Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Marijke Pellens"'
Autor:
Sara Vandenwijngaert, Peter Pokreisz, Hadewich Hermans, Hilde Gillijns, Marijke Pellens, Noortje A M Bax, Giulia Coppiello, Wouter Oosterlinck, Agnes Balogh, Zoltan Papp, Carlijn V C Bouten, Jozef Bartunek, Jan D'hooge, Aernout Luttun, Erik Verbeken, Marie Christine Herregods, Paul Herijgers, Kenneth D Bloch, Stefan Janssens
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e58841 (2013)
BackgroundThe intracellular second messenger cGMP protects the heart under pathological conditions. We examined expression of phosphodiesterase 5 (PDE5), an enzyme that hydrolyzes cGMP, in human and mouse hearts subjected to sustained left ventricula
Externí odkaz:
https://doaj.org/article/9e817f3d05204959aef0b9fb7fe1b3fc
Autor:
Nele Kindt, Geert Reyns, Olivier Defert, Patrick Schöffski, Massimiliano Mazzone, Agnieszka Wozniak, Carla Riera-Domingo, Marjan Diricx, Marijke Pellens, Tom Janssens, Marzia De Petrini, Natalie De Geest, Peter Pokreisz, Britt Van Renterghem, Lawrence Van Helleputte, Andrea Casazza
Clinical use of doxorubicin (Dox) is limited by cumulative myelo- and cardiotoxicity. This research focuses on the detailed characterization of PhAc-ALGP-Dox, a targeted tetrapeptide prodrug with a unique dual-step activation mechanism, designed to c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8914754f35dc5e01e0cb964ae25c0fda
https://doi.org/10.1158/1535-7163.c.6543549
https://doi.org/10.1158/1535-7163.c.6543549
Autor:
Andrea Casazza, Lawrence Van Helleputte, Britt Van Renterghem, Peter Pokreisz, Natalie De Geest, Marzia De Petrini, Tom Janssens, Marijke Pellens, Marjan Diricx, Carla Riera-Domingo, Agnieszka Wozniak, Massimiliano Mazzone, Patrick Schöffski, Olivier Defert, Geert Reyns, Nele Kindt
Publikováno v:
Molecular cancer therapeutics. 21(4)
Clinical use of doxorubicin (Dox) is limited by cumulative myelo- and cardiotoxicity. This research focuses on the detailed characterization of PhAc-ALGP-Dox, a targeted tetrapeptide prodrug with a unique dual-step activation mechanism, designed to c
Autor:
Marinee Chuah, Stefan Janssens, Christophe Dubois, Lertlak Chaothawee, Jan Bogaert, Desire Collen, Piet Claus, Hilde Gillijns, Witold Streb, Peter Pokreisz, Sara Vandenwijngaert, Olivier Gheysens, Ann Belmans, Frans Van de Werf, Zeger Debyser, Glenn Marsboom, Hélène Dépelteau, Frederik Maes, Erik Verbeken, Thierry VandenDriessche, Xiaoshun Liu, Marijke Pellens
Publikováno v:
Journal of the American College of Cardiology
Journal of the American College of Cardiology; Vol 55
Journal of the American College of Cardiology; Vol 55
OBJECTIVES: We compared biological repair after acute myocardial infarction (AMI) with selected porcine progenitor cell populations. BACKGROUND: Cell types and mechanisms responsible for myocardial repair after AMI remain uncertain. METHODS: In a bli
Autor:
Pieter Vermeersch, Peter Brouckaert, Glenn Marsboom, Stefan Janssens, Peter Pokreisz, Patrick Sips, Emmanuel S. Buys, Hilde Gillijns, Kenneth D. Bloch, Mieke Dewerchin, Marijke Pellens
Publikováno v:
The Open Cardiovascular Medicine Journal
Objective: Soluble guanylate cyclase (sGC), a heterodimer composed of α and β subunits, synthesizes cGMP in response to nitric oxide (NO). NO modulates vascular tone and structure but the relative contributions of cGMP-dependent versus cGMP-indepen
Autor:
Stefan Janssens, Xiaoshun Liu, Alfons Van Lommel, An Van Den Bergh, Paul Herijgers, Emmanuel S. Buys, Liesbeth Biesmans, Luc Schoonjans, Hilde Gillijns, Karin R. Sipido, Johan Vanhaecke, Sara Vandenwijngaert, Marijke Pellens, Virginie Bito, Cornelius J. Busch, Olivier Gheysens, Pieter Vermeersch, Erik Verbeken, Peter Pokreisz, Kenneth D. Bloch, Glenn Marsboom, Ilse Lenaerts
Publikováno v:
Circulation. 119:408-416
Background— Ventricular expression of phosphodiesterase-5 (PDE5), an enzyme responsible for cGMP catabolism, is increased in human right ventricular hypertrophy, but its role in left ventricular (LV) failure remains incompletely understood. We ther
Autor:
Hilde Gillijns, Xiaoshun Liu, Desire Collen, Olivier Gheysens, Glenn Marsboom, Peter Pokreisz, Stefan Janssens, Pieter Vermeersch, Marijke Pellens
Publikováno v:
Stem Cells. 26:1017-1026
Circulating endothelial progenitor cells (EPCs) contribute to neovascularization of ischemic tissues and repair of injured endothelium. The role of bone marrow-derived progenitor cells in hypoxia-induced pulmonary vascular remodeling and their tissue
Autor:
Hilde Gillijns, Rudi Busse, Friedrich Grimminger, Eduardo Barbosa-Sicard, Ingrid Fleming, In Hae Kim, Beate Fisslthaler, Marijke Pellens, Desire Collen, Zsolt Szelid, Bruce D. Hammock, Anton Jan van Zonneveld, Peter Pokreisz, Stefan Janssens, Pieter Vermeersch, John R. Falck, Ladislau Kiss
Publikováno v:
Hypertension. 47:762-770
We assessed pulmonary cytochrome P450 (CYP) epoxygenase expression and activity during hypoxia and explored the effects of modulating epoxygenase activity on pulmonary hypertension. The acute hypoxic vasoconstrictor response was studied in Swiss Webs
Autor:
Stefan Janssens, Pieter Vermeersch, Zsolt Szelid, Peter Jans, Marielle Scherrer-Crosbie, Desire Collen, Luc Schoonjans, Frans Van de Werf, Kenneth D. Bloch, Peter Pokreisz, Michael H. Picard, Marijke Pellens, Marc Tjwa, Hilde Gillijns
Publikováno v:
Circulation Research. 94:1256-1262
Nitric oxide (NO) is an important modulator of cardiac performance and left ventricular (LV) remodeling after myocardial infarction (MI). We tested the effect of cardiomyocyte-restricted overexpression of one NO synthase isoform, NOS3, on LV remodeli
Autor:
Karin R. Sipido, Kenneth D. Bloch, Marijke Pellens, Pieter Vermeersch, Alfons Van Lommel, Cornelius J. Busch, Erik Verbeken, Peter Pokreisz, Paul Herijgers, Luc Schoonjans, Emmanuel S. Buys, Xiaoshun Liu, Olivier Gheysens, Johan Vanhaecke, Hilde Gillijns, Stefan Janssens, Virginie Bito, An Van Den Bergh, Liesbeth Biesmans, Ilse Lenaerts, Glenn Marsboom, Sara Vandenwijngaert
Publikováno v:
Circulation. 120
We appreciate the comments by Cingolani et al on a possible involvement of Na+/H+ exchanger (NHE-1) in signaling mechanisms downstream of cGMP that can mediate cardioprotection after myocardial infarction. These authors previously reported that NHE-1