Refining Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder Genetic Loci by Integrating Summary Data From Genome-wide Association, Gene Expression, and DNA Methylation Studies ', Biological Psychiatry, vol. 88, no. 6, pp. 470-479 . https://doi.org/10.1016/j.biopsych.2020.05.002
Biological Psychiatry, 88(6), 470-479. Elsevier USA
Biological Psychiatry, 88(6), 470-479. Elsevier Inc.
eQTLGen Consortium & BIOS Consortium 2020, ' Refining Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder Genetic Loci by Integrating Summary Data From Genome-wide Association, Gene Expression, and DNA Methylation Studies ', Biological Psychiatry, vol. 88, no. 6, pp. 470-479 . https://doi.org/10.1016/j.biopsych.2020.05.002
Hammerschlag, A R, Byrne, E M, Bartels, M, Wray, N R, Middeldorp, C M, Agbessi, M, Ahsan, H, Alves, I, Andiappan, A, Arindrarto, W, Awadalla, P, Battle, A, Beutner, F, Bonder, M J, Christiansen, M, Claringbould, A, Deelen, P, Esko, T, Favé, M, Franke, L, Frayling, T, Gharib, S A, Gibson, G, Heijmans, B T, Hemani, G, Kähönen, M, Kalnapenkis, A, Kasela, S, Kettunen, J, Kim, Y, Kirsten, H, Kovacs, P, Krohn, K, Kronberg-guzman, J, Kukushkina, V, Kutalik, Z, Lee, B, Lehtimäki, T, Loeffler, M, Marigorta, U M, Mei, H, Milani, L, Montgomery, G W, Müller-nurasyid, M, Nauck, M, Nivard, M, Penninx, B, Perola, M, Pervjakova, N, Pierce, B L, Powell, J, Prokisch, H, Psaty, B M, Raitakari, O T, Ripatti, S, Rotzschke, O, Rüeger, S, Saha, A, Scholz, M, Schramm, K, Seppälä, I, Slagboom, P E, Stehouwer, C D A, Stumvoll, M, Sullivan, P, ‘t Hoen, P A C, Teumer, A, Thiery, J, Tong, L, Tönjes, A, Van Iterson, M, Van Meurs, J, Veldink, J H, Verlouw, J, Visscher, P M, Völker, U, Võsa, U, Westra, H, Wijmenga, C, Yaghootkar, H, Yang, J, Zeng, B, Zhang, F, Heijmans, B T, ‘t Hoen, P A C, Van Meurs, J, Isaacs, A, Franke, L, Pool, R, Van Dongen, J, Hottenga, J J, Van Greevenbroek, M M, Stehouwer, C D A, Van Der Kallen, C J H, Schalkwijk, C G, Wijmenga, C, Franke, L, Zhernakova, S, Tigchelaar, E F, Slagboom, P E, Beekman, M, Deelen, J, Van Heemst, D, Veldink, J H, Van Den Berg, L H, Van Duijn, C M, Hofman, B A, Isaacs, A, Uitterlinden, A G, Van Meurs, J, Jhamai, P M, Verbiest, M, Suchiman, H E D, Verkerk, M, Van Der Breggen, R, Van Rooij, J, Lakenberg, N, Van Iterson, M, Van Galen, M, Bot, J, Zhernakova, D V, Hof, P V, Deelen, P, Nooren, I, Heijmans, B T, Moed, M, Franke, L, Vermaat, M, Zhernakova, D V, Luijk, R, Bonder, M J, Van Iterson, M, Deelen, P, Van Dijk, F, Van Galen, M, Arindrarto, W, Kielbasa, S M, Swertz, M A, Van Zwet, E W, Hoen, P & Heijmans, B T 2020, ' Refining Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder Genetic Loci by Integrating Summary Data From Genome-wide Association, Gene Expression, and DNA Methylation Studies ', Biological Psychiatry, vol. 88, no. 6, pp. 470-479 . https://doi.org/10.1016/j.biopsych.2020.05.002
Biological Psychiatry, 88(6), 470-479. Elsevier USA
BACKGROUND: Recent genome-wide association studies (GWASs) identified the first genetic loci associated with attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). The next step is to use these results to increase our und
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::669e44c703bba2705f5abf1f6858cc2a
https://cris.maastrichtuniversity.nl/en/publications/68c2431f-e6c5-4d88-b28b-9bb5be188928
https://cris.maastrichtuniversity.nl/en/publications/68c2431f-e6c5-4d88-b28b-9bb5be188928
Autor:
Jenny van Dongen, Nuno R. Zilhão, Karen Sugden, Eilis J. Hannon, Jonathan Mill, Avshalom Caspi, Jessica Agnew-Blais, Louise Arseneault, David L. Corcoran, Terrie E. Moffitt, Richie Poulton, Barbara Franke, Dorret I. Boomsma, Bastiaan T. Heijmans, Peter A.C. ’t Hoen, Joyce van Meurs, Aaron Isaacs, Rick Jansen, Lude Franke, René Pool, Jouke J. Hottenga, Marleen M.J. van Greevenbroek, Coen D.A. Stehouwer, Carla J.H. van der Kallen, Casper G. Schalkwijk, Cisca Wijmenga, Sasha Zhernakova, Ettje F. Tigchelaar, P. Eline Slagboom, Marian Beekman, Joris Deelen, Diana van Heemst, Jan H. Veldink, Leonard H. van den Berg, Cornelia M. van Duijn, Bert A. Hofman, André G. Uitterlinden, P. Mila Jhamai, Michael Verbiest, H. Eka D. Suchiman, Marijn Verkerk, Ruud van der Breggen, Jeroen van Rooij, Nico Lakenberg, Hailiang Mei, Maarten van Iterson, Michiel van Galen, Jan Bot, Dasha V. Zhernakova, Peter van ’t Hof, Patrick Deelen, Irene Nooren, Matthijs Moed, Martijn Vermaat, René Luijk, Marc Jan Bonder, Freerk van Dijk, Wibowo Arindrarto, Szymon M. Kielbasa, Morris A. Swertz, Erik. W. van Zwet, Peter-Bram ’t Hoen
Publikováno v:
Biological Psychiatry, 86(8), 599-607. Elsevier Inc.
