Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Marijke De Bock"'
Autor:
Magdalena Kurtyka, Frank Wessely, Sarah Bau, Eseoghene Ifie, Liqun He, Nienke M. de Wit, Alberte Bay Villekjær Pedersen, Maximilian Keller, Caleb Webber, Helga E. de Vries, Olaf Ansorge, Christer Betsholtz, Marijke De Bock, Catarina Chaves, Birger Brodin, Morten S. Nielsen, Winfried Neuhaus, Robert D. Bell, Tamás Letoha, Axel H. Meyer, Germán Leparc, Martin Lenter, Dominique Lesuisse, Zameel M. Cader, Stephen T. Buckley, Irena Loryan, Claus U. Pietrzik
Publikováno v:
European Journal of Cell Biology, Vol 103, Iss 2, Pp 151406- (2024)
Despite extensive research, targeted delivery of substances to the brain still poses a great challenge due to the selectivity of the blood-brain barrier (BBB). Most molecules require either carrier- or receptor-mediated transport systems to reach the
Externí odkaz:
https://doaj.org/article/24cf1f3bfe6c41b79a62e5eaa26fce38
Autor:
Marijke De Bock, Maarten De Smet, Stijn Verwaerde, Hanane Tahiri, Steffi Schumacher, Valérie Van Haver, Katja Witschas, Christian Steinhäuser, Nathalie Rouach, Roosmarijn E. Vandenbroucke, Luc Leybaert
Publikováno v:
JCI Insight, Vol 7, Iss 16 (2022)
The blood-brain barrier is formed by capillary endothelial cells expressing connexin 37 (Cx37), Cx40, and Cx43 and is joined by closely apposed astrocytes expressing Cx43 and Cx30. We investigated whether connexin-targeting peptides could limit barri
Externí odkaz:
https://doaj.org/article/066b30bb320c47808fa69a498209687e
Publikováno v:
Mediators of Inflammation, Vol 2015 (2015)
The coordination of tissue function is mediated by gap junctions (GJs) that enable direct cell-cell transfer of metabolic and electric signals. GJs are formed by connexin (Cx) proteins of which Cx43 is most widespread in the human body. Beyond its ro
Externí odkaz:
https://doaj.org/article/127c0e9c2698499c88274ee151561529
Autor:
Paul D. Lampe, Christian C. Naus, John F. Bechberger, Luc Leybaert, Marijke De Bock, Nan Wang, Moises Freitas-Andrade
Publikováno v:
The Journal of Experimental Medicine
JOURNAL OF EXPERIMENTAL MEDICINE
JOURNAL OF EXPERIMENTAL MEDICINE
This study demonstrates that astrocytic connexin43 gap junction hemichannels are largely controlled by four C-terminal tail–located serine residues and provides mechanistic insight on how phosphorylation of these residues affects recovery from stro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7e6e741ac41ac945fce5305a855351b
http://europepmc.org/articles/PMC6446879
http://europepmc.org/articles/PMC6446879
Autor:
Christian Vanhove, Valérie Van Haver, Benedicte Descamps, Luc Leybaert, Geert Bultynck, Dmitri V. Krysko, Maarten De Smet, Tinneke Delvaeye, Delphine Hoorelbeke, Elke Decrock, Marijke De Bock
Publikováno v:
CELL DEATH & DISEASE
Cell Death and Disease, Vol 11, Iss 3, Pp 1-17 (2020)
Cell Death and Disease, Vol 11, Iss 3, Pp 1-17 (2020)
Radiotherapeutic treatment consists of targeted application of radiation beams to a tumor but exposure of surrounding healthy tissue is inevitable. In the brain, ionizing radiation induces breakdown of the blood–brain barrier by effects on brain mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8f9afa99565196c6ec7a521e3db8644
https://doi.org/10.1038/s41419-020-2392-5
https://doi.org/10.1038/s41419-020-2392-5
Publikováno v:
Neurochemical Research. 42:2519-2536
Neuronal survival, electrical signaling and synaptic activity require a well-balanced micro-environment in the central nervous system. This is achieved by the blood-brain barrier (BBB), an endothelial barrier situated in the brain capillaries, that c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ad0d864701e7bf4dc71078bd3c5cd38
https://doi.org/10.1007/s11064-017-2313-x
https://doi.org/10.1007/s11064-017-2313-x
Autor:
Marijke De Bock, Mathieu Vinken, Elke Decrock, Nan Wang, Tinneke Delvaeye, Raghda Ramadan, Delphine Hoorelbeke, An Aerts, Luc Leybaert, Geert Bultynck, Dmitri V. Krysko, Sarah Baatout
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1864:1099-1120
Although radiotherapy is commonly used to treat cancer, its beneficial outcome is frequently hampered by the radiation resistance of tumor cells and adverse reactions in normal tissues. Mechanisms of cell-to-cell communication and how intercellular s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7c57818955dfa774afe245be7b6b7e5
https://doi.org/10.1016/j.bbamcr.2017.02.007
https://doi.org/10.1016/j.bbamcr.2017.02.007
Autor:
Astrid Bottelbergs, Bart Hermans, Nikolay V. Manyakov, Cindy Wintmolders, M. Borgers, Gethin Davies, Detlef Balschun, Marijke De Bock, Wilhelmus Drinkenburg, Bianca Van Broeck, Clara Theunis, Sofia Jacob
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-19 (2019)
Scientific Reports, 9:16363. Nature Publishing Group
Scientific Reports, Vol 9, Iss 1, Pp 1-19 (2019)
Scientific Reports, 9:16363. Nature Publishing Group
Multiple animal models have been created to gain insight into Alzheimer’s disease (AD) pathology. Among the most commonly used models are transgenic mice overexpressing human amyloid precursor protein (APP) with mutations linked to familial AD, res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adbc34970396621e1168f1c6bb84d3ad
http://europepmc.org/articles/PMC6841667
http://europepmc.org/articles/PMC6841667
Autor:
Delphine, Hoorelbeke, Elke, Decrock, Maarten, De Smet, Marijke, De Bock, Benedicte, Descamps, Valérie, Van Haver, Tinneke, Delvaeye, Dmitri V, Krysko, Christian, Vanhove, Geert, Bultynck, Luc, Leybaert
Publikováno v:
Cell Death & Disease
Radiotherapeutic treatment consists of targeted application of radiation beams to a tumor but exposure of surrounding healthy tissue is inevitable. In the brain, ionizing radiation induces breakdown of the blood–brain barrier by effects on brain mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1ea54bc412b92ce8b61ae7bae57d4f7f
https://pubmed.ncbi.nlm.nih.gov/32188841
https://pubmed.ncbi.nlm.nih.gov/32188841
Autor:
Bert Vanheel, Geert Bultynck, Elke Decrock, Benjamin Wacquier, Geneviève Dupont, Kelly Decaluwé, Johan Van de Voorde, Mélissa Bol, Luc Leybaert, Nan Wang, Marijke De Bock, Ashish A. Gadicherla, Harold V.M. van Rijen, Dmitri V. Krysko
Publikováno v:
Cardiovascular Research. 113:195-206
Aims Connexins form gap-junctions (GJs) that directly connect cells, thereby coordinating vascular cell function and controlling vessel diameter and blood flow. GJs are composed of two hemichannels contributed by each of the connecting cells. Hemicha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4569e7d8c74e60e7735df5677fa02df4
https://doi.org/10.1093/cvr/cvw215
https://doi.org/10.1093/cvr/cvw215