Secretion of pro‐angiogenic extracellular vesicles during hypoxia is dependent on the autophagy‐related protein GABARAPL1

Autor: Tom G. Keulers, Sten F. Libregts, Joel E.J. Beaumont, Kim G. Savelkouls, Johan Bussink, Hans Duimel, Ludwig Dubois, Marijke I. Zonneveld, Carmen López‐Iglesias, Karel Bezstarosti, Jeroen A. Demmers, Marc Vooijs, Marca Wauben, Kasper M.A. Rouschop

Publikováno v: Journal of Extracellular Vesicles, Vol 10, Iss 14, Pp n/a-n/a (2021)

Abstract Tumour hypoxia is a hallmark of solid tumours and contributes to tumour progression, metastasis development and therapy resistance. In response to hypoxia, tumour cells secrete pro‐angiogenic factors to induce blood vessel formation and re

Externí odkaz: https://doaj.org/article/af6b9ede953b475aa1ad89c65bcf4ab4

Pathogen recognition by NK cells amplifies the pro-inflammatory cytokine production of monocyte-derived DC via IFN-γ

Autor: Tammy Oth, Thomas H. P. M. Habets, Wilfred T. V. Germeraad, Marijke I. Zonneveld, Gerard M. J. Bos, Joris Vanderlocht

Publikováno v: BMC Immunology, Vol 19, Iss 1, Pp 1-13 (2018)

Abstract Background Besides their prominent role in the elimination of infected or malignantly transformed cells, natural killer (NK) cells serve as modulators of adaptive immune responses. Enhancing bidirectional crosstalk between NK cells and dendr

Externí odkaz: https://doaj.org/article/0626c82c7482453e9eb0f80a81265a07

ATG12 deficiency results in intracellular glutamine depletion, abrogation of tumor hypoxia and a favorable prognosis in cancer

Autor: Tom G. Keulers, Alexander Koch, Marike W. van Gisbergen, Lydie M.O. Barbeau, Marijke I. Zonneveld, Monique C. de Jong, Kim G.M. Savelkouls, Roel G. Wanders, Johan Bussink, Veerle Melotte, Kasper M.A. Rouschop

Publikováno v: Autophagy, 18(8), 1898-1914. Landes Bioscience
Autophagy, 18, 1898-1914
Autophagy, 18, 8, pp. 1898-1914

Contains fulltext : 283427.pdf (Publisher’s version ) (Open Access) Hypoxia is a common feature of solid tumors and is associated with increased tumor progression, resistance to therapy and increased metastasis. Hence, tumor hypoxia is a prognostic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62b319fd62a6cb893f196190d43f25a6
https://hdl.handle.net/2066/283427

EGFRvIII expression triggers a metabolic dependency and therapeutic vulnerability sensitive to autophagy inhibition

Autor: Resi M. E. Colaris, Kim G.M. Savelkouls, Johan Bussink, Marijke I. Zonneveld, Kasper M.A. Rouschop, Barry Jutten, Onno P.M. Teernstra, Julio Sotelo, Hanneke J.M. Peeters, Ruud Clarijs, Marc Vooijs, Linda Ackermans, Guido Lammering, Inge Compter, Olaf E. M. G. Schijns, Marco B.E. Schaaf, Ludwig Dubois, Jan Theys, Tom G. Keulers

Publikováno v: Autophagy
Autophagy, 14, 2, pp. 283-295
Autophagy, 14, 283-295
Autophagy, 14(2), 283-295. Landes Bioscience

Expression of EGFRvIII is frequently observed in glioblastoma and is associated with increased cellular proliferation, enhanced tolerance to metabolic stresses, accelerated tumor growth, therapy resistance and poor prognosis. We observed that express

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2ee8e3648ec475fbc06ae4baf28a0d2
https://doi.org/10.1080/15548627.2017.1409926

EV-TRACK: transparent reporting and centralizing knowledge in extracellular vesicle research

Autor: Eva De Smedt, Bieke Soen, Marta Monguió-Tortajada, Jasper Anckaert, Erminia Romano, Els Beghein, Hina Kalra, Alessandra Lo Cicero, Michael W. Pfaffl, Laurence Bertier, Bert Dhondt, Edward Geeurickx, Özden Akay, Lorraine O'Driscoll, Frederik J. Verweij, Alan Van Goethem, Dominik Buschmann, Olivier De Wever, Zoraida Andreu Martinez, Susanne G. van der Grein, Carina Leonelli, Vincent Hyenne, Shu Liu, Prabhu Mathiyalagan, Guillaume van Niel, Andrew D Foers, Niels Vandamme, Joeri Tulkens, Petra Leidinger, Jan Van Deun, James Brian Byrd, Suzanne Vanhauwaert, David Kim, Patrizia Agostinis, Seyma Demirsoy, Esther N. M. Nolte-‘t Hoen, Stephanie Boukouris, Aleksandra M. Dudek, Michel Bremer, Anna Cmoch, Sandra Kraemer, Kathrin Gärtner, Clotilde Théry, Hetty Helsmoortel, Farzaneh Ghazavi, Pieter Mestdagh, Dillon C. Muth, Jo Vandesompele, Grace V. Hancock, Lien Lippens, Tom Groot Kormelink, Tom A. P. Driedonks, Abdou ElSharawy, Sushma Anand, Marijke I. Zonneveld, Benjamin J. Scicluna, Joanna Kowal, Susmita Sahoo, Lesley Cheng, Safia Thaminy, Isabel Van Audenhove, Suresh Mathivanan, Ilaria Floris, Glenn Vergauwen, Geert Berx, Jan Gettemans, Johannes V. Swinnen, Yaxuan Liang, Victoria Depoorter, Shaun Martin, Alexander R. van Vliet, Natalia G. Sampaio, Martijn J. C. van Herwijnen, Bernd Giebel, Abhishek D. Garg, Bjarke Primdal-Bengtson, An Hendrix, Gloria Milani, Tamás Matusek, Liselot Mus, Annelynn Wallaert, Andrew F. Hill, Roberta Palmulli, Maarit Takatalo, Tine Baetens, Clara Casert, Janneke Boere, Monisha Samuel, Marca H. M. Wauben, Nadine Van Roy, Delphine Daveloose, Anneleen Steels, Andrea Németh, Kenneth W. Witwer, Quentin Rousseau

Publikováno v: Nature Methods
Nature Methods, Nature Publishing Group, 2017, 14 (3), pp.228-232
Nature Methods, 2017, 14 (3), pp.228-232
ResearcherID
Nature methods 14(3), 228-232 (2017). doi:10.1038/nmeth.4185
Nature Methods, 14(3), 228. Nature Publishing Group
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname

We argue that the field of extracellular vesicle (EV) biology needs more transparent reporting to facilitate interpretation and replication of experiments. To achieve this, we describe EV-TRACK, a crowdsourcing knowledgebase (http://evtrack.org) that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b28302581cb9abae3468baf7bf176b8
https://hal.archives-ouvertes.fr/hal-01607037