Biological Psychiatry, 86(8), 599-607. ELSEVIER SCIENCE INC
Biological Psychiatry, 86(8), 599-607
Biological Psychiatry, 86(8), 599-607. Elsevier Science
Biological Psychiatry, 86(8), 599-607. Elsevier USA
van Dongen, J, Zilhão, N R, Sugden, K, Heijmans, B T, ’t Hoen, P A C, van Meurs, J, Isaacs, A, Jansen, R, Franke, L, Boomsma, D I, Pool, R, Hottenga, J J, van Greevenbroek, M M J, Stehouwer, C D A, van der Kallen, C J H, Schalkwijk, C G, Wijmenga, C, Zhernakova, S, Tigchelaar, E F, Slagboom, P E, Beekman, M, Deelen, J, van Heemst, D, Veldink, J H, van den Berg, L H, van Duijn, C M, Hofman, B A, Uitterlinden, A G, Jhamai, P M, Verbiest, M, Suchiman, H E D, Verkerk, M, van der Breggen, R, van Rooij, J, Lakenberg, N, Mei, H, van Iterson, M, van Galen, M, Bot, J, Zhernakova, D V, Hof, P V, Deelen, P, Nooren, I, Matthijs, M, Vermaat, M, Luijk, R, Bonder, M J, van Dijk, F, Arindrarto, W, Kielbasa, S M, BIOS Consortium, Kielbasa, S M, Swertz, M A, van Zwet, E W, ’t Hoen, P-B, Hannon, E, Mill, J, Caspi, A, Arseneault, L, Corcoran, D L, Moffitt, TE, Poulton, R, Franke, B & Boomsma, D I 2019, ' Epigenome-wide association study of Attention-Deficit/Hyperactivity Disorder symptoms in adults ', Biological Psychiatry, vol. 86, no. 8, pp. 599-607 . https://doi.org/10.1016/j.biopsych.2019.02.016
Biological Psychiatry, 86, 599-607
Biological Psychiatry, 86, 8, pp. 599-607
van Dongen, J, Zilhão, N R, Sugden, K, Hannon, E J, Mill, J, Caspi, A, Agnew-Blais, J, Arseneault, L, Corcoran, D L, Moffitt, T E, Poulton, R, Franke, B, Boomsma, D I & BIOS Consortium 2019, ' Epigenome-wide Association Study of Attention-Deficit/Hyperactivity Disorder Symptoms in Adults ', Biological Psychiatry, vol. 86, no. 8, pp. 599-607 . https://doi.org/10.1016/j.biopsych.2019.02.016
Biological Psychiatry, 86(8), 599-607. ELSEVIER SCIENCE INC
Biological Psychiatry, 86(8), 599-607
Biological Psychiatry, 86(8), 599-607. Elsevier Science
Biological Psychiatry, 86(8), 599-607. Elsevier USA
van Dongen, J, Zilhão, N R, Sugden, K, Heijmans, B T, ’t Hoen, P A C, van Meurs, J, Isaacs, A, Jansen, R, Franke, L, Boomsma, D I, Pool, R, Hottenga, J J, van Greevenbroek, M M J, Stehouwer, C D A, van der Kallen, C J H, Schalkwijk, C G, Wijmenga, C, Zhernakova, S, Tigchelaar, E F, Slagboom, P E, Beekman, M, Deelen, J, van Heemst, D, Veldink, J H, van den Berg, L H, van Duijn, C M, Hofman, B A, Uitterlinden, A G, Jhamai, P M, Verbiest, M, Suchiman, H E D, Verkerk, M, van der Breggen, R, van Rooij, J, Lakenberg, N, Mei, H, van Iterson, M, van Galen, M, Bot, J, Zhernakova, D V, Hof, P V, Deelen, P, Nooren, I, Matthijs, M, Vermaat, M, Luijk, R, Bonder, M J, van Dijk, F, Arindrarto, W, Kielbasa, S M, BIOS Consortium, Kielbasa, S M, Swertz, M A, van Zwet, E W, ’t Hoen, P-B, Hannon, E, Mill, J, Caspi, A, Arseneault, L, Corcoran, D L, Moffitt, TE, Poulton, R, Franke, B & Boomsma, D I 2019, ' Epigenome-wide association study of Attention-Deficit/Hyperactivity Disorder symptoms in adults ', Biological Psychiatry, vol. 86, no. 8, pp. 599-607 . https://doi.org/10.1016/j.biopsych.2019.02.016
Biological Psychiatry, 86, 599-607
Biological Psychiatry, 86, 8, pp. 599-607
van Dongen, J, Zilhão, N R, Sugden, K, Hannon, E J, Mill, J, Caspi, A, Agnew-Blais, J, Arseneault, L, Corcoran, D L, Moffitt, T E, Poulton, R, Franke, B, Boomsma, D I & BIOS Consortium 2019, ' Epigenome-wide Association Study of Attention-Deficit/Hyperactivity Disorder Symptoms in Adults ', Biological Psychiatry, vol. 86, no. 8, pp. 599-607 . https://doi.org/10.1016/j.biopsych.2019.02.016
Contains fulltext : 209008.pdf (Publisher’s version ) (Open Access) BACKGROUND: Previous studies have reported associations between attention-deficit/hyperactivity disorder symptoms and DNA methylation in children. We report the first epigenome-wid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11873a019ce25df0fa87e8d37a996e29
https://pure.eur.nl/en/publications/67b92a1a-561a-42ea-8fae-6f9d8cb68e2c
https://pure.eur.nl/en/publications/67b92a1a-561a-42ea-8fae-6f9d8cb68e2c
Autor:
Isis Ricaño-Ponce, Daria V. Zhernakova, Patrick Deelen, Oscar Luo, Xingwang Li, Aaron Isaacs, Juha Karjalainen, Jennifer Di Tommaso, Zuzanna Agnieszka Borek, Maria M. Zorro, Javier Gutierrez-Achury, Andre G. Uitterlinden, Albert Hofman, Joyce van Meurs, Mihai G. Netea, Iris H. Jonkers, Sebo Withoff, Cornelia M. van Duijn, Yang Li, Yijun Ruan, Lude Franke, Cisca Wijmenga, Vinod Kumar, Bastiaan T. Heijmans, Peter A.C. 't Hoen, Rick Jansen, Dorret I. Boomsma, René Pool, Jenny van Dongen, Jouke J. Hottenga, Marleen M.J. van Greevenbroek, Coen D.A. Stehouwer, Carla J.H. van der Kallen, Casper G. Schalkwijk, Alexandra Zhernakova, Ettje F. Tigchelaar, P. Eline Slagboom, Marian Beekman, Joris Deelen, Diana van Heemst, Jan H. Veldink, Leonard H. van den Berg, Bert A. Hofman, André G. Uitterlinden, P. Mila Jhamai, Michael Verbiest, H. Eka D. Suchiman, Marijn Verkerk, Ruud van der Breggen, Jeroen van Rooij, Nico Lakenberg, Hailiang Mei, Maarten van Iterson, Michiel van Galen, Jan Bot, Peter van 't Hof, Irene Nooren, Matthijs Moed, Martijn Vermaat, René Luijk, Marc Jan Bonder, Freerk van Dijk, Wibowo Arindrarto, Szymon M. Kielbasa, Morris A. Swertz, Erik W. van Zwet
Publikováno v:
Journal of Autoimmunity, 68, 62-74. Academic Press Inc.
Journal of Autoimmunity, 68, pp. 62-74
Journal of Autoimmunity, 68, 62-74. Elsevier Science
Journal of Autoimmunity, 68, 62-74
Journal of autoimmunity
Journal of Autoimmunity, 68, 62-74. ACADEMIC PRESS LTD-ELSEVIER SCIENCE LTD
Journal of Autoimmunity, 68, 62-74. Academic Press
Ricano-Ponce, I, Zhernakova, D V, Deelen, P, Luo, O, Li, X, Isaacs, A, Karjalainen, J, Di. Tommaso, J, Borek, Z A, Zorro, M M, Gutierrez-Achury, J, Uitterlinden, A G, Hofman, A, van Meurs, J, Boomsma, D I, Pool, R, van Dongen, J, Hottenga, J J, Neteaf, M G, Jonkers, I H, Withoff, S, van Duijn, C M, Li, Y, Ruan, Y, Franke, L, Wijmenga, C & Kumar, V 2016, ' Refined mapping of autoimmune disease associated genetic variants with gene expression suggests an important role for non-coding RNAs ', Journal of Autoimmunity, vol. 68, pp. 62-74 . https://doi.org/10.1016/j.jaut.2016.01.002
Journal of Autoimmunity, 68, pp. 62-74
Journal of Autoimmunity, 68, 62-74. Elsevier Science
Journal of Autoimmunity, 68, 62-74
Journal of autoimmunity
Journal of Autoimmunity, 68, 62-74. ACADEMIC PRESS LTD-ELSEVIER SCIENCE LTD
Journal of Autoimmunity, 68, 62-74. Academic Press
Ricano-Ponce, I, Zhernakova, D V, Deelen, P, Luo, O, Li, X, Isaacs, A, Karjalainen, J, Di. Tommaso, J, Borek, Z A, Zorro, M M, Gutierrez-Achury, J, Uitterlinden, A G, Hofman, A, van Meurs, J, Boomsma, D I, Pool, R, van Dongen, J, Hottenga, J J, Neteaf, M G, Jonkers, I H, Withoff, S, van Duijn, C M, Li, Y, Ruan, Y, Franke, L, Wijmenga, C & Kumar, V 2016, ' Refined mapping of autoimmune disease associated genetic variants with gene expression suggests an important role for non-coding RNAs ', Journal of Autoimmunity, vol. 68, pp. 62-74 . https://doi.org/10.1016/j.jaut.2016.01.002
Contains fulltext : 171367.pdf (Publisher’s version ) (Open Access) Genome-wide association and fine-mapping studies in 14 autoimmune diseases (AID) have implicated more than 250 loci in one or more of these diseases. As more than 90% of AID-associ
Autor:
Robert Kraaij, Albert Hofman, Mila Jhamai, Marijn Verkerk, M. Arfan Ikram, Jeroen van Rooij, Stephan C A Nouwens, Fernando Rivadeneira, Joyce B. J. van Meurs, Pascal P. Arp, Annemieke J.M.H. Verkerk, André G. Uitterlinden
Publikováno v:
European Journal of Human Genetics, 25(10), 1173-1175. Nature Publishing Group
We have generated a next-generation whole-exome sequencing data set of 2628 participants of the population-based Rotterdam Study cohort, comprising 669 737 single-nucleotide variants and 24 019 short insertions and deletions. Because of broad and dee
Autor:
Marleen M.J. van Greevenbroek, Erik W. van Zwet, Jeroen van Rooij, Wibowo Arindrarto, Tianxiao Huan, Marijn Verkerk, Allan C. Just, Cisca Wijmenga, Coen D.A. Stehouwer, Cornelia M. van Duijn, Coleen M. Damcott, Symen Ligthart, Dorret I. Boomsma, Cristina Menni, Hailiang Mei, Guosheng Zhang, Eric Boerwinkle, Diana van Heemst, Albert Hofman, Casper G. Schalkwijk, Jordana T. Bell, Carla J.H. van der Kallen, John M. Starr, Yucheng Jia, Andrea A. Baccarelli, Jeffrey R. O'Connell, Joyce B. C van Meurs, Steve Horvath, Allan F. McRae, Leonard H. van den Berg, Walter Palmas, Szymon M. Kielbasa, Freerk van Dijk, Stephen Turner, Sharon L.R. Kardia, Donna K. Arnett, Devin Absher, James D. Stewart, Jerome I. Rotter, Jouke J. Hottenga, Rahul Gondalia, Jan Bot, Joris Deelen, René Pool, Tomáš Paus, Yii-Der Ida Chen, Peter A.C. ’t Hoen, Thomas H. Mosley, René Luijk, Zdenka Pausova, Ettje F. Tigchelaar, Bastiaan T. Heijmans, André G. Uitterlinden, P. Mila Jhamai, Eric A. Whitsel, Alanna C. Morrison, Patrick Deelen, Lude Franke, Riccardo E. Marioni, Chunyu Liu, Rick Jansen, Marc Jan Bonder, J. H. Veldink, Xiuqing Guo, Oscar H. Franco, Yongmei Liu, Nona Sotoodehnia, Nico Lakenberg, Joel Schwartz, Daniel Levy, Catriona Syme, May E. Montasser, Irene Nooren, Elias Salfati, Michael M. Mendelson, Abbas Dehghan, Tim D. Spector, Jan Bressler, Jennifer A. Smith, Matthijs Moed, H. Eka D. Suchiman, Martijn Vermaat, Alan R. Shuldiner, Michael M. P. J. Verbiest, A Isaacs, Dasha V. Zhernakova, Jennifer A. Brody, Alexandra Zhernakova, Wei Zhao, Marian Beekman, Ian J. Deary, Maarten van Iterson, Min A. Jhun, Michiel van Galen, Weihua Guan, Jincheng Shen, Stella Aslibekyan, Myriam Fornage, Joyce B. J. van Meurs, Pantel S. Vokonas, Bruce M. Psaty, Melissa A. Richard, Peter Van ‘t Hof, Yun Li, Morris A. Swertz, Themistocles L. Assimes, P. Eline Slagboom, Jenny van Dongen, Pei-Chien Tsai, Lifang Hou, Ruud van der Breggen, Marguerite R. Irvin, Joshua C. Bis
Publikováno v:
Richard, M A, Huan, T, Ligthart, S, Gondalia, R, Jhun, M A, Brody, J A, Irvin, M R, Marioni, R, Shen, J, Tsai, P-C, Montasser, M E, Jia, Y, Syme, C, Salfati, E L, Boerwinkle, E, Guan, W, Mosley, T H, Bressler, J, Morrison, A C, Liu, C, Mendelson, M M, Uitterlinden, A G, van Meurs, J B, Franco, O H, Zhang, G, Li, Y, Stewart, J D, Bis, J C, Psaty, B M, Chen, Y-D I, Kardia, S L R, Zhao, W, Turner, S T, Absher, D, Aslibekyan, S, Starr, J M, McRae, A F, Hou, L, Just, A C, Schwartz, J D, Vokonas, P S, Menni, C, Spector, T D, Shuldiner, A, Damcott, C M, Rotter, J I, BIOS Consortium, Boomsma, D I, Pool, R, van Dongen, J & Hottenga, J J 2017, ' DNA Methylation Analysis Identifies Loci for Blood Pressure Regulation ', American Journal of Human Genetics, vol. 101, no. 6, pp. 888-902 . https://doi.org/10.1016/j.ajhg.2017.09.028
American Journal of Human Genetics, 101(6), 888-902. Cell Press
American journal of human genetics, vol 101, iss 6
American Journal of Human Genetics, 101(6), 888-902
Richard, M A, Huan, T, Ligthart, S, Gondalia, R, Jhun, M A, Brody, J A, Irvin, M R, Marioni, R, Shen, J, Tsai, P-C, Montasser, M E, Jia, Y, Syme, C, Salfati, E L, Boerwinkle, E, Guan, W, Mosley, T H, Bressler, J, Morrison, A C, Liu, C, Mendelson, M M, Uitterlinden, A G, van Meurs, J B, Franco, O H, Zhang, G, Li, Y, Stewart, J D, Bis, J C, Psaty, B M, Chen, Y-D I, Kardia, S L R, Zhao, W, Turner, S T, Absher, D, Aslibekyan, S, Starr, J M, McRae, A F, Hou, L, Just, A C, Schwartz, J D, Vokonas, P S, Menni, C, Spector, T D, Shuldiner, A, Damcott, C M, Rotter, J I, Palmas, W, Liu, Y & Smith, J A & Deary, I J 2017, ' DNA methylation analysis identifies loci for blood pressure regulation ', American Journal of Human Genetics, vol. 101, no. 6, pp. 888-902 . https://doi.org/10.1016/j.ajhg.2017.09.028
American Journal of Human Genetics, 101(6), 888-902. Cell Press
American journal of human genetics, vol 101, iss 6
American Journal of Human Genetics, 101(6), 888-902
Richard, M A, Huan, T, Ligthart, S, Gondalia, R, Jhun, M A, Brody, J A, Irvin, M R, Marioni, R, Shen, J, Tsai, P-C, Montasser, M E, Jia, Y, Syme, C, Salfati, E L, Boerwinkle, E, Guan, W, Mosley, T H, Bressler, J, Morrison, A C, Liu, C, Mendelson, M M, Uitterlinden, A G, van Meurs, J B, Franco, O H, Zhang, G, Li, Y, Stewart, J D, Bis, J C, Psaty, B M, Chen, Y-D I, Kardia, S L R, Zhao, W, Turner, S T, Absher, D, Aslibekyan, S, Starr, J M, McRae, A F, Hou, L, Just, A C, Schwartz, J D, Vokonas, P S, Menni, C, Spector, T D, Shuldiner, A, Damcott, C M, Rotter, J I, Palmas, W, Liu, Y & Smith, J A & Deary, I J 2017, ' DNA methylation analysis identifies loci for blood pressure regulation ', American Journal of Human Genetics, vol. 101, no. 6, pp. 888-902 . https://doi.org/10.1016/j.ajhg.2017.09.028
Genome-wide association studies have identified hundreds of genetic variants associated with blood pressure (BP), but sequence variation accounts for a small fraction of the phenotypic variance. Epigenetic changes may alter the expression of genes in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91f9a42b3b8c7e77be3a72983127a651
https://hdl.handle.net/1871.1/51b0b3db-be77-422d-8855-2ee913d5b802
https://hdl.handle.net/1871.1/51b0b3db-be77-422d-8855-2ee913d5b802
Autor:
Peter Van ‘t Hof, Erik W. van Zwet, Matthijs Moed, Jeroen van Rooij, Joris Deelen, Freerk van Dijk, Nico Lakenberg, Cisca Wijmenga, André G. Uitterlinden, Rick Jansen, Maarten van Iterson, Dasha V. Zhernakova, Szymon M. Kielbasa, Martijn Vermaat, Marleen J. van Greevenbroek, Hailiang Mei, Cornelia M. van Duijn, René Pool, Jan Bot, Lude Franke, Sasha Zhernakova, Michiel van Galen, H. Eka D. Suchiman, Morris A. Swertz, Marc Jan Bonder, Bert A. Hofman, Wibowo Arindrarto, Joyce B. J. van Meurs, Jouke J. Hottenga, Coen D.A. Stehouwer, Jenny van Dongen, Michael M. P. J. Verbiest, René Luijk, P. Eline Slagboom, Patrick Deelen, Dorret I. Boomsma, Jan H. Veldink, Leonard H. van den Berg, Diana van Heemst, Aaron Isaacs, Marijn Verkerk, Peter A C 't Hoen, Ruud van der Breggen, Casper G. Schalkwijk, Ettje F. Tigchelaar, Peter Bram 't Hoen, Marian Beekman, Carla J.H. van der Kallen, Bastiaan T. Heijmans, P. Mila Jhamai, Irene Nooren
Publikováno v:
Genome Biology, 18(1):19. Springer Verlag
Genome Biology, 18(1):19. BioMed Central Ltd.
van Iterson, M, van Zwet, E W, Heijmans, B T, ’t Hoen, P A C, van Meurs, J B J, Jansen, R, Franke, L, Boomsma, D I, Pool, R, van Dongen, J, Hottenga, J J, Van Greevenbroek, M J, Stehouwer, C D A, van der Kallen, C J H, Schalkwijk, C G, Wijmenga, C, Zhernakova, S, Tigchelaar, E F, Eline Slagboom, P, Beekman, M, Deelen, J, van Heemst, D, Veldink, J H, van den Berg, L H, van Duijn, C M, Hofman, B A, Isaacs, A, Uitterlinden, A G, Jhamai, P M, Verbiest, M, Suchiman, H E D, Verkerk, M, van der Breggen, R, van Rooij, J, Lakenberg, N, Mei, H, van Galen, M, Bot, J, Zhernakova, D V, van 't Hof, P, Deelen, P, Nooren, I, Moed, M, Vermaat, M, Luijk, R, Bonder, M J, van Dijk, F, Arindrarto, W, Kielbasa, S M, Swertz, M A & 't Hoen, P B 2017, ' Controlling bias and inflation in epigenome-and transcriptome-wide association studies using the empirical null distribution ', Genome Biology, vol. 18, no. 1, 19 . https://doi.org/10.1186/s13059-016-1131-9
Genome Biology, 18
van Iterson, M, van Zwet, E W, Heijmans, B T, 't Hoen, P A C, van Meurs, J, Jansen, R, Franke, L, Boomsma, D I, Pool, R, van Dongen, J, Hottenga, J J, van Greevenbroek, M M J, Stehouwer, C D A, van der Kallen, C J H, Schalkwijk, C G, Wijmenga, C, Zhernakova, S, Tigchelaar, E F, Eline Slagboom, P, Beekman, M, Deelen, J, van Heemst, D, Veldink, J H, van den Berg, L H, van Duijn, C M, Hofman, B A, Isaacs, A, Uitterlinden, A G, Jhamai, P M, Verbiest, M, Suchiman, H E D, Verkerk, M, van der Breggen, R, van Rooij, J, Lakenberg, N, Mei, H, van Galen, M, Bot, J, Zhernakova, D V, van 't Hof, P, Deelen, P, Nooren, I, Moed, M, Vermaat, M, Luijk, R, Bonder, M J, van Dijk, F, Arindrarto, W, Kielbasa, S M, Swertz, M A & 't Hoen, P B 2017, ' Controlling bias and inflation in epigenome-and transcriptome-wide association studies using the empirical null distribution ', Genome Biology, vol. 18, no. 1, 19 . https://doi.org/10.1186/s13059-016-1131-9
Genome Biology
Genome Biology, 18(1):19. BioMed Central Ltd.
van Iterson, M, van Zwet, E W, Heijmans, B T, ’t Hoen, P A C, van Meurs, J B J, Jansen, R, Franke, L, Boomsma, D I, Pool, R, van Dongen, J, Hottenga, J J, Van Greevenbroek, M J, Stehouwer, C D A, van der Kallen, C J H, Schalkwijk, C G, Wijmenga, C, Zhernakova, S, Tigchelaar, E F, Eline Slagboom, P, Beekman, M, Deelen, J, van Heemst, D, Veldink, J H, van den Berg, L H, van Duijn, C M, Hofman, B A, Isaacs, A, Uitterlinden, A G, Jhamai, P M, Verbiest, M, Suchiman, H E D, Verkerk, M, van der Breggen, R, van Rooij, J, Lakenberg, N, Mei, H, van Galen, M, Bot, J, Zhernakova, D V, van 't Hof, P, Deelen, P, Nooren, I, Moed, M, Vermaat, M, Luijk, R, Bonder, M J, van Dijk, F, Arindrarto, W, Kielbasa, S M, Swertz, M A & 't Hoen, P B 2017, ' Controlling bias and inflation in epigenome-and transcriptome-wide association studies using the empirical null distribution ', Genome Biology, vol. 18, no. 1, 19 . https://doi.org/10.1186/s13059-016-1131-9
Genome Biology, 18
van Iterson, M, van Zwet, E W, Heijmans, B T, 't Hoen, P A C, van Meurs, J, Jansen, R, Franke, L, Boomsma, D I, Pool, R, van Dongen, J, Hottenga, J J, van Greevenbroek, M M J, Stehouwer, C D A, van der Kallen, C J H, Schalkwijk, C G, Wijmenga, C, Zhernakova, S, Tigchelaar, E F, Eline Slagboom, P, Beekman, M, Deelen, J, van Heemst, D, Veldink, J H, van den Berg, L H, van Duijn, C M, Hofman, B A, Isaacs, A, Uitterlinden, A G, Jhamai, P M, Verbiest, M, Suchiman, H E D, Verkerk, M, van der Breggen, R, van Rooij, J, Lakenberg, N, Mei, H, van Galen, M, Bot, J, Zhernakova, D V, van 't Hof, P, Deelen, P, Nooren, I, Moed, M, Vermaat, M, Luijk, R, Bonder, M J, van Dijk, F, Arindrarto, W, Kielbasa, S M, Swertz, M A & 't Hoen, P B 2017, ' Controlling bias and inflation in epigenome-and transcriptome-wide association studies using the empirical null distribution ', Genome Biology, vol. 18, no. 1, 19 . https://doi.org/10.1186/s13059-016-1131-9
Genome Biology
We show that epigenome- and transcriptome-wide association studies (EWAS and TWAS) are prone to significant inflation and bias of test statistics, an unrecognized phenomenon introducing spurious findings if left unaddressed. Neither GWAS-based method
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75c64cec6e93f81a6586330768430c9b
https://hdl.handle.net/1887/114294
https://hdl.handle.net/1887/114294
Autor:
Cornelia M. van Duijn, H. Eka D. Suchiman, Hailiang Mei, Bastiaan T. Heijmans, Michiel van Galen, Wibowo Arindrarto, Daria V. Zhernakova, Peter A C 't Hoen, Coen D.A. Stehouwer, Cisca Wijmenga, Erik W. van Zwet, Peter van ‘t Hof, Albert Hofman, Yang Li, Marian Beekman, Carla J.H. van der Kallen, P. Eline Slagboom, Joris Deelen, Szymon M. Kielbasa, Jouke J. Hottenga, Alexandra Zhernakova, René Luijk, Aaron Isaacs, Diana van Heemst, Jeroen van Rooij, P. Mila Jhamai, Irene Nooren, Iris Jonkers, Leonard H. van den Berg, René Pool, André G. Uitterlinden, Jenny van Dongen, Casper G. Schalkwijk, Lude Franke, Morris A. Swertz, Marc Jan Bonder, Nico Lakenberg, Marijn Verkerk, Rick Jansen, Michael Verbiest, Patrick Deelen, Mathieu Lemire, Ettje F. Tigchelaar, Thomas J. Hudson, Martijn Vermaat, Matthijs Moed, Jan H. Veldink, Roderick C. Slieker, Marleen M.J. van Greevenbroek, Jan Bot, Joyce B. J. van Meurs, Ruud van der Breggen, Maarten van Iterson, Dorret I. Boomsma, Freerk van Dijk
Publikováno v:
Nature Genetics, 49(1), 131-138. Nature Publishing Group
Nature Genetics, 49(1), 131–138. Nature Publishing Group
Bonder, M J, Luijk, R, Zhernakova, D V, Moed, M, Deelen, P, Vermaat, M, van Iterson, M, van Dijk, F, van Galen, M, Bot, J, Slieker, R C, Jhamai, P M, Verbiest, M, Suchiman, H E D, Verkerk, M, van der Breggen, R, van Rooij, J, Lakenberg, N, Arindrarto, W, Kielbasa, S M, Jonkers, I, van 't Hof, P, Nooren, I, Beekman, M, Deelen, J, van Heemst, D, Zhernakova, A, Tigchelaar, E F, Swertz, M A, Hofman, A, Uitterlinden, A G, Pool, R, van Dongen, J, Hottenga, J J, Stehouwer, C D A, van der Kallen, C J H, Schalkwijk, C G, van den Berg, L H, van Zwet, E W, Mei, H, Li, Y, Lemire, M, Hudson, T J, Slagboom, P E, Wijmenga, C, Veldink, J H, Van Greevenbroek, M J, van Duijn, C M, Boomsma, D I, Isaacs, A & BIOS Consortium 2017, ' Disease variants alter transcription factor levels and methylation of their binding sites ', Nature Genetics, vol. 49, no. 1, pp. 131-138 . https://doi.org/10.1038/ng.3721
Nat Genet
Nature Genetics, 49(1), 131-138
Bonder, M J, Luijk, R, Zhernakova, D V, Moed, M, Deelen, P, Vermaat, M, Van Iterson, M, Van Dijk, F, Van Galen, M, Bot, J, Slieker, R C, Jhamai, P M, Verbiest, M, Suchiman, H E D, Verkerk, M, Van Der Breggen, R, Van Rooij, J, Lakenberg, N, Arindrarto, W, Kielbasa, S M, Jonkers, I, Van't Hof, P, Nooren, I, Beekman, M, Deelen, J, Van Heemst, D, Zhernakova, A, Tigchelaar, E F, Swertz, M A, Hofman, A, Uitterlinden, A G, Pool, R, Van Dongen, J, Hottenga, J J, Stehouwer, C D A, Van Der Kallen, C J H, Schalkwijk, C G, Van Den Berg, L H, Van Zwet, E W, Mei, H, Li, Y, Lemire, M, Hudson, T J, Slagboom, P E, Wijmenga, C, Veldink, J H, Van Greevenbroek, M M J, Van Duijn, C M, Boomsma, D I, Jansen, R & the BIOS Consortium 2017, ' Disease variants alter transcription factor levels and methylation of their binding sites ', Nature Genetics, vol. 49, no. 1, pp. 131-138 . https://doi.org/10.1038/ng.3721
Nature Genetics, 49(1), 131–138. Nature Publishing Group
Bonder, M J, Luijk, R, Zhernakova, D V, Moed, M, Deelen, P, Vermaat, M, van Iterson, M, van Dijk, F, van Galen, M, Bot, J, Slieker, R C, Jhamai, P M, Verbiest, M, Suchiman, H E D, Verkerk, M, van der Breggen, R, van Rooij, J, Lakenberg, N, Arindrarto, W, Kielbasa, S M, Jonkers, I, van 't Hof, P, Nooren, I, Beekman, M, Deelen, J, van Heemst, D, Zhernakova, A, Tigchelaar, E F, Swertz, M A, Hofman, A, Uitterlinden, A G, Pool, R, van Dongen, J, Hottenga, J J, Stehouwer, C D A, van der Kallen, C J H, Schalkwijk, C G, van den Berg, L H, van Zwet, E W, Mei, H, Li, Y, Lemire, M, Hudson, T J, Slagboom, P E, Wijmenga, C, Veldink, J H, Van Greevenbroek, M J, van Duijn, C M, Boomsma, D I, Isaacs, A & BIOS Consortium 2017, ' Disease variants alter transcription factor levels and methylation of their binding sites ', Nature Genetics, vol. 49, no. 1, pp. 131-138 . https://doi.org/10.1038/ng.3721
Nat Genet
Nature Genetics, 49(1), 131-138
Bonder, M J, Luijk, R, Zhernakova, D V, Moed, M, Deelen, P, Vermaat, M, Van Iterson, M, Van Dijk, F, Van Galen, M, Bot, J, Slieker, R C, Jhamai, P M, Verbiest, M, Suchiman, H E D, Verkerk, M, Van Der Breggen, R, Van Rooij, J, Lakenberg, N, Arindrarto, W, Kielbasa, S M, Jonkers, I, Van't Hof, P, Nooren, I, Beekman, M, Deelen, J, Van Heemst, D, Zhernakova, A, Tigchelaar, E F, Swertz, M A, Hofman, A, Uitterlinden, A G, Pool, R, Van Dongen, J, Hottenga, J J, Stehouwer, C D A, Van Der Kallen, C J H, Schalkwijk, C G, Van Den Berg, L H, Van Zwet, E W, Mei, H, Li, Y, Lemire, M, Hudson, T J, Slagboom, P E, Wijmenga, C, Veldink, J H, Van Greevenbroek, M M J, Van Duijn, C M, Boomsma, D I, Jansen, R & the BIOS Consortium 2017, ' Disease variants alter transcription factor levels and methylation of their binding sites ', Nature Genetics, vol. 49, no. 1, pp. 131-138 . https://doi.org/10.1038/ng.3721
Most disease associated genetic risk factors are non-coding, making it challenging to design experiments to understand their functional consequences. Identification of expression quantitative trait loci (eQTLs) has been a powerful approach to infer d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27c98c4c281593baa0199386ee056458
https://cris.maastrichtuniversity.nl/en/publications/2046a4f0-be49-4002-a857-2b4c3dc7aeaa
https://cris.maastrichtuniversity.nl/en/publications/2046a4f0-be49-4002-a857-2b4c3dc7aeaa
Autor:
Leonard H. van den Berg, Dorret I. Boomsma, Rick Jansen, Harm-Jan Westra, Daria V. Zhernakova, Peter A C 't Hoen, Albert Hofman, P. Mila Jhamai, Patrick Deelen, Jan Bot, Cisca Wijmenga, Irene Nooren, Yang I. Li, Szymon M. Kielbasa, Maarten van Iterson, Coen D.A. Stehouwer, Michiel van Galen, Freerk van Dijk, Jan H. Veldink, Marleen M.J. van Greevenbroek, Marian Beekman, Casper G. Schalkwijk, Hailiang Mei, Alexandra Zhernakova, Carla J.H. van der Kallen, Jouke J. Hottenga, Wibowo Arindrarto, Peter van ‘t Hof, René Pool, P. Eline Slagboom, André G. Uitterlinden, Diana van Heemst, Marijn Verkerk, Niek de Klein, Bastiaan T. Heijmans, Aaron Isaacs, Matthijs Moed, Lude Franke, Cornelia M. van Duijn, Ettje F. Tigchelaar, Marc Jan Bonder, Joyce B. J. van Meurs, Joris Deelen, Martijn Vermaat, Jenny van Dongen, Jeroen van Rooij, Morris A. Swertz
Publikováno v:
Nature Genetics, 49(1), 139-145. Nature Publishing Group
Nature Genetics, 49(1), 139-145
Nat Genet
Zhernakova, D V, Deelen, P, Vermaat, M, Van Iterson, M, Van Galen, M, Arindrarto, W, Van't Hof, P, Mei, H, Van Dijk, F, Westra, H J, Bonder, M J, Van Rooij, J, Verkerk, M, Jhamai, P M, Moed, M, Kielbasa, S M, Bot, J, Nooren, I, Pool, R, Van Dongen, J, Hottenga, J J, Stehouwer, C D A, Van Der Kallen, C J H, Schalkwijk, C G, Zhernakova, A, Li, Y, Tigchelaar, E F, De Klein, N, Beekman, M, Deelen, J, Van Heemst, D, Van Den Berg, L H, Hofman, A, Uitterlinden, A G, Van Greevenbroek, M M J, Veldink, J H, Boomsma, D I, Van Duijn, C M, Wijmenga, C, Slagboom, P E, Swertz, M A, Isaacs, A, Van Meurs, J B J, Jansen, R, Heijmans, B T, Hoen't, P A C & Franke, L 2017, ' Identification of context-dependent expression quantitative trait loci in whole blood ', Nature Genetics, vol. 49, no. 1, pp. 139-145 . https://doi.org/10.1038/ng.3737
Nature Genetics
Zhernakova, D V, Deelen, P, Vermaat, M, van Iterson, M, van Galen, M, Arindrarto, W, van 't Hof, P, Mei, H, van Dijk, F, Westra, H-J, Bonder, M J, van Rooij, J, Verkerk, M, Jhamai, P M, Moed, M, Kielbasa, S M, Bot, J, Nooren, I, Pool, R, van Dongen, J, Hottenga, J J, Stehouwer, C D A, van der Kallen, C J H, Schalkwijk, C G, Zhernakova, A, Li, Y, Tigchelaar, E F, de Klein, N, Beekman, M, Deelen, J, van Heemst, D, van den Berg, L H, Hofman, A, Uitterlinden, A G, Van Greevenbroek, M J, Veldink, J H, Boomsma, D I, van Duijn, C M, Wijmenga, C, Slagboom, P E, Swertz, M A, Isaacs, A, van Meurs, J B J, Jansen, R, Heijmans, B T, ’t Hoen, P A C & Franke, L 2017, ' Identification of context-dependent expression quantitative trait loci in whole blood ', Nature Genetics, vol. 49, no. 1, pp. 139-145 . https://doi.org/10.1038/ng.3737
Nature Genetics, 49(1), 139–145. Nature Publishing Group
Nature Genetics, 49(1), 139-145
Nat Genet
Zhernakova, D V, Deelen, P, Vermaat, M, Van Iterson, M, Van Galen, M, Arindrarto, W, Van't Hof, P, Mei, H, Van Dijk, F, Westra, H J, Bonder, M J, Van Rooij, J, Verkerk, M, Jhamai, P M, Moed, M, Kielbasa, S M, Bot, J, Nooren, I, Pool, R, Van Dongen, J, Hottenga, J J, Stehouwer, C D A, Van Der Kallen, C J H, Schalkwijk, C G, Zhernakova, A, Li, Y, Tigchelaar, E F, De Klein, N, Beekman, M, Deelen, J, Van Heemst, D, Van Den Berg, L H, Hofman, A, Uitterlinden, A G, Van Greevenbroek, M M J, Veldink, J H, Boomsma, D I, Van Duijn, C M, Wijmenga, C, Slagboom, P E, Swertz, M A, Isaacs, A, Van Meurs, J B J, Jansen, R, Heijmans, B T, Hoen't, P A C & Franke, L 2017, ' Identification of context-dependent expression quantitative trait loci in whole blood ', Nature Genetics, vol. 49, no. 1, pp. 139-145 . https://doi.org/10.1038/ng.3737
Nature Genetics
Zhernakova, D V, Deelen, P, Vermaat, M, van Iterson, M, van Galen, M, Arindrarto, W, van 't Hof, P, Mei, H, van Dijk, F, Westra, H-J, Bonder, M J, van Rooij, J, Verkerk, M, Jhamai, P M, Moed, M, Kielbasa, S M, Bot, J, Nooren, I, Pool, R, van Dongen, J, Hottenga, J J, Stehouwer, C D A, van der Kallen, C J H, Schalkwijk, C G, Zhernakova, A, Li, Y, Tigchelaar, E F, de Klein, N, Beekman, M, Deelen, J, van Heemst, D, van den Berg, L H, Hofman, A, Uitterlinden, A G, Van Greevenbroek, M J, Veldink, J H, Boomsma, D I, van Duijn, C M, Wijmenga, C, Slagboom, P E, Swertz, M A, Isaacs, A, van Meurs, J B J, Jansen, R, Heijmans, B T, ’t Hoen, P A C & Franke, L 2017, ' Identification of context-dependent expression quantitative trait loci in whole blood ', Nature Genetics, vol. 49, no. 1, pp. 139-145 . https://doi.org/10.1038/ng.3737
Nature Genetics, 49(1), 139–145. Nature Publishing Group
Genetic risk factors often localize to noncoding regions of the genome with unknown effects on disease etiology. Expression quantitative trait loci (eQTLs) help to explain the regulatory mechanisms underlying these genetic associations. Knowledge of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d14ea91e09dcb763b268797cbc8598e2
https://cris.maastrichtuniversity.nl/en/publications/0283fe2f-d7a9-489d-aaa9-5785787dc5e4
https://cris.maastrichtuniversity.nl/en/publications/0283fe2f-d7a9-489d-aaa9-5785787dc5e4
Autor:
Joyce Van Meurs, Marc Jan Bonder, Marleen Van Greevenbroek, Michel Nivard, Morris Swertz, René Pool, H. Eka D. Suchiman, Coen Stehouwer, Marijn Verkerk, Cornelia Van Duijn, Jenny Van Dongen, Pieternella Slagboom, Marian Beekman, Casper G Schalkwijk, Szymon Kiełbasa, Lude Franke, Rick Jansen, Gonneke Willemsen, Carla Van der Kallen, Patrick Deelen
Publikováno v:
Nature Communications
Nature Communications, 7:11115. Nature Publishing Group
Nature Communications, 7. Nature Publishing Group
van Dongen, J, Nivard, M G, Willemsen, G, Hottenga, J-J, Helmer, Q, Dolan, C V, Ehli, E A, Davies, G E, van Iterson, M, Breeze, C E, Beck, S, Suchiman, H E, Jansen, R, van Meurs, J B, Heijmans, B T, Slagboom, P E & Boomsma, D I 2016, ' Genetic and environmental influences interact with age and sex in shaping the human methylome ', Nature Communications, vol. 7 . https://doi.org/10.1038/ncomms11115
Nature Communications, 7(11115):11115, 1-13. Nature Publishing Group
Nature Communications, 7
van Dongen, J, Nivard, M G, Willemsen, G, Hottenga, J J, Helmer, Q, Dolan, C V, Ehli, E A, Davies, G E, van Iterson, M, Breeze, C E, Beck, S, Pool, R, Suchiman, H E D, Jansen, R, van Meurs, J B, Heijmans, B T, Slagboom, P E & Boomsma, D I 2016, ' Genetic and environmental influences interact with age and sex in shaping the human methylome ', Nature Communications, vol. 7, no. 11115, 11115, pp. 1-13 . https://doi.org/10.1038/ncomms11115
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Nature Communications, 7:11115. Nature Publishing Group
Nature Communications, 7. Nature Publishing Group
van Dongen, J, Nivard, M G, Willemsen, G, Hottenga, J-J, Helmer, Q, Dolan, C V, Ehli, E A, Davies, G E, van Iterson, M, Breeze, C E, Beck, S, Suchiman, H E, Jansen, R, van Meurs, J B, Heijmans, B T, Slagboom, P E & Boomsma, D I 2016, ' Genetic and environmental influences interact with age and sex in shaping the human methylome ', Nature Communications, vol. 7 . https://doi.org/10.1038/ncomms11115
Nature Communications, 7(11115):11115, 1-13. Nature Publishing Group
Nature Communications, 7
van Dongen, J, Nivard, M G, Willemsen, G, Hottenga, J J, Helmer, Q, Dolan, C V, Ehli, E A, Davies, G E, van Iterson, M, Breeze, C E, Beck, S, Pool, R, Suchiman, H E D, Jansen, R, van Meurs, J B, Heijmans, B T, Slagboom, P E & Boomsma, D I 2016, ' Genetic and environmental influences interact with age and sex in shaping the human methylome ', Nature Communications, vol. 7, no. 11115, 11115, pp. 1-13 . https://doi.org/10.1038/ncomms11115
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
The methylome is subject to genetic and environmental effects. Their impact may depend on sex and age, resulting in sex- and age-related physiological variation and disease susceptibility. Here we estimate the total heritability of DNA methylation